Current status and challenges in the application of microbial PHA particles

Liu, Jiaxuan; Zhou, Ziqi; Li, Haoru; Yang, Xinyu; Wang, Zeyu; Xiao, Jian; Wei, Dai-Xu

doi:10.1016/j.partic.2023.08.011

Cited by 6 publications

(3 citation statements)

References 107 publications

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“…[ 1 , 17 ]. All of these suggest that a platform to produce native-like collagen from cell-derived matrix was provided and hCol could be potentially used as in vitro cell culture model in tissue engineering or cosmetics [ 66 ]. In the future, the mechanism of how collagen structure promotes cell phenotype and skin repair needs to be investigated in combination with more molecular biology tests.…”

Section: Discussionmentioning

confidence: 99%

Human extracellular matrix (ECM)-like collagen and its bioactivity

Zhou,

Li,

Pan

et al. 2024

Regenerative Biomaterials

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Collagen, the most abundant structural protein in the human extracellular matrix (ECM), provides essential support for tissues and guides tissue development. Despite its widespread use in tissue engineering, there remains uncertainty regarding the optimal selection of collagen sources. Animal-derived sources pose challenges such as immunogenicity, while the recombinant system is hindered by diminished bioactivity. In this study, we hypothesized that human ECM-like collagen (hCol) could offer an alternative for tissue engineering. In this study, a facile platform was provided for generating hCol derived from mesenchymal stem cells (MSCs) with a hierarchical structure and biochemical properties resembling native collagen. Our results further demonstrated that hCol could facilitate basal biological behaviors of human adipose-derived stem cells (hASCs), including viability, proliferation, migration and adipocyte-like phenotype. Additionally, it could promote cutaneous wound closure. Due its high similarity to native collagen and good bioactivity, hCol holds promise as a prospective candidate for in vitro and in vivo applications in tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Human extracellular matrix (ECM)-like collagen and its bioactivity

Zhou,

Li,

Pan

et al. 2024

Regenerative Biomaterials

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“…PHA materials are extensively utilized in the medical industry owing to their excellent biodegradability and biocompatibility. PHA particles exhibit non-toxicity and are devoid of any pyrogenic, allergenic, carcinogenic, inflammatory, or teratogenic properties [124]. The employment of PHA beads has proven to be useful for medical and industrial applications such as protein purification [125], diagnostics and imaging [126,127], tissue engineering, etc.…”

Section: Applications Of Polyhydroxyalcanoatesmentioning

confidence: 99%

“…The newly combined PHB-liposome particles demonstrated no toxicity to HEK (human embryonic kidney) and HaCaT (human immortalized keratinocyte) cells [131]. These PHB nanoparticles (NPs) exhibit potential as active carriers for both hydrophobic and hydrophilic active ingredients, including antioxidants, anti-aging compounds, complex natural extracts, and antibacterial agents [124]. PHA particles offer versatility in modifications through various surface-binding proteins, thereby expanding their practical applications and reducing PHA nanoparticle cytotoxicity [132].…”

Section: Applications Of Polyhydroxyalcanoatesmentioning

confidence: 99%

Embracing Sustainability: The World of Bio-Based Polymers in a Mini Review

Righetti,

Faedi,

Famulari

2024

Polymers

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The proliferation of polymer science and technology in recent decades has been remarkable, with synthetic polymers derived predominantly from petroleum-based sources dominating the market. However, concerns about their environmental impacts and the finite nature of fossil resources have sparked interest in sustainable alternatives. Bio-based polymers, derived from renewable sources such as plants and microbes, offer promise in addressing these challenges. This review provides an overview of bio-based polymers, discussing their production methods, properties, and potential applications. Specifically, it explores prominent examples including polylactic acid (PLA), polyhydroxyalkanoates (PHAs), and polyhydroxy polyamides (PHPAs). Despite their current limited market share, the growing awareness of environmental issues and advancements in technology are driving increased demand for bio-based polymers, positioning them as essential components in the transition towards a more sustainable future.

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Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

Li,

Zhou,

Zhou

et al. 2024

Journal of Polymer Science

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In recent years, the prevalence of bone diseases is showing an increasing trend, which is mainly attributed to the aging of the global population. However, bone repair and regeneration are still an unsolved problem in the treatment of bone diseases, which include a series of biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) are spherical particles composed of photocrosslinked natural hydrogel components. Due to their morphology, injectability, and biocompatibility, PNHMs are widely used in tissue regeneration, particularly for bone defects. In this article, we review the available photocrosslinked natural materials for PNHMs, and then introduce their preparation methods. After that, we summarize the important advanced functionalities of PNHMs. For example, PNHMs can be loaded with different active ingredients to exert anti‐inflammatory, antibacterial, and antioxidant effects, while also realizing lubrication due to their specific shape and size distribution. In addition, the function of capturing ions can be realized via coordination. When applied in bone tissue engineering, PNHMs can promote angiogenesis and osteogenesis, with great potential in the treatment of bone diseases. Finally, the challenges and prospects of PNHMs for bone repair are discussed.

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Current status and challenges in the application of microbial PHA particles

Cited by 6 publications

References 107 publications

Human extracellular matrix (ECM)-like collagen and its bioactivity

Human extracellular matrix (ECM)-like collagen and its bioactivity

Embracing Sustainability: The World of Bio-Based Polymers in a Mini Review

Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

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