Current state of research in the field of buccal dosage forms and possibility of using dipyridamole as a subbuccal gel (Review article)

Abstract

Buccal route of drug administration (from Latin «bucca» — the cheek) is the introduction of drugs into the body through the mucous membrane of the inner side of the cheek. The oral mucosa, including the cheeks, has a high absorption capacity. In this case, the absorbed drug substance enters directly into the systemic bloodstream, bypassing the liver, which ensures the rapid development of the effect with high bioavailability of the drug. To hold the medicine on the buccal mucosa, special dosage forms are used, i.e. cheek plates with the medicinal substance. Purpose of the work: to summarize the available literature data on buccal dosage forms and the possibilities of their use. Materials and methods. We conducted a literature review of scientific papers over the last 20 years in the resources of the PubMed and eLIBRARY search engines using the key words below. For this meta-analysis, we used articles that provided evidence on the most current issues related to buccal dosage forms. Results. It has been established that the buccal route of administration is promising and has undeniable advantages. The list of available drugs included in this dosage form is limited. The introduction of dipyridamole into a subbuccal gel is a promising way to expand the range of dosage forms (DF) of dipyridamole, represented only by film-coated tablets and a suspension for oral administration (Rosemont Pharmaceuticals Ltd, UK). Conclusion. The result of the research has been the establishment of prospects for expanding the range of dosage forms through the development of a subbuccal gel with dipyridamole.