Current state of the art of regional hyperthermia treatment planning: a review

Kok, H. Petra; Wust, Peter; Stauffer, Paul R.; Bardati, F.; Rhoon, Gerard C. van; Crezee, J.

doi:10.1186/s13014-015-0503-8

Cited by 138 publications

(113 citation statements)

References 110 publications

(131 reference statements)

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“…Thus, heating methods that allow for local adjustment of the temperature distribution are preferred, such as radiative heating using a phased array of multiple antennas [70]. Radiative heating also allows for HT treatment planning [71][72][73][74], which may yield better temperature distributions and the possibility to avoid hot spots. With temperature being heterogeneous and not constant in time, reporting is preferably done using a set of thermal dose parameters [69].…”

Section: Thermal Dosimetrymentioning

confidence: 99%

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

Horst

Versteijne

Besselink

et al. 2017

International Journal of Hyperthermia

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Objective: In pancreatic cancer, which is therapy resistant due to its hypoxic microenvironment, hyperthermia may enhance the effect of radio(chemo)therapy. The aim of this systematic review is to investigate the validity of the hypothesis that hyperthermia added to radiotherapy and/or chemotherapy improves treatment outcome for pancreatic cancer patients. Methods and materials: We searched MEDLINE and Embase, supplemented by handsearching, for clinical studies involving hyperthermia in pancreatic cancer patients. The quality of studies was evaluated using the Oxford Centre for Evidence-Based Medicine levels of evidence. Primary outcome was treatment efficacy; we calculated overall response rate and the weighted estimate of the population median overall survival (m p ) and compared these between hyperthermia and control cohorts. Results: Overall, 14 studies were included, with 395 patients with locally advanced and/or metastatic pancreatic cancer of whom 248 received hyperthermia. Patients were treated with regional (n ¼ 189), intraoperative (n ¼ 39) or whole-body hyperthermia (n ¼ 20), combined with chemotherapy, radiotherapy or both. Quality of the studies was low, with level of evidence 3 (five studies) and 4. The six studies including a control group showed a longer m p in the hyperthermia groups than in the control groups (11.7 vs. 5.6 months). Overall response rate, reported in three studies with a control group, was also better for the hyperthermia groups (43.9% vs. 35.3%). Conclusions: Hyperthermia, when added to chemotherapy and/or radiotherapy, may positively affect treatment outcome for patients with pancreatic cancer. However, the quality of the reviewed studies was limited and future randomised controlled trials are needed to establish efficacy. ARTICLE HISTORY

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Section: Thermal Dosimetrymentioning

confidence: 99%

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

Horst

Versteijne

Besselink

et al. 2017

International Journal of Hyperthermia

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“…Treatment planning is essential to optimise the radiation dose and temperature delivered to the tumour while minimising the risk of normal tissue complications. Currently, treatment planning for these two modalities is always performed separately, without taking the synergistic action between the two modalities into account [3][4][5][6]. Because of the synergy, treatment outcome strongly depends on the radiosensitising effect of the temperature distribution on the radiotherapy dose distribution.…”

Section: Introductionmentioning

confidence: 99%

Thermoradiotherapy planning: Integration in routine clinical practice

Crezee

Leeuwen

Oei

et al. 2015

International Journal of Hyperthermia

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Planning of combined radiotherapy and hyperthermia treatments should be performed taking the synergistic action between the two modalities into account. This work evaluates the available experimental data on cytotoxicity of combined radiotherapy and hyperthermia treatment and the requirements for integration of hyperthermia and radiotherapy treatment planning into a single planning platform. The underlying synergistic mechanisms of hyperthermia include inhibiting DNA repair, selective killing of radioresistant hypoxic tumour tissue and increased radiosensitivity by enhanced tissue perfusion. Each of these mechanisms displays different dose-effect relations, different optimal time intervals and different optimal sequences between radiotherapy and hyperthermia. Radiosensitisation can be modelled using the linear-quadratic (LQ) model to account for DNA repair inhibition by hyperthermia. In a recent study, an LQ model-based thermoradiotherapy planning (TRTP) system was used to demonstrate that dose escalation by hyperthermia is equivalent to $10 Gy for prostate cancer patients treated with radiotherapy. The first step for more reliable TRTP is further expansion of the data set of LQ parameters for normally oxygenated normal and tumour tissue valid over the temperature range used clinically and for the relevant time intervals between radiotherapy and hyperthermia. The next step is to model the effect of hyperthermia in hypoxic tumour cells including the physiological response to hyperthermia and the resulting reoxygenation. Thermoradiotherapy planning is feasible and a necessity for an optimal clinical application of hyperthermia combined with radiotherapy in individual patients.

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“…Recently, there were many reviews about hyperthermia randomized trials and indicated that it can enhance the efficacy of both radiotherapy and chemotherapy, and also many non-and randomized clinical trials have demonstrated the significant improvement in clinical outcome from adding hyperthermia to standard treatment regimens of radiation and/or chemotherapy [26][27][28][29][30][31][32][33][34] . Maluta, et al 37,38) .…”

Section: - -mentioning

confidence: 99%

Thermal Therapy as Multidisciplinary Therapy Applied to Rectal Cancer:

et al. 2017

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To avoid colostomy, we try to improve local control, i.e. to perform pathological complete response (pCR) by the neoadjuvant chemoradiation (NACR) with concurrent thermal therapy, falling into a so-called "wait-and-see policy". The aim of this study is examined whether the treatment response of NACR with concurrent thermal therapy for rectal cancer can be predicted after the treatment completion and we showed the changing history of our treatment protocol, current results of our study and a new perspective and potential role of thermal therapeutic approaches in patients with rectal cancer. In this study, 81 patients with rectal cancers (54 resected, M:F＝61:20, median age 63 years old (33-89), from December 2011 to May 2015) were received intensity-modulated radiotherapy (IMRT) (total dose 50 Gy/25 fractions) with capecitabine (1,700 mg/m 2 / day) for five weeks. Thermal therapy was performed using the Thermotron-RF 8, once a week for 5 weeks with 50 min irradiation. Clinical complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were shown in 33.4%, 38.3%, 12.3%, and 16.0% of the patients, respectively. Patients with a gross tumor volume (GTV) ≤ 32 cm 3 and a radiofrequency (RF) output difference (RO difference) ≥ 0 Watt/min exhibited the rates of pathological complete response (pCR) 42.9% and complete response (CR) 71.4%, and those with RO difference＜0 Watt/min, 23.1% and 92.3%, respectively. While, patients with a GTV ≥ 80 cm 3 and a RO difference ≥ 0 Watt/min exhibited the rates of pCR and CR 23.1% and 30.8%, and those with RO difference＜0 Watt/min, 0% and 0%, respectively. Skin temperature significantly changed in patients with a pathological grade 3 tumor compared both to those who had PD and other outcomes, in the Therapeutic potential of thermal therapy H. Shoji et al. 75- -

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Current state of the art of regional hyperthermia treatment planning: a review

Cited by 138 publications

References 110 publications

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

Thermoradiotherapy planning: Integration in routine clinical practice

Thermal Therapy as Multidisciplinary Therapy Applied to Rectal Cancer:

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