Current practice of ototoxicity management across the United Kingdom (UK)

Maru, Devina; Malky, Ghada-Al

doi:10.1080/14992027.2018.1460495

Cited by 33 publications

(32 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, vestibulotoxicity monitoring program is not regularly undertaken in clinical settings [ 22 ]. A flexible and compassionate approach is necessary especially when quantitative vestibular function test is not available or transportation of patients to laboratory setting is not possible.…”

Section: Discussionmentioning

confidence: 99%

“…Direct clinical experience had significant influence on confidence level in diagnosis and management; hence, educational role of more experienced professionals should be promoted. Currently, vestibulotoxicity monitoring program is not regularly undertaken in clinical settings [22]. A flexible and compassionate approach is necessary especially when quantitative vestibular function test is not available or transportation of patients to laboratory setting is not possible.…”

Section: Suggestions For Clinical Practicementioning

confidence: 99%

“…The majority of respondents in that study thought that it was unlikely or slightly likely that balance disturbance would develop after cisplatin treatment. Studies exploring current practice suggested that ototoxic monitoring programs do not seem to be consistently implemented and the protocols vary across clinical settings [21,22]. Cancer patients are not routinely asked about ototoxic effects in an oncology consultation [21,23].…”

Section: Introductionmentioning

confidence: 99%

“…Typically, in the United Kingdom (UK), patients who complain of audiovestibular symptoms are referred either to Otolaryngology or Audiology Department. However, only 10% of audiovestibular professionals in the UK reported that balance assessment was part of ototoxicity monitoring in their centres [22].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

Prayuenyong

Kasbekar

Hall

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals about cisplatin vestibulotoxicity. Methods An online survey was disseminated to clinicians working in the audiovestibular field. Results Ninety-three respondents participated in the survey. Most professionals were aware of potential vestibulotoxicity associated with cisplatin chemotherapy. Thirty-three percent of the respondents reported that they had seen patients with cisplatin vestibulotoxicity. Forty percent of them were confident in making the diagnosis and in managing the patient in this situation. The prevalence and impact of vestibulotoxicity including practicality of the assessment should be considered when designing an effective vestibulotoxicity screening protocol. Conclusion This study provides a better understanding of cisplatin vestibulotoxicity from the perspectives of audiovestibular clinicians, which will underpin appropriate detection and management of the condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Suggestions For Clinical Practicementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

Prayuenyong

Kasbekar

Hall

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…[3][4][5][6][7][8] Despite widespread ototoxic antimicrobial therapy use in chronic lung disease, implementation of national and international ototoxicity monitoring recommendations in the UK is sparce and inconsistent. 9 Within CF, there are a number of studies detailing prevalence of hearing loss through pure-tone audiometry, with rates of ~40% to 56% in adults. 10 When controlling for age, cumulative lifetime intravenous aminoglycoside dosing, had a significant negative effect on hearing.…”

Section: Introductionmentioning

confidence: 99%

Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis

Vijayasingam

Frost

Wilkins

et al. 2020

Thorax

View full text Add to dashboard Cite

IntroductionIndividuals with chronic lung disease (eg, cystic fibrosis (CF)) often receive antimicrobial therapy including aminoglycosides resulting in ototoxicity. Extended high-frequency audiometry has increased sensitivity for ototoxicity detection, but diagnostic audiometry in a sound-booth is costly, time-consuming and requires a trained audiologist. This cross-sectional study analysed tablet-based audiometry (Shoebox MD) performed by non-audiologists in an outpatient setting, alongside home web-based audiometry (3D Tune-In) to screen for hearing loss in adults with CF.MethodsHearing was analysed in 126 CF adults using validated questionnaires, a web self-hearing test (0.5 to 4 kHz), tablet (0.25 to 12 kHz) and sound-booth audiometry (0.25 to 12 kHz). A threshold of ≥25 dB hearing loss at ≥1 audiometric frequency was considered abnormal. Demographics and mitochondrial DNA sequencing were used to analyse risk factors, and accuracy and usability of hearing tests determined.ResultsPrevalence of hearing loss within any frequency band tested was 48%. Multivariate analysis showed age (OR 1.127; (95% CI: 1.07 to 1.18; p value<0.0001) per year older) and total intravenous antibiotic days over 10 years (OR 1.006; (95% CI: 1.002 to 1.010; p value=0.004) per further intravenous day) were significantly associated with increased risk of hearing loss. Tablet audiometry had good usability, was 93% sensitive, 88% specific with 94% negative predictive value to screen for hearing loss compared with web self-test audiometry and questionnaires which had poor sensitivity (17% and 13%, respectively). Intraclass correlation (ICC) of tablet versus sound-booth audiometry showed high correlation (ICC >0.9) at all frequencies ≥4 kHz.ConclusionsAdults with CF have a high prevalence of drug-related hearing loss and tablet-based audiometry can be a practical, accurate screening tool within integrated ototoxicity monitoring programmes for early detection.

show abstract

New insights into cisplatin ototoxicity

Brock

2021

Cancer

View full text Add to dashboard Cite

Lay Summary Platinum‐containing chemotherapy is often used to treat children with cancer. Although it is a very effective medication, unfortunately, it causes permanent hearing loss in more than one‐half of the children who receive it. In this issue of Cancer, an article by Meijer and colleagues shows that very young children are affected early on in their treatment and suggests that the younger the child the more frequently their hearing should be tested during treatment. This proposal is a real challenge for oncology centers and families practically, emotionally, and socioeconomically. The findings are provocative but equally stimulating and encouraging; hopefully, they will lead to a new standard of multidisciplinary care for children receiving platinum chemotherapy.

show abstract

Current practice of ototoxicity management across the United Kingdom (UK)

Abstract: Developing and advocating national guidelines are intended not only to inform clinical decision making but to provide minimum standards of care in ototoxicity management and offer greater awareness and education to improve patients' quality of life.

Cited by 33 publications

References 40 publications

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity

Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis

New insights into cisplatin ototoxicity

Contact Info

Product

Resources

About