Current problematic and emergence of carbapenemase-producing bacteria: a brief report from a libyan hospital

Abstract

A collection of 94 Gram-negative bacteria isolates, showing different antimicrobial resistance phenotypes including to the carbapenem classes was investigated. Strains were originated form clinical sources from a single hospital in Tripoli, Libya during 2015 and were identified based on cultural and phenotypic characteristics, and fully characterized by the VITEK automated system. Forty-eight percent (48%) of the collection was identified as Acinetobacter baumannii, 50% Klebsiella pneumoniae and 2% Escherichia coli. Resistance to the carbapenem classes was reported in 96% of the A. baumannii strains and 94% of the K. pneumonia strains. Seventy-eight percent (78%) of the isolates showed different multidrug-resistant (MDR) phenotypes, of which K. pneumoniae expressing the highest rates of MDRs(i.e. 91%). Emergence of resistance to carbapenems in the Gram-negative bacteria is a challenging global problem, particularly for Africa. Surveillance of these pathogens and appropriate actions are urgently required in Libyan healthcare settings.

Prevalence of pathogenic Klebsiella pneumoniae based on PCR capsular typing harbouring carbapenemases encoding genes in Uganda tertiary hospitals

“…However, a similar study at MBRRH detected lower phenotypic prevalence of 12.6% [ 25 ]. Contrary to this, studies in North Africa and West Africa reported remarkably higher phenotypic resistance of > 50% and K. pneumoniae were the most prevalent isolates [ 26 – 29 ]. Furthermore, a larger study which covered Gauteng, KwaZulu-Natal, Western Cape and Free State provinces in South Africa documented overwhelming phenotypic resistance of between 47 and 50% to imipenem, meropenem and doripenem, 84% and 89% to ertapenem [ 30 , 31 ].…”

Prevalence of Pathogenic Klebsiella Pneumoniae based on PCR Capsular Typing Harbouring Carbapenemases Encoding Genes in Ugandan Tertiary Hospitals

“…However, a similar study at MBRRH detected lower phenotypic prevalence of 12.6% [25]. Contrary to this, studies in North Africa and West Africa reported remarkably higher phenotypic resistance of > 50% and K. pneumoniae were the most prevalent isolates [26][27][28][29]. Furthermore, in a larger study which covered Gauteng, KwaZulu-Natal, Western Cape and Free State provinces in South Africa documented overwhelming phenotypic resistance of between 47-50% to Imipenem, Meropenem and Doripenem, 84%…”

Retrospective investigation of enteric illnesses in pet animals

“…antimicrobial susceptibility tests). This is a very serious medical and health concern considering the recent documentation of the alarming emergence of antimicrobial resistance in various bacterial organisms in Libya [9][10][11]. In addition, studies that investigate the role of animals as a source of zoonotic and antimicrobial resistance organisms are rare in/from Libya however, 324 recent evidences have revealed the role of various animal species as a source of emerging bacterial and antimicrobial resistant pathogens such as staphylococci, Salmonella and E.coli 0157 [6,12].…”