Current state of cancer patient care incorporating Thai traditional medicine in Thailand: A qualitative study

Nootim, Preecha; Kapol, Nattiya; Bunchuailua, Waranee; Poompruek, Panoopat; Tungsukruthai, Parankul

doi:10.1016/j.joim.2019.12.004

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…Even though the authors investigated Thai rejuvenating remedy No. 11 for the first time, the anti-pigmentation properties of both bioactive metabolites (glabridin and ethyl p -methoxycinnamate) found in the remedy were already reported before by Chen et al 2016 and Ko et al 2014 [ 2 , 3 ]. However, it does not mean that the authors’ results lack novelty since both studies investigated the activity of each metabolite as a pure component and studied them separately.…”

Section: Discussionsupporting

confidence: 55%

“…Typically, each Thai rejuvenating remedy consists of a specific medicinal plant mixture in various proportions, and each unique remedy claims specific therapeutic properties. An idea of a complex herbal mixture is based on a holistic medical concept used by traditional Thai medicine practitioners [ 3 ]. However, this concept is challenging when applying a modern scientific approach, such as reductionism [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

et al. 2023

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Thai rejuvenating remedies are mixed herbal formulas promoting longevity. Due to the complexity, the biological activities of these remedies are minimal. Therefore, in this study, the authors evaluated the anti-pigmentation effect at the molecular level of the selected Thai rejuvenating remedy to fulfill the knowledge gap. First, the authors found that the selected remedy showed promising activity against the tyrosinase enzyme with an IC50 value of 9.41 µg/mL. In the comparison, kojic acid (positive control) exhibited an IC50 value of 3.92 µg/mL against the same enzyme. Later, the authors identified glabridin as a bioactive molecule against tyrosinase with an IC50 value of 0.08 µg/mL. However, ethyl p-methoxycinnamate was the most abundant metabolite found in the remedy. The authors also found that the selected remedy and glabridin reduced the melanin content in the cell-based assay (B16F1) but not in the zebrafish larvae experiment. Finally, the authors conducted a computational investigation through molecular docking proposing a theoretical molecular interplay between glabridin, ethyl p-methoxycinnamate, and target proteins (tyrosinase and melanocortin-1 receptor, MC1R). Hence, in this study, the authors reported the molecular anti-pigmentation mechanism of the selected Thai rejuvenating remedy for the first time by combining the results from in silico, in vitro, and in vivo experiments.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

et al. 2023

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“…In Thailand, CAMs such as Thai traditional medicine, Thai herbs, Thai massage, acupuncture, and cannabis were promoted by the Thai government [ 18 ]. Thailand has been the first country in Southeast Asia allowing the use of medical cannabis since December 2018.…”

Section: Introductionmentioning

confidence: 99%

The Use of Complementary and Alternative Medicine in Thai Gynecologic Oncology Patients: Influencing Factors

Chukasemrat

Charakorn

Lertkhachonsuk

2021

Evidence-Based Complementary and Alternative Medicine

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Background. To determine the factors influencing the use of complementary and alternative medicine (CAM) in gynecologic cancer patients and the prevalence and pattern of CAM use. Methods. This was a cross-sectional study of 370 gynecologic cancer patients conducted at the outpatient clinic, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. After obtaining informed consent, participants were asked to complete a standardized questionnaire including sociodemographic and clinical characteristics, detail of CAM use, attitude of CAM use, and quality of life using EORTC-QLQ-C30. Results. The prevalence of CAM use was 25.13%. The most common type was herbal medicine (55.90%). The participants who resided or had a birthplace in rural areas presented with a higher proportion of CAM use than those in urban areas ( P = 0.470 and P = 0.004 , respectively). Participants who received multiple modalities of cancer treatment reported a significantly higher proportion of CAM use ( P = 0.024 ). Most CAM users agreed that the CAM could be used in combination with standard treatment, and some rather disagreed that CAM could interrupt the treatment effect of the conventional treatment. CAM users had significantly higher role functioning in quality-of-life scores. Conclusion. Factors influencing CAM use in gynecologic cancer patients were rural area birthplace or residency, receiving multiple modalities of cancer treatment, having positive attitude toward CAM use. CAM users had better performance in role functioning in the quality-of-life score. Therefore, gynecologic oncologists should pay attention to these factors in order to communicate with gynecologic cancer patients about CAM use.

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“…Phytotherapy and traditional medicine have been widely applied in treating various of diseases [ 133 , 134 ]. They are natural, with relatively low irritation and side effects on the human body, and can also be utilized in combination with other treatment [ 135 , 136 ].…”

Section: Discussionmentioning

confidence: 99%

Potential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors

Wang,

Lu,

Ling

et al. 2023

Nutrients

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Breast cancer (BC) is a lethal malignancy with high morbidity and mortality but lacks effective treatments thus far. Despite the introduction of immune checkpoint inhibitors (ICIs) (including PD-1/PD-L1 inhibitors), durable and optimal clinical benefits still remain elusive for a considerable number of BC patients. To break through such a dilemma, novel ICI-based combination therapy has been explored for enhancing the therapeutic effect. Recent evidence has just pointed out that the HDAC2 inhibitor (HDAC2i), which has been proven to exhibit an anti-cancer effect, can act as a sensitizer for ICIs therapy. Simultaneously, dietary intervention, as a crucial supportive therapy, has been reported to provide ingredients containing HDAC2 inhibitory activity. Thus, the novel integration of dietary intervention with ICIs therapy may offer promising possibilities for improving treatment outcomes. In this study, we first conducted the differential expression and prognostic analyses of HDAC2 and BC patients using the GENT2 and Kaplan–Meier plotter platform. Then, we summarized the potential diet candidates for such an integrated therapeutic strategy. This article not only provides a whole new therapeutic strategy for an HDAC2i-containing diet combined with PD-1/PD-L1 inhibitors for BC treatment, but also aims to ignite enthusiasm for exploring this field.

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Current state of cancer patient care incorporating Thai traditional medicine in Thailand: A qualitative study

Cited by 7 publications

References 10 publications

In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

The Use of Complementary and Alternative Medicine in Thai Gynecologic Oncology Patients: Influencing Factors

Potential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors

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