Current progress toward vaccine and passive immunization approaches for Strongyloides spp.

Levenhagen, Marcelo Arantes; Conte, Hélio; Costa-Cruz, Júlia Maria

doi:10.1016/j.imlet.2016.10.005

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…Furthermore, experience with stressful events usually produces depression and anxiety, which often co-exist with insufficient sleep and many chronic diseases. [20,21] A highly significant relationship is demonstrated between insufficient sleep and frequent mental distress (FMD), also between FMD and chronic disease. [22,23] In addition, considerable data proposed that chronic mental distress can lead to changes in appetite-regulating hormones and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady

et al. 2017

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Rationale:Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes.Patient concerns:A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding.Diagnoses:The data from physical examination and laboratory tests exhibited as follows: glutamic acid decarboxylase antibody (GADA) = 63.83 U/mL, the fasting blood glucose (FBG) = 13.3 mmol/L, and glycated haemoglobin (HbA1c) = 10.9%. According to levels of GADA, the patient was diagnosed as LADA.Interventions:The patient was clinically treated with insulin for 3-month. Then, running, diet-control, and emotional treatment were combined, such as the patient started a new relationship.Outcomes:An emotional recovery initiated from a new romantic relationship and a baby, showing normal levels of GAD65 (27.007 IU/mL) and FBG (5.46) mmol/L.Lessons:The emotional exhaustion might play a significant role in induction of LADA. It is important that individuals should maintain optimism, cheer, and a positive attitude.

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Section: Discussionmentioning

confidence: 99%

Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady

et al. 2017

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“…Recent research on the development of vaccines against parasites has been documented (Epstein and Richie, 2013; Levenhagen et al ., 2016; Reed et al ., 2016). Compared to vaccines with other immunization routes, oral vaccines have many advantages, such as needle-free, cost-saving, labour-saving as well as high-efficiency (Vela Ramirez et al ., 2017).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of immune response toBacillus subtilisspores expressingClonorchis sinensisserpin3

Lin

Sun

et al. 2020

Parasitology

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Clonorchis sinensis (C. sinensis) is one of the most serious food-borne parasites, which can lead to liver fibrosis or cholangiocarcinoma. Effective measures for clonorchiasis prevention are still urgently needed. Bacillus subtilis (B. subtilis) is an effective antigen delivery platform for oral vaccines. Chonorchis sinensis serpin (CsSerpin) was proved to be potential vaccine candidates. In this study, CsSerpin3 was displayed on the surface of B. subtilis spore and recombinant spores were orally administrated to BALB/C mice. CsSerpin3-specific IgA levels in faecal, bile and intestinal mucous increased at 4–8 weeks after the first administration compared with those in control groups. The mucus production and the number of goblet cells in intestinal mucosa elevated in B.s-CotC-CsSerpin3 (CotC, coat protein of B. subtilis spore) spores treated group compared to those in blank control. No significant difference in the activities of glutamic-pyruvic transaminase/ alanine aminotransferase and glutamic oxalacetic transaminase/aspartate aminotransferase were observed between groups. There was no side effect inflammation and observable pathological damage in the liver tissue of mice after administration. Moreover, collagen deposition and Ishak score were statistically reduced in B.s-CotC-CsSerpin3 spores treated mice. In conclusion, B. subtilis spores displaying CsSerpin3 could be investigated further as an oral vaccine against clonorchiasis.

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Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants

Norman

Comeche

Chamorro

et al. 2020

Expert Review of Anti-infective Therapy

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Current progress toward vaccine and passive immunization approaches for Strongyloides spp.

Cited by 4 publications

References 56 publications

Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady

Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady

Evaluation of immune response toBacillus subtilisspores expressingClonorchis sinensisserpin3

Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants

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