Current situation on fertility preservation in cancer patients in Spain: Level of knowledge, information, and professional involvement

Garrido-Colino, Carmen; Lassaletta, Álvaro; Vázquez, María Ángeles Rodríguez; Echevarria, Aizpea; Gutierrez, Ignacio; Andión, Maitane; Berlanga, Pablo

doi:10.1016/j.anpede.2016.04.010

Cited by 4 publications

(11 citation statements)

References 27 publications

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“…The papers on the outlook of HCPs either provided information regarding the practice 49 , 50 , 51 , 52 , 53 or yielded tangible results 31 , 40 , 54 , 55 (Table S3 ). Seventy‐two percent of HCPs stated having discussed potential infertility with the patients 31 and 40% with the parents of children under 18 years of age.…”

Section: Resultsmentioning

confidence: 99%

“… 30 , 31 FP options were presented before the beginning of treatment in 2/9 papers. 49 , 50 Only selected patients were referred to a fertility specialist: only pubescents, 51 more frequently boys (66%) than girls (23%), 50 and sometimes only when patients and parents expressed concerns regarding infertility. 51 In practice, referral was observed in 12% to 49% of cases, 30 , 40 , 54 which corresponded to the proportion of patients who underwent FP.…”

Section: Resultsmentioning

confidence: 99%

“…Apart from breast cancer which was borderline data considering the focus of this review on CCS, there was no link between the type of cancer and the fertility discussion. Some factors stood out as facilitators as well as barriers for both patients and HCPs: the general health status, 29,40,[49][50][51][59][60][61] the desire to have children, [48][49][50]56,58,59 the parent's support to discuss fertility and perform FP, 35,40,49,50,52,55,56,62 the availability of FP services, 31,34,40,49,51,53,55,[57][58][59]61,63 the HCP's assumptions, 35,40,49,50,[55][56][57][58][59] and comfortability to discussing fertility. 31,35,40,49,50,…”

Section: Facilitators and Barriers To The Fertility Discussionmentioning

confidence: 99%

“…FP. 40,54 Overall, even a routine practice such as sperm banking, was proposed in 54% to 96% of pubescent patients, 31,40,[50][51][52][53][54][55] with a very heterogeneous success rate (44% to 79%). 31,40,55 Interestingly, Chong et al 40 pointed out the loss of patients throughout the course of the banking process, from 85/172 referred patients, 38/85 agreeing to have tissue collected, and ultimately 30/38 to successfully banking.…”

Section: Hcpsmentioning

confidence: 99%

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Fertility discussions and concerns in childhood cancer survivors, a systematic review for updated practice

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Facilitators and Barriers To The Fertility Discussionmentioning

confidence: 99%

Section: Hcpsmentioning

confidence: 99%

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Fertility discussions and concerns in childhood cancer survivors, a systematic review for updated practice

et al. 2022

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“…Among these are hepatotoxicity, nephrotoxicity and lung toxicity. Additionally, high therapeutic doses of CP caused a lethal cardiotoxicity [6][7][8][9][10][11]. The main molecular mechanism of CP toxicity is due to the production of highly reactive oxygen free radicals by the metabolites phosphoramide and acrolein.…”

Section: Introductionmentioning

confidence: 99%

Using an <i>Escherichia Coli</i> K-12/<i>recA-gfpmut2</i> Microbial Biosensor to Assess the Impact of Cyclophosphamide and L-ascorbic Acid Residues on Living Bacteria Cells

Matejczyk¹,

Świsłocka²,

Lewandowski³

2020

Pol. J. Environ. Stud.

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Pharmaceutical residues and their transformation products (TPs) have been found in wastewaters and aquatic environments, and they cause adverse effects in aquatic organisms, especially upon chronic exposure and even at very low doses. Cyclophosphamide (CP) is a common alkylating agent that is effective against a wide variety of tumors. L-ascorbic acid is a known water-soluble vitamin that has antioxidant properties. The pharmaceutical residues of both drugs are detected in the environment, and as biologically active molecules they have the ability to affect organisms. In this work we presented the use of a microbiological biosensor E. coli K-12/recA-gfpmut2 in the assessment of the effects of residues of cyclophosphamide and vitamin C and their mixtures on living cells. In our studies, we have shown that mixtures of CP and vitamin C in the highest CP concentrations are more toxic to E. coli strain compared to parent chemicals. In addition, we also found that drug mixtures, especially at the highest CP concentrations, more strongly stimulate the recA promoter and gfp gene expression. We showed that an Escherichia coli K-12/recA-gfpmut2 microbial biosensor is a useful tool in assessing the impact of pharmaceutical residues of cyclophosphamide and L-ascorbic acid and their mixture on living bacteria cells. A stronger impact and toxicity of the mixtures of both tested chemical compounds was found in comparison to parent chemicals.

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Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality

Jeelani

Khan

Shaeib

et al. 2017

Free Radical Biology and Medicine

129

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Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and/or its main metabolite, acrolein, affect female fertility remains unclear, but it is thought to be caused by an overproduction of reactive oxygen species (ROS). Here, we investigated the effect of CTX on metaphase II mouse oocytes obtained from treated animals (120mg/kg, 24h of single treatment), and oocytes directly exposed to increasing concentrations of CTX and acrolein (n=480; 0, 5, 10, 25, 50, and 100μM) with and without cumulus cells (CCs) for 45min which correlates to the time of maximum peak plasma concentrations after administration. Oocytes were fixed and subjected to indirect immunofluorescence and were scored based on microtubule spindle structure (MT) and chromosomal alignment (CH). Generation of ROS was evaluated using the Cellular Reactive Oxygen Species Detection Assay Kit. Deterioration of oocyte quality was noted when oocytes were obtained from CTX treated mice along with CTX and acrolein treated oocytes in a dose-dependent manner as shown by an increase in poor scores. Acrolein had an impact at a significantly lower level as compared to CTX, plateau at 10μM versus 50μM, respectively. These variation is are associated with the higher amount of ROS generated with acrolein exposure as compared to CTX (p<0.05). Utilization of antioxidant therapy and acrolein scavengers may mitigate the damaging effects of these compounds and help women undergoing such treatment.

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Current situation on fertility preservation in cancer patients in Spain: Level of knowledge, information, and professional involvement

Cited by 4 publications

References 27 publications

Fertility discussions and concerns in childhood cancer survivors, a systematic review for updated practice

Fertility discussions and concerns in childhood cancer survivors, a systematic review for updated practice

Using an <i>Escherichia Coli</i> K-12/<i>recA-gfpmut2</i> Microbial Biosensor to Assess the Impact of Cyclophosphamide and L-ascorbic Acid Residues on Living Bacteria Cells

Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality

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