Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma

Abstract

Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells

“…Accumulating evidence has strongly suggested that β-catenin is a crucial factor in various processes of cancer development [31-35]. In our study, we found that β-catenin expression was associated with regional lymph node involvement but not the overall survival.…”

Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India

“…The western blot revealed an overall up‐regulation of b‐catenin in 69% only. The clinical correlation is described elsewhere, but noteworthy was that all the postadolescent cases revealed absent expression, whereas those JNAs showing facial disfiguration revealed enhanced expression of beta‐catenin.…”

“…A comparison of the two extremes of molecular expressions (of a particular marker) can likely characterize a specific clinical phenotype associated with enhanced (or under‐) expression. For example, clinical phenotypes of beta‐catenin expression have already been mentioned . Similarly, the higher FGF expression has been seen in postadolescents and associated with enhanced intraoperative bleeding, recurrence, and smaller tumor size.…”

“…For example, the AR expression has not shown a significant enhancement in the current era (as compared to the past), and neither is our population restricted to pure adolescent age group these days. The enhancement of Ras may contribute to a changing aggression of JNA these days, whereas specific clinical phenotypes associated with beta‐catenin may also be applicable in global context.…”

Biomolecular Analysis of Juvenile Nasopharyngeal Angiofibroma

“…Expression of GSTM1 mRNA (which encodes glutathione S-transferase M1, a protein involved in detoxification) should be normally in all human beings. When this is not expressed there is an increased risk of developing some malignancies [17,42]. Two studies performed on GSTM1-null genotype [17,33].…”