Current pharmacotherapy for gambling disorder: a systematic review

Kraus, Shane W.; Etuk, Repairer; Potenza, Marc N.

doi:10.1080/14656566.2019.1702969

Cited by 39 publications

(22 citation statements)

References 88 publications

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“…2 Problem gambling and GD share features with alcohol and substance use disorders, such as clinical manifestation, underlying personality traits and pharmacological treatment options. [3][4][5][6] Moreover, similarities in neurobiological characteristics have been found, for example, altered processing in the brain reward networks. 7 In humans, the Iowa Gambling Task (IGT) is used to study impaired decision-making.…”

Section: Introductionmentioning

confidence: 99%

Functional connectivity in reward‐related networks is associated with individual differences in gambling strategies in male Lister hooded rats

Tjernström

Holst

et al. 2022

Addiction Biology

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Individuals with gambling disorder display deficits in decision-making in the Iowa Gambling Task. The rat Gambling Task (rGT) is a rodent analogue that can be used to investigate the neurobiological mechanisms underlying gambling behaviour. The aim of this explorative study was to examine individual strategies in the rGT and investigate possible behavioural and neural correlates associated with gambling strategies. Thirtytwo adult male Lister hooded rats underwent behavioural testing in the multivariate concentric square field™ (MCSF) and the novel cage tests, were trained on and performed the rGT and subsequently underwent resting-state functional magnetic resonance imaging (R-fMRI). In the rGT, stable gambling strategies were found with subgroups of rats that preferred the suboptimal safest choice as well as the disadvantageous choice, that is, the riskiest gambling strategy. R-fMRI results revealed associations between gambling strategies and brain regions central for reward networks.Moreover, rats with risky gambling strategies differed from those with strategic and intermediate strategies in brain functional connectivity. No differences in behavioural profiles, as assessed with the MCSF and novel cage tests, were observed between the gambling strategy groups. In conclusion, stable individual differences in gambling strategies were found. Intrinsic functional connectivity using R-fMRI provides novel evidence to support the notion that individual differences in gambling strategies are associated with functional connectivity in brain regions important for reward networks.

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Section: Introductionmentioning

confidence: 99%

Functional connectivity in reward‐related networks is associated with individual differences in gambling strategies in male Lister hooded rats

Tjernström

Holst

et al. 2022

Addiction Biology

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“…It has been argued 2 that, if burnout's work-specific context were removed, two of the promulgated symptoms (i.e., depersonalization/cynicism at work, and reduced professional efficacy) would become irrelevant and reduce burnout's definition to exhaustion only. Clinically, however, we observe burnout in individuals not formally employed (e.g., parents looking after children with disabilities, or people caring for elderly relatives with high demands), while others have argued that "work" in the context of burnout should be viewed more broadly 6 . Thus, the context specificity concern is a straw man argument.…”

mentioning

confidence: 64%

“…The high effectiveness of placebo in CSBD may be related to such factors as disclosing the problem, motivation for change, and initiation of therapy while receiving external support from the study team. Prior research 6 has also demonstrated high placebo response rates in gambling disorder treatment. Such results warrant further attention to non-specific factors related to therapy as meaningful for clinical improvement in CSBD.…”

Section: Tolerability and Efficacy Of Paroxetine And Naltrexone For T...mentioning

confidence: 99%

Tolerability and efficacy of paroxetine and naltrexone for treatment of compulsive sexual behaviour disorder

et al. 2022

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“…This is the case for opioid antagonists such as naltrexone, which was tested in patients with compulsive sexual behavior 22 or GbD, 153,154 or nalmefene, which was tested in patients with GbD. 155 Moreover, a transversal approach would permit clinicians to not surcharge for multiple therapies and improve the impact of therapies because of co-occurrences. 41 Indeed, when comparing patients with both an alcohol use disorder and a BA to patients with only an alcohol use disorder, it seems that the presence of the BA is linked with increased craving and impulsivity.…”

Section: Expected Results and Clinical Implicationsmentioning

confidence: 99%

A Case–Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols

Hurel¹,

Grall‐Bronnec²,

Thiabaud³

et al. 2021

NDT

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Introduction: Only two behavioral addictions (BAs) are currently recognized in international classifications (gambling disorder: GbD; gaming disorder: GmD), while some of them await further investigation (food addiction: FA; sexual addiction: SA). Neurocognitive functioning is considered a risk factor for BAs. Research is quite abundant for GbD and highlights specific deficits in several cognitive functions. Nevertheless, grey areas still exist. The aim of this research programme is to investigate the neurocognitive profiles of patients presenting with various BAs and to establish parallels between different forms of BA to achieve a common addiction concept. Methods and Analysis: This research program is composed of two studies sharing the same methodology but focusing on different samples: the BANCO study aims to include 30 individuals with a GbD, whereas the BANCO2 study aims to include 30 individuals with a GmD, 30 with a SA, and 30 with a FA. Moreover, for each BA group, 30 healthy controls will be recruited, matched by sex, age and education level. Several cognitive tasks will be completed by participants. Cue reactivity and physiological responses, as well as clinical data regarding addiction characteristics and personality, will also be investigated. A composite score based on the cognitive tasks will be computed using principal component analysis (PCA). Overall cognitive performance and detailed performance on the different cognitive tasks will be compared between individuals with BAs and their matched healthy controls using linear models with random effects. Comparisons will also be made between BA groups to investigate specific alterations associated with each disorder. Discussion: The results of this research programme will impact both research and clinical areas by (i) providing new knowledge for discussions regarding the inclusion of BAs under the spectrum of addictive disorders; (ii) improving understanding of addiction mechanisms in general; (iii) providing clarity in the grey areas in neurocognitive research on BAs and improving the understanding of less studied BAs, (iv) guiding clinicians to propose therapeutic alternatives and complementary programmes.

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Current pharmacotherapy for gambling disorder: a systematic review

Cited by 39 publications

References 88 publications

Functional connectivity in reward‐related networks is associated with individual differences in gambling strategies in male Lister hooded rats

Functional connectivity in reward‐related networks is associated with individual differences in gambling strategies in male Lister hooded rats

Tolerability and efficacy of paroxetine and naltrexone for treatment of compulsive sexual behaviour disorder

A Case–Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols

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