Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Wang, Xueke; Kang, Meisong; Li, Chun; Lin, Ting; Han, Xiao; Jiang, Xiwen

doi:10.3389/fcimb.2021.714895

Cited by 9 publications

(12 citation statements)

References 59 publications

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“…Apart from that, with the increase in abuse of alcohol and the prevalence of non-alcoholic fatty liver disease, HCC is becoming a huge threat to the health of human beings ( 2 – 4 ). Considering the prevalence of hepatitis B virus infection in China, HCC is also one of the top dangers in China ( 5 ). Currently, the application of small molecular inhibitors, immune checkpoint inhibitors, and new technologies in locoregional therapy has improved the prognosis of HCC patients to some extent ( 6 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Exosomes From Cancer-Associated Mesenchymal Stem Cells Transmit TMBIM6 to Promote the Malignant Behavior of Hepatocellular Carcinoma via Activating PI3K/AKT Pathway

Shang

Liu

et al. 2022

Front. Oncol.

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ObjectiveCancer-associated mesenchymal stem cells (MSCs) regulate the progression of cancers through exosome-delivered components, while few studies are conducted on hepatocellular carcinoma (HCC). This study aimed to evaluate the effect of exosomes from HCC-associated MSCs (HCC-MSCs) on HCC cellular functions and the potential regulatory mechanism.MethodsHCC cells (Huh7 and PLC) were cultured normally or co-cultured with HCC-MSCs, HCC-MSCs plus GW4869, or HCC-MSC-derived exosomes; then mRNA sequencing and RT-qPCR validation were conducted. Subsequently, candidate genes were sorted out and modified in HCC cells. Next, TMBIM6-modified HCC-MSCs were used to treat HCC cells.ResultsBoth HCC-MSCs and their derived exosomes promoted proliferation, invasion, sphere formation ability but suppressed apoptosis in HCC cells (all p < 0.05); however, the effect of HCC-MSCs on these cellular functions was repressed by exosome inhibitor (GW4869). Subsequently, TMBIM6, EEF2, and PRDX1 were sorted out by mRNA sequencing and RT-qPCR validation as candidate genes implicated in the regulation of HCC cellular functions by HCC-MSC-derived exosomes. Among them, TMBIM6 had a potent effect (all p < 0.05), while EEF2 and PRDX1 had less effect on regulating HCC cell viability and invasion. Next, direct silencing TMBIM6 repressed viability, sphere formation, invasion, epithelial–mesenchymal transition (EMT), and PI3K/AKT pathway but promoted apoptosis in HCC cells; however, overexpressing TMBIM6 showed the opposite effect. Furthermore, incubating with exosomes from TMBIM6-modified HCC-MSCs presented a similar effect as direct TMBIM6 modification in HCC cells.ConclusionHCC-MSC-derived exosomes transmit TMBIM6 to promote malignant behavior via PI3K/AKT pathway in HCC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Exosomes From Cancer-Associated Mesenchymal Stem Cells Transmit TMBIM6 to Promote the Malignant Behavior of Hepatocellular Carcinoma via Activating PI3K/AKT Pathway

Shang

Liu

et al. 2022

Front. Oncol.

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“…LncRNAs have been linked to HCC caused by HBV infection (Zhang et al, 2014;Wang et al, 2021). The lncRNA DLEU2 is induced to be transcribed by HBx in HBV-infected cells, leading to an increase in DLEU2 levels in infected hepatocytes.…”

Section: Neat1mentioning

confidence: 99%

The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma

Hong

Zhang

Zhao

et al. 2022

Front. Cell Dev. Biol.

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Hepatocellular carcinoma (HCC) is the most frequent and deadly type of liver cancer. While the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs may play key roles. Many HCC-associated lncRNAs have been linked to HBV and HCV infection, mediating gene expression, cell growth, development, and death. Studying the regulatory mechanisms and biological functions of HCC-related lncRNAs will assist our understanding of HCC pathogenesis as well as its diagnosis and management. Here, we address the potential of dysregulated lncRNAs in HCC as diagnostic and therapeutic biomarkers, and we evaluate the oncogenic or tumor-suppressive properties of these lncRNAs.

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“…LncRNAs participate in the hallmarks of cancer (e.g., sustained proliferation, apoptosis escape, enhanced angiogenesis, and increased invasive ability) by binding to DNA, RNA or protein, or by encoding small peptides (Chang et al 2016 ; Huang et al 2020 ; Zuo et al 2020 ). The role of most lncRNAs in HCC are currently unknown, but their unique properties suggest they may be useful in the diagnosis and treatment of HCC (Wang et al 2021a ). LncRNAs play key roles in regulating the liver microenvironment and chronic liver disease, including the regulation of immune responses, liver regeneration and oxidative stress (Huang et al 2020 ; Wei et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Development of a novel lncRNA-derived immune gene score using machine learning-based ensembles for predicting the survival of HCC

Cai,

Li,

Zhu

et al. 2024

J Cancer Res Clin Oncol

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Background Long noncoding RNAs (lncRNAs) are implicated in the tumor immunology of hepatocellular carcinoma (HCC). Methods HCC mRNA and lncRNA expression profiles were used to extract immune-related genes with the ImmPort database, and immune-related lncRNAs with the ImmLnc algorithm. The MOVICS package was used to cluster immune-related mRNA, immune-related lncRNA, gene mutation and methylation data on HCC from the TCGA. GEO and ICGC datasets were used to validate the model. Data from single-cell sequencing was used to determine the expression of genes from the model in various immune cell types. Results With this model, the area under the curve (AUC) for 1-, 3- and 5-year survival of HCC patients was 0.862, 0.869 and 0.912, respectively. Single-cell sequencing showed EREG was significantly expressed in a variety of immune cell types. Knockdown of the EREG target gene resulted in significant anti-apoptosis, pro-proliferation and pro-migration effects in HepG2 and HUH7 cells. Moreover, serum and liver tissue EREG levels in HCC patients were significantly higher than those of healthy control patients. Conclusion We built a prognostic model with good accuracy for predicting HCC patient survival. EREG is a potential immunotherapeutic target and a promising prognostic biomarker.

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Current State and Progress of Research on the Role of lncRNA in HBV-Related Liver Cancer

Cited by 9 publications

References 59 publications

RETRACTED: Exosomes From Cancer-Associated Mesenchymal Stem Cells Transmit TMBIM6 to Promote the Malignant Behavior of Hepatocellular Carcinoma via Activating PI3K/AKT Pathway

RETRACTED: Exosomes From Cancer-Associated Mesenchymal Stem Cells Transmit TMBIM6 to Promote the Malignant Behavior of Hepatocellular Carcinoma via Activating PI3K/AKT Pathway

The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma

Development of a novel lncRNA-derived immune gene score using machine learning-based ensembles for predicting the survival of HCC

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