Current Research of Phytochemical, Medicinal and Non-Medicinal Uses of Uncaria gambir Roxb.: A Review

Abstract

Uncaria gambir Roxb. is a plant from Southeast Asia and is widely used as an alternative medicine with various applications. This plant has been widely used in traditional medicine. This paper aims to provide information on U. gambir, a summary of data on phytochemicals and on medical and nonmedical activities. Phytochemical studies reveal biologically active constituents such as flavonoids, phenolics, and alkaloids. Various studies have shown that extracts and compounds obtained from U. gambir have medical uses for their antioxidant, antibacterial, anti-helminthic, anticancer, antifungal, anti-inflammatory, anti-hyperglycemic, anti-hyperuricemic, anti-lipid peroxidation, antihyperlipidemic and other properties. In addition, this extract has other uses, such as adsorbent for dyes and metal ions, as well as corrosion inhibition. Thus, U. gambir, which is commonly used in traditional medicine, is a potential plant for many therapeutic applications and prospects for drug development as well as other applications such as adsorbent and corrosion inhibition.

Analysis of Total Flavonoid Content in the Extract of Bajakah Kalalawit Root (Uncaria gambir Roxb) Infunded Results

“…With continuous improvement in medicinal plant research methods, an increasing number of compounds including alkaloids, flavonoids and tannins have been discovered in the kalalawit plant. Modern studies show that this plant has pharmacological activities such as anticancer, enzyme inhibitors, and hypoglycemic activity due to flavonoid compounds 5 .…”

Effect of post-heat treatment on the UV transmittance, hydrophobicity, and tensile properties of PVA/Uncaria gambir extract blend films

“…Consequently, this leads to a higher level of tensile strength, greater flexibility, and better toughness of the composite material. UGE's natural components, tannins, have the capacity to both absorb and dissipate ultraviolet radiation, which is why it has anti-UV characteristics [ 16 , 25 ]. Due to this mechanism, PVA films can be shielded from UV radiation.…”

GC-MS and LC-MS/MS Analysis of Secondary Metabolites in the Methanolic Extract of Uncaria callophylla Blume ex Korth. Stems

“…The potential for the development of leads from Uncaria continues to grow, particularly in the area of immunomodulatory, anti-inflammatory and vascular-related conditions (Heitzman et al, 2004;Zhang et al, 2015;Qin et al, 2021). Uncaria species that most studied are Uncaria gambir, Uncaria nervosa, Uncaria longiflora, Uncaria tomentosa, Uncaria cordata, Uncaria macrophylla, Uncaria rhynchophylla, and Uncaria hirsuta (Almeida et al, 2022;Munggari et al, 2022;Huang et al, 2021). Uncaria callophylla is one of the Uncaria species that is still under-researched.…”