Reduced spinal mobility may result in activity limitations and participation restrictions, which could subsequently affect quality of life. This literature review examined the effects of aging on spinal range of motion (ROM). Two databases (PubMed and Google Scholar) were searched using the MeSH terms spine, aging, range of motion, athlete, human and collagen. Two hundred twenty-four articles were identified; 210 of these were rejected as not directly relevant with the current review. The accepted articles (n=14) were categorized into four participant groups (athletes, clinical, elderly, and general). Each of the studies was analyzed and assigned a quality grade using the GRADE system provided by the American Dietetic Association. The results suggested that aging causes increased risk for spinal fractures and loss of ROM and bone density. For women, spinal deformity and vertebral compression fractures may lead to impaired mobility and quality of life. More research is needed on the effects of the aging spine in relation to overall health, quality of life and socio-economic status.