Current Progress and Future Perspectives on the Use of Bacillus clausii

Ghelardi, Emilia; Abreu, A.T. Abreu y; Marzet, Christian Boggio; Calatayud, Guillermo Álvarez; Perez, Marcos III; Castro, Ana Paula Moschione

doi:10.3390/microorganisms10061246

Cited by 23 publications

(15 citation statements)

References 109 publications

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“…Due to the ability to form spores, bacteria of this genus are resistant to aggressive environmental factors; therefore, they are widespread in nature (in soil, air, and water). Th ey can be found in the food and body of humans and animals [9,10].…”

Section: Results Th E Formation Of Bacterial Vaginitis In the Balb/c ...mentioning

confidence: 99%

“…Th eir specifi c feature is a strain-related multifactorial biological eff ect, specifi cally (i) marked antagonism to a wide range of pathogenic and conditionally pathogenic microorganisms, pathogens of infectious diseases of humans and animals, (ii) the ability to synthesize compounds diff erent in the nature and mechanism of their antimicrobial activity, as well as enzymes, amino acids, polysaccharides, vitamins, etc. [8,11], and (iii) immunomodulatory properties [10]. Th erefore, bacteria of the genus Bacillus have been used as probiotics for more than 55 years and remain one of the most promising groups of microorganisms for the development of new therapeutic and prophylactic antimicrobial drugs for clinical and veterinary practice.…”

Section: Results Th E Formation Of Bacterial Vaginitis In the Balb/c ...mentioning

confidence: 99%

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Antimicrobial and Immunomodulatory Action of Probiotic Composition of Bacilli on Bacterial Vaginitis in Mice

et al. 2023

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The purpose of this study was to investigate the antimicrobial and immunomodulatory action of a probiotic composition of Bacillus subtilis and B. megatherium strains (UnicaUro, Sirion (Ukraine)) for experimental bacterial vaginitis. Methods. Experimental studies were conducted on female BALB/c mice; we used Staphylococcus aureus strain B-918 (ATCC 6538) to induce bacterial vaginitis. The strain was vaginally introduced into mice before treatment with probiotic bacteria. In the vagina of mice, aerobic and optionally anaerobic bacteria, including representatives of the genera Staphylococcus, Streptococcus, Lactobacillus, Bifidobacterium, Pseudomonas, coliform bacteria, and microscopic fungi were identified in different periods of observation using generally accepted microbiological methods. Serum antibody titer to S. aureus was determined by the bacterial agglutination reaction. The phagocytic activity and oxygen-dependent bactericidal activity of peritoneal exudate macrophages (PEM) were evaluated using generally accepted immunological methods. Results. The formation of bacterial vaginitis in the BALB/c mice line infected with S. aureus B-918 (ATCC 6538) was evidenced by the appearance of external clinical manifestations of the infectious and inflammatory process against the background of the increased number of aerobic and optionally anaerobic microorganisms, including representatives of the genus Staphylococcus and Streptococcus, microscopic fungi, and decreased number of lactobacilli in different observation periods. The probiotic introduction to mice with bacterial vaginitis led to a dynamic change in the vaginal microbiota: the number of aerobic and optionally anaerobic microorganisms decreased, primarily due to the normalization of the number of representatives of Staphylococcus genus accompanied by a decrease in the antibody titer to staphylococcus in the blood serum. The effective therapeutic action of the probiotic was confirmed by the gradual disappearance of the external clinical signs of the infectious-inflammatory process in the vagina against the background of the functional activity of PEM. Conclusions. The probiotic composition of B. subtilis and B. megatherium (UnicaUro, Sirion, Ukraine) is a promising antimicrobial formulation that may be used in the treatment of bacterial vaginitis; however, further studies are required to confirm its therapeutic, antimicrobial, and immunomodulatory efficacy.

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Section: Results Th E Formation Of Bacterial Vaginitis In the Balb/c ...mentioning

confidence: 99%

Section: Results Th E Formation Of Bacterial Vaginitis In the Balb/c ...mentioning

confidence: 99%

Antimicrobial and Immunomodulatory Action of Probiotic Composition of Bacilli on Bacterial Vaginitis in Mice

et al. 2023

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“…This ability to produce spores is more effective in the gut than in other traditional species (Shinde et al., 2019; Zhao et al., 2023). Because spores can survive for years in a dormant state and can germinate rapidly after stimulation in the environment of the gut (e.g., the small intestine, which contains various types of nutrients), this may also be the mechanism by which B. smithii fights infection (Antequera‐Gómez et al., 2021; Ghelardi et al., 2022). Moreover, Bacillus can complete germination and re‐spore production in the gastrointestinal tract through five stages.…”

Section: Application Status and Concernsmentioning

confidence: 99%

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Zhao,

Huang,

Liu

et al. 2024

Comp Rev Food Sci Food Safe

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Bacillus smithii is a thermophilic Bacillus that can be isolated from white wine, hot spring soil, high‐temperature compost, and coffee grounds, with various biofunctions and wide applications. It is resistant to both gastric acid and high temperature, which makes it easier to perform probiotic effects than traditional commercial probiotics, so it can maintain good vitality during food processing and has great application prospects. This paper starts with the taxonomy and genetics and focuses on aspects, including genetic transformation, functional enzyme production, waste utilization, and application in the field of food science as a potential probiotic. According to available studies during the past 30 years, we considered that B. smithii is a novel class of microorganisms with a wide range of functional enzymes such as hydrolytic enzymes and hydrolases, as well as resistance to pathogenic bacteria. It is available in waste degradation, organic fertilizer production, the feed and chemical industries, the pharmaceutical sector, and food fortification. Moreover, B. smithii has great potentials for applications in the food industry, as it presents high resistance to the technological processes that guarantee its health benefits. It is also necessary to systematically evaluate the safety, flavor, and texture of B. smithii and explore its biological mechanism of action, which is of great value for further application in multiple fields, especially in food and medicine.

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“…Probiotics preparations based on B. clausii strains are widely diffused in the market to treat diarrhea and gut dysbiosis. Furthermore, B. clausii can produce riboflavin (vitamin B2), an essential vitamin whose deficiencies in humans are associated with pathologic status sustaining and sustained by various diseases [67].…”

Section: Bacillimentioning

confidence: 99%

Use of Probiotics for Oral Candidiasis: State of the Art and Perspective. A Further Step Toward Personalized Medicine?

Contaldo¹

2023

Front. Biosci. (Elite Ed)

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Oral candidiasis is an opportunistic infection conventionally treated with antifungal drugs. However, the increasing number of fungal infections, parallel to the rising conditions sustained by non-albicans species, pose critical issues related to escalating drug resistances differently acquired by different species. Meanwhile, the knowledge of the interplay between oral microbiota and its host suggests alternative antifungal therapies based on the administration of probiotics. Probiotics are live microorganisms beneficial to the host, and literature reports consistent evidence for their use to treat gut diseases. The present work aimed to overview the primary mechanisms through which probiotics act against Candida species and the current status of knowledge on their use in clinical practice, particularly concerning oral candidiasis.

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Current Progress and Future Perspectives on the Use of Bacillus clausii

Cited by 23 publications

References 109 publications

Antimicrobial and Immunomodulatory Action of Probiotic Composition of Bacilli on Bacterial Vaginitis in Mice

Antimicrobial and Immunomodulatory Action of Probiotic Composition of Bacilli on Bacterial Vaginitis in Mice

Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends

Use of Probiotics for Oral Candidiasis: State of the Art and Perspective. A Further Step Toward Personalized Medicine?

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