Current Research of the Renin-Angiotensin System Effect on Stem Cell Therapy

Abstract

The renin-angiotensin system (RAS) is a chief regulator of the cardiovascular system and body luid homeostasis. Stem/progenitor cell therapy has pointed towards a novel tool for medical and therapeutic intervention. In addition to the physiological and pathological role of the RAS and its pharmacological inhibitors, the proliferation, diferentiation in stem cells is mediated through various cell-signalling pathways. This book chapter reviews the new role of RAS components, distinct from other common roles by considering its regulating impact on the several signalling pathways involved in diferent body tissues, as well as in stem cell therapy.

Application of Design of Experiment Based Innovative Approach in Method Development and Validation of RP-HPLC for Estimation of Azilsartan in Bulk and Pharmaceutical Tablet Dosage Form

“…[1][2][3] Apart from the role of the RAS in cardiac and renal treatment, it has been shown to meet the trademarks of the cancer. 4 In recent studies it plays an important role in different cancer cells and tissues such as liver, lung, breast and pancreas. 5 During absorption in the gastrointestinal tract, Azilsartan medoxomil is hydrolyzed to Azilsartan i.e.…”