Current Practices of Cervical Ripening and Induction of Labour in Intrauterine Foetal Demise: An Observational Study

Abstract

Background Objectives of the current study were to find the most effective method of induction of labour in case of intrauterine foetal death (IUFD), with efficacy described as least induction-to-delivery time, and the agent with the best safety profile, i.e. least maternal complications. Methods This was a prospective observational descriptive study carried out between January and November 2015 in a tertiary care centre. Hundred consecutive cases of IUFD after 20 weeks of gestation requiring induction of labour and fulfilling inclusion criteria were selected. The method of induction decided by each consultant was noted, and results were analysed. As this was a purely observational study, all agents used for induction of labour (misoprostol, dinoprostone gel, intracervical Foley catheter) and all dose variations were included. ResultsThe induction-to-delivery interval was shortest with dinoprostone (12.52 h) followed by Foley catheter (13.28 h) and misoprostol (15.82 h). However, the p value (0.301) was not statistically significant. Misoprostol was used more often in second trimester, while dinoprostone gel was most commonly used in third trimester. Failure

Efficacy and Safety of Mifepristone Followed by Vaginal PGE1 vs PGE2 Gel Alone for Induction of Labor in Late Intrauterine Fetal Demise

“…Our study is in agreement with the prospective study by Gupta S et al 9 in which mean induction-to-delivery interval in mifepristone plus misoprostol group was 9.6 hours. In the study by Amin KV et al, 10 the inductionto-delivery interval with dinoprostone gel was 12.52 hours.…”