Current practice patterns in nodal evaluation and adjuvant treatment of advanced stage endometrioid endometrial cancer: An SGO survey

Parker, Jessica E.; Miller, David S.; Lee, Jessica; Carlson, Matthew J.; Lococo, Salvatore; Lea, Jayanthi

doi:10.1016/j.gore.2020.100620

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…We built on previously published surveys and then used extensive formative research to ensure inclusion of gynecologic oncology specific subject matter. Although our survey response rate was similar to other emailed surveys of SGO members ( Parker et al, 2020 ), there may be concerns about generalizability. Female and early-career members may have been over-represented compared to the general SGO membership ( Goff and Kushner, 2020 ).…”

Section: Discussionmentioning

confidence: 51%

Gynecologic oncology HPV vaccination practice patterns: Investigating practice barriers, knowledge gaps and opportunities for maximizing cervical cancer prevention

Schneiter

Levinson

Rositch

et al. 2022

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 51%

Gynecologic oncology HPV vaccination practice patterns: Investigating practice barriers, knowledge gaps and opportunities for maximizing cervical cancer prevention

Schneiter

Levinson

Rositch

et al. 2022

Gynecologic Oncology Reports

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“…The third limitation was that, considering the outcomes of recent clinical trials, we did not pursue some important factors, including the location of the tumor within the uterus or the type and extent of LN dissection (sentinel LN sampling vs. LN dissection), which may be important factors determining the need for EBRT. Performing LN dissection is another important issue to be investigated [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Pattern of practice for postoperative management of endometrial cancer in Korea: a survey by the Korean Gynecologic Oncology Group and the Korean Radiation Oncology Group (KGOG 2028-KROG 2104)

Lee

Kim

et al. 2023

J Gynecol Oncol

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Objective This study aimed to investigate the current status of postoperative management of uterine endometrial cancer (EC) in Korea. Methods A mail survey was administered to members of the Korean Gynecologic Oncology Group and Korean Radiation Oncology Group. A total of 38 gynecologic cancer surgeons (GYNs) and 31 radiation oncologists (RO) in 43 institutions was responded. The questionnaire consisted of general questions for clinical decision and clinical case questions. The GYN and RO responses were compared using chi-square statistics. Results The 2 expert groups had similar responses for clinical decision based on the results of the Gynecologic Oncology Group (GOG)-249 and Postoperative Radiation Therapy for Endometrial Carcinoma-III trials in the early-stage EC. In contrast, the responses based on GOG-258 results differed, as GYNs most frequently opted for sequential chemotherapy (CTx) and radiotherapy (RT), while ROs preferred concurrent chemoradiotherapy in locally advanced stage (p<0.05). Based on the GOG-258, GYNs preferred CTx alone for adjuvant treatment of serous or clear cell adenocarcinoma histology, whereas ROs advocated for combined CTx and RT (sequential or concurrent). Among the clinical case questions, GYNs were more likely than ROs to choose CTx alone rather than the combination of CTx and RT (sequential or concurrent) as the answers to case questions representing patients with locally advanced stage or unfavorable histology (all p<0.05). Conclusion The present study showed several different opinions of GYNs and ROs regarding adjuvant treatment for EC, particularly for adjuvant RT in advanced stage or unfavorable histology.

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“…The use of adjuvant treatments remains somewhat controversial, partly due to low recurrence rates after surgery alone, although upfront surgery has remained the mainstay of treatment. Pathological evaluation is an important basis for oncologists to choose postoperative adjuvant therapy, especially pathological lymph node evaluation [ 15 ]. Our model can not only effectively stratify the risk of LNM, but also predict a high risk of recurrence in patients without LNM.…”

Section: Discussionmentioning

confidence: 99%

Development of a novel predictive model for lymph node metastasis in patients with endometrial endometrioid carcinoma

2022

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Background Globally, the burden of endometrial endometrioid carcinoma (EEC) increases annually. However, the histological grade of EEC remains unelucidated. We developed a novel model for predicting lymph node metastasis (LNM) in patients with endometrioid carcinoma (EC), which has not been well established. Methods A total of 344 patients with EEC were classified into training (n = 226) and validation (n = 118) cohorts. To develop a nomogram to predict LNM, independent predictors were defined using univariate and multivariate regression analyses. The calibration curve, area under the decision curve analysis (DCA), and receiver operating characteristic curve were used to evaluate the performance of the nomogram. Results Independent predictors of LNM in EC were identified in the univariate analysis, including mitosis; microcystic, elongated, and fragmented patterns; lymphovascular invasion (LVI); necrosis; and high-grade pattern. Mitosis, LVI, and high-grade pattern remained independent predictors of LNM in multivariate analysis. An LNM nomogram that was constructed by incorporating the five predictors showed reliable discrimination and calibration. DCA showed that the LNM nomogram scoring system had significant clinical application value. In addition, a high nomogram score (score > 150) was a significant prognosticator for survival in both LNM-positive and LNM-negative ECs. Conclusions Our novel predictive model for LNM in patients with EC has the potential to assist surgeons in making optimal treatment decisions.

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Current practice patterns in nodal evaluation and adjuvant treatment of advanced stage endometrioid endometrial cancer: An SGO survey

Cited by 4 publications

References 14 publications

Gynecologic oncology HPV vaccination practice patterns: Investigating practice barriers, knowledge gaps and opportunities for maximizing cervical cancer prevention

Gynecologic oncology HPV vaccination practice patterns: Investigating practice barriers, knowledge gaps and opportunities for maximizing cervical cancer prevention

Pattern of practice for postoperative management of endometrial cancer in Korea: a survey by the Korean Gynecologic Oncology Group and the Korean Radiation Oncology Group (KGOG 2028-KROG 2104)

Development of a novel predictive model for lymph node metastasis in patients with endometrial endometrioid carcinoma

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