Current Progress in Aptasensor for Ultra-Low Level Monitoring of Parkinson’s Disease Biomarkers

Margiana, Ria; Hammid, Ali Thaeer; Ahmad, Irfan; Alsaikhan, Fahad; Jalil, Abduladheem Turki; Tursunbaev, Farkhod; Umar, Fadilah; Romero-Parra, Rosario Mireya; Mustafa, Yasser Fakri

doi:10.1080/10408347.2022.2091920

Cited by 3 publications

(4 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To assess the morphology and mobility of the parasite, the feces sample was emulsified in normal saline. A droplet of normal saline was positioned on the center of the slide, and a slight portion of the stool specimen sample was mixed and emulsified in the saline using a sterile swab stick and examined microscopically using ×10 and ×40 objectives [ 11 – 13 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of IL-17 and IL-35 in patients with giardiasis in Thi-Qar province, Iraq

Hadi

Al-Fahham

et al. 2022

JMedLife

View full text Add to dashboard Cite

Giardia lamblia, Entamoeba histolytica, Cryptosporidium, and Blastocystis are some parasites primarily responsible for human infections. Giardia lamblia, also known as Giardia intestinalis or Giardia duodenalis, is a common pathogenic protozoan found in the human duodenum and jejunum that causes giardiasis. This study collected stool and blood samples from patients with diarrhea aged less than 1 month to 15 years, from September 2020 to December 2020, in Thi-Qar province. Our study aimed to reveal the diagnosis of Giardia lamblia using direct microscopy examination and detect some immunological parameters such as IL-17 and IL-35 in patients infected with giardiasis.

show abstract

Section: Methodsmentioning

confidence: 99%

Evaluation of IL-17 and IL-35 in patients with giardiasis in Thi-Qar province, Iraq

Hadi

Al-Fahham

et al. 2022

JMedLife

View full text Add to dashboard Cite

show abstract

“…The development of easy-of-use electrochemical aptamer-based platforms with a high sensitivity and specificity is probably one of the most promising methods to solve some of the problems regarding fast and cost-effective measurements appropriate for POC diagnostics due to their potential in terms of their portability and novel microfabrication technologies [88][89][90][91].…”

Section: Neurodegenerative Diseases Biomarkersmentioning

confidence: 99%

“…The next aptasensor developed for the detection AβOs, characterized by a lower LOD (0.5 fM) than those previously described [91], was based on a triple-helix aptamer switch (THAS) [123]. A gold electrode was modified with a thiolated aptamer possessing two symmetrical arm segments via a covalent bond.…”

Section: Amyloid β Peptidementioning

confidence: 99%

An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases

Mikuła

Malecka-Baturo

2023

Coatings

View full text Add to dashboard Cite

Neurodegenerative diseases (NDs) are becoming a major global health problem. They constitute an incurable diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. There is an enormous unmet demand worldwide for methods for the early detection of ND biomarkers. The complexity of the molecular mechanisms underlying neuronal degeneration as well as the inhomogeneity of the patient population pose a great challenge for the development of early diagnostic tools. Various analytical technologies have been developed to meet this challenge. Among the various approaches reported so far, biosensors are powerful analytical implements that have been applied to detect biomarkers of NDs. Over the past decade, electrochemical aptasensors have been at the forefront of this development not only thanks to their low cost and simple design but also due to advances in nanomaterials modifying the surface of the transducers involved. The design of electrochemical aptasensors for the detection of ND biomarkers such as α-synuclein, amyloid β peptide, tau protein and human cellular prion protein were summarized and compared. Innovative strategies for increasing their sensitivity and selectivity were also pointed out. Undoubtedly, there is still a need for low-cost, fast and easy-to-use systems for the early detection of NDs.

show abstract

“…Along with this, the many unique characteristics of aptamers include, but are not limited to, longer shelf lives, simpler surface modifications, minor batch variations, and cost-effectiveness, which have led to significant efforts toward the development of aptasensors [9,10]. Figure 1 presents a chronological chart of key review article developments over the last decade on a range of important topics starting from the origin of aptamers [6,7] and aptasensors [10], along with pioneering review articles such as aptasensors in clinical diagnostics [11], for multi-analyte detection [12], biomedical applications of quantum dots [13], nanoparticles application in high-sensitive aptasensor design [14], aptasensors for organic pollutants and food and environment monitoring [15,16], aptasensors for prostate-antigen detection [17], disease-associated analyses of aptasensors [18], cytokine detection [19], and a recent article on Parkinson's disease-biomarkers-based aptasensors [20]. It is evident from this analysis that this review article is timely and needed to fill in the gap for a detailed analysis on recent advances and applications of specialized detection strategies that have gained less attention in the field of apta-biosensors, along with presenting a perspective and future directive for presenting the readers with a comprehensive review.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Based Optical and Electrochemical Sensors: A Review

Farid,

Ghosh,

Dutta

et al. 2023

Chemosensors

View full text Add to dashboard Cite

There is a pressing need to identify recent directions in the field of aptamer-based sensing. DNA aptamers that are synthetically generated by in vitro selection mechanisms using the SELEX technique are single-stranded oligonucleotides which are selected to bind to a target with favorable sensitivity and selectivity. These aptamers have attracted significant attention due to their high binding affinity and ability to be easily engineered and provide various detection modes in what are known as aptasensors. Our aim is to focus on specialized detection strategies that have gained less attention but are of vital importance, such as optical detection in live cells, fluorescence polarization sensing, multi-analyte detection, colorimetric bioassays, wavelength shifting, and electrochemical-based detection. This will provide us with a perspective to facilitate developments in aptasensor technology for various targets, promising a bright future for biological receptors in the field of biosensing.

show abstract

Current Progress in Aptasensor for Ultra-Low Level Monitoring of Parkinson’s Disease Biomarkers

Cited by 3 publications

References 120 publications

Evaluation of IL-17 and IL-35 in patients with giardiasis in Thi-Qar province, Iraq

Evaluation of IL-17 and IL-35 in patients with giardiasis in Thi-Qar province, Iraq

An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases

Aptamer-Based Optical and Electrochemical Sensors: A Review

Contact Info

Product

Resources

About