Current regular aspirin use and mammographic breast density: a cross-sectional analysis considering concurrent statin and metformin use

Acheampong, Teofilia; Argov, Erica J. Lee; Terry, Mary Beth; Rodríguez, Concepción Fernández; Agovino, Mariangela; Wei, Ying; Alithat, Shweta; Tehranifar, Parisa

doi:10.1007/s10552-021-01530-1

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…In the 12 cases of breast cancer in 9 different patients, the median age at diagnosis was 33.5 years (range, 23 to 47 years). Except for two cases with no pathological information, seven (70%) were endocrine receptor (ER)-positive and six (60%), including three with ER co-expression, were human epidermal growth factor receptor 2 (HER2)-positive, showing a higher rate of HER2 expression than the general population [24]. Breast-conserving surgery with adjuvant radiation therapy was performed in three (25%) cases, and the other nine (75%) cases underwent mastectomy (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Li-Fraumeni Syndrome in Korea

Song¹,

Kong²,

Choi³

et al. 2024

Cancer Res Treat

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Purpose Li-Fraumeni syndrome (LFS) is a hereditary disorder caused by germline mutation in <i>TP53</i>. Owing to the rarity of LFS, data on its clinical features are limited. This study aimed to evaluate the clinical characteristics and prognosis of Korean patients with LFS.Materials and Methods Patients who underwent genetic counseling and confirmed with germline <i>TP53</i> mutation in the National Cancer Center in Korea between 2011 and 2022 were retrospectively reviewed. Data on family history with pedigree, types of mutation, clinical features, and prognosis were collected.Results Fourteen patients with LFS were included in this study. The median age at diagnosis of the first tumor was 32 years. Missense and nonsense mutations were observed in 13 and one patients, respectively. The repeated mutations were p.Arg273His, p.Ala138Val, and pPro190Leu. The sister with breast cancer harbored the same mutation of p.Ala138Val. Seven patients had multiple primary cancers. Breast cancer was most frequently observed, and other types of tumor included sarcoma, thyroid cancer, pancreatic cancer, brain tumor, adrenocortical carcinoma, ovarian cancer, endometrial cancer, colon cancer, vaginal cancer, skin cancer, and leukemia. The median follow-up period was 51.5 months. Two and four patients showed local recurrence and distant metastasis, respectively. Two patients died of leukemia and pancreatic cancer 3 and 23 months after diagnosis, respectively.Conclusion This study provides information on different characteristics of patients with LFS, including types of mutation, types of cancer, and prognostic outcomes. For more appropriate management of these patients, proper genetic screening and multidisciplinary discussion are required.

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Section: Discussionmentioning

confidence: 99%