Current research on the relevance of electrocardiography in cardiac resynchronization therapy

Chaturvedi, Vivek

doi:10.1016/j.ipej.2015.09.001

Cited by 3 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the 10 patients who, following the implantation, presented a pacing percentage < 95%, 50% of these at the complete follow‐up had a major cardiovascular event. The mean QI in this sample of patients was significantly lower than the general population's mean and was equal to 8.8% 6–9 with a statistically significant difference ( p = .0010).…”

Section: Resultscontrasting

confidence: 58%

“…The mean QRSd decreased after CRT (from 167 ± 25.3 ms at baseline to 145.9 ± 21.5 ms postimplantation, p < .0001). The mean [25th−75th] QI was 13.3% 6–19 . A significant improvement was observed in all echocardiographic parameters at the 6‐month echocardiographic follow‐up (LVESV from 126.5 ± 52.3 mL to 99.53 ± 58.6 mL, p < .0001; LVEDV from 177 ± 61.5 mL to 155 ± 68.4 mL, p < .0001 and LVEF from 29.3 ± 7.4% to 38.9 ± 11%, p < .0001) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…However, it has been established that the narrowing of the QRS duration (QRSd) in absolute terms is related to a positive response to CRT. Postimplantation narrowing of the QRS has been shown to correlate with structural changes in response to CRT and improved outcomes 6–9 . Rickard's group introduced the concept of QRS index (QI) [(native QRS—paced QRS)/native QRS × 100] to estimate the electrical remodeling entity about the initial electrical disturbance entity, reporting a statistically significant association between QI and structural remodeling 10 .…”

Section: Introductionmentioning

confidence: 99%

“…Postimplantation narrowing of the QRS has been shown to correlate with structural changes in response to CRT and improved outcomes. [6][7][8][9] Rickard's group introduced the concept of QRS index (QI) [(native QRS-paced QRS)/native QRS × 100] to estimate the electrical remodeling entity about the initial electrical disturbance entity, reporting a statistically significant association between QI and structural remodeling. 10 Moreover, in the studies already carried out in our center, this index has been validated, which is reliable in predicting the response to CRT.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tighter is better: Can a simple and cost‐free parameter predict response to cardiac synchronization therapy?

Coppola,

Madaudo,

Mascioli

et al. 2024

Pacing Clinical Electrophis

View full text Add to dashboard Cite

BackgroundSeveral studies have evaluated the role of QRS duration (QRSd) or QRS narrowing as a predictor of response to cardiac resynchronization therapy (CRT) to reduce nonresponders.AimOur study aimed to determine the correlation between the relative change in QRS index (QI) compared to clinical outcome and prognosis in patients who underwent CRT implantation.MethodsA three‐centers study involving 398 patients with a CRT device was conducted. Clinical, echocardiographic and pharmacological variables, QRSd before and after CRT implantation and QI were measured.ResultsIn a 6‐month follow‐up, a significant improvement in left ventricular ejection fraction (LVEF), left ventricular end‐diastolic and systolic volumes (LVEDV and LVESV) were observed. QI was related to reverse remodeling (multiple r‐squared: 0.48, adjusted r‐squared: 0.43, p = .001), and the cut‐off value that best predicted LV reverse remodeling after 6 months of CRT was 12.25% (AUC 0.7, p = .001). At 24 months, a statistically significant difference was found between patients with a QI ≤ 12.25% and those with a QI > 12.25% regarding NYHA class worsening (p = .04). The mean of the QI of patients who died from cardiovascular causes was lower than patients who died of other causes (p = .0179). A correlation between pre‐CRT QRSd/LVEDV and QI was observed (r = + 0.20; p = .0003). A higher QRSd/LVEDV ratio was associated with an improved LVEF, LVEDV, and LVESV (p < .0001) at follow‐up.ConclusionsQI narrowing after CRT was related to greater echocardiographic reverse remodeling and a lower rate of adverse events (death or cardiovascular hospitalizations). The QI can improve the prediction of adverse events in a population with CRT regardless of comorbidities according to the Charlson Comorbidity Index. QI could be used to predict CRT response.

show abstract

Section: Resultscontrasting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tighter is better: Can a simple and cost‐free parameter predict response to cardiac synchronization therapy?

Coppola,

Madaudo,

Mascioli

et al. 2024

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

“…However, since the preliminary studies providing benefi ts of CRT, the major concerns have been targeted to the problem of responders' identifi cation Citation: Coppola considering that a signifi cant proportion of implanted patients fails to respond suffi ciently or in a predictable manner. A lot of studies have reported a renewed interest on the role of simple, low cost and easily available electrocardiographic parameters; in particular narrowing of QRS duration has been shown to correlate with favorable structural changes (ventricular volumes, LVEF and even functional mitral regurgitation) tailored by biventricular pacing and outcomes [4][5][6][7]. The "early" identifi cation of potential non responder (before six months as recommended) could help physicians in planning the timing for clinical follow-up and device optimization [8].…”

Section: Introductionmentioning

confidence: 99%

A possible easy way to predict response to cardiac resynchronization therapy: The role of QRS Index

Coppola¹,

Cristina²,

Amedeo³

et al. 2023

J Cardiovasc Med Cardiol

View full text Add to dashboard Cite

Background: Some studies have evaluated the role of QRS duration (QRSd) as predictor of response to Cardiac Resynchronization Therapy (CRT). However, their results are still not entirely clear. The goal of our study was to determine the correlation between the relative change in QRS narrowing index (QI) compared to clinical outcome and prognosis in patients who underwent CRT implantation. Methods: We collected clinical and echocardiographic data of 115 patients in whome a CRT device was implanted in accordance with current guidelines. QRS duration before and after CRT implantation and QI were measured. Results: After 6 months, a significant improvement in all echocardiographic parameters was detected. QI was correlated to reverse remodelling (r = +0.19; 95% CI: 0.006 to 0.35, p = 0,049). The value of QI that predicted best LV reverse remodelling after 6 months of CRT was 12.25% (sensitivity = 65,5%, specificity = 75%, area under the curve = 0.737, p = 0,001). Independent predictors of QI are sex, serum creatinine and eGFR measured at baseline and LVEF pre-CRT performed by echocardiography. We observed an betterment in their HF clinical composite score and NYHA class at 12 months. We have also investigated the clinical outcomes and the possible sex differences related to QI. Conclusions: Patients with a larger QI after CRT initiation showed greater echocardiographic reverse remodelling and better outcome from death or cardiovascular hospitalization. QI seems to be an easy-to- measure variable that could be used or evaluated to predict CRT response but further studies are needed.

show abstract

Non-responders to cardiac resynchronization therapy: Insights from multimodality imaging and electrocardiography. A brief review

Carità

Corrado

Curnis

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

Current research on the relevance of electrocardiography in cardiac resynchronization therapy

Cited by 3 publications

References 10 publications

Tighter is better: Can a simple and cost‐free parameter predict response to cardiac synchronization therapy?

Tighter is better: Can a simple and cost‐free parameter predict response to cardiac synchronization therapy?

A possible easy way to predict response to cardiac resynchronization therapy: The role of QRS Index

Non-responders to cardiac resynchronization therapy: Insights from multimodality imaging and electrocardiography. A brief review

Contact Info

Product

Resources

About