Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

Abstract

Abstract:: Quinoline derivatives are considered as broad spectrum pharmacological compounds that exhibit wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior. Due to its wide range of pharmaceutical applications it is very popular compound to design new drugs for treatment of multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer’s disease and diabetes . In this review our major focus is to pay attention on biological activities of quinoline compounds in treatment of these diseases such as, anti-viral, anti-cancer, anti-malarial, anti-bacterial, anti-fungal, anti-tubercular and anti-diabetic.

Design, synthesis and evaluation of quinoline- O -carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease

“…Quinoline core ( Figure 1 ), a bicyclic structure in which a pyridinic ring is fused to a benzene moiety, occurs in several natural compounds ( Cinchona alkaloids) and in drugs, with a broad range of biological activities including antimicrobial, antifungal, antitumor, antiviral, anticholesterol and anti-Alzheimer’s disease 15 , 16 . The 8-hydroxy quinoline derivatives clioquinol and PBT2 ( Figure 1 ), promising multifunctional agents, have been investigated for their neuroprotective effect in AD and have entered clinical trials for AD 17 .…”

New transition metal complexes of 1‐phenyl‐2‐((quinolin‐2‐ylmethylene)amino)ethan‐1‐ol Schiff base: Spectroscopic, X‐ray, DFT, Hirshfeld surface analysis, biological, and molecular docking studies

“…Therefore, due to its wide range of pharmaceutical applications, it is urgent to design new compounds containing quinoline moiety to act as potential drugs for the treatment of many diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease, and diabetes. [ 24 ]…”

“…Therefore, due to its wide range of pharmaceutical applications, it is urgent to design new compounds containing quinoline moiety to act as potential drugs for the treatment of many diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease, and diabetes. [24] To continue our investigations to develop novel Schiff base derivatives that can act as potential drugs to cure various diseases, [1][2][3]5] here we report the synthesis of a new Schiff base with a quinoline part, 1-phenyl-2-((quinolin-2-ylmethylene)amino)ethanol (HL; Scheme 1) along with its coordination derivatives of some transition metal ions. The study included the synthesis and analytical and spectroscopic characterization of the Schiff base ligand and its complexes.…”

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

“…Quinoline scaffolds find application in numerous pharmaceutically potent drugs and received much attention in the field of medicinal chemistry. Quinoline scaffolds were reported to show a broad range of biological activities such as antifungal ( Tabassum et al, 2021 ), antibacterial ( Ghosh et al, 2020 ), antileishmanial ( Gupta et al, 2021 ), anticonvulsant ( Al-Ostoot et al, 2021 ), anti-Zaka virus ( Taha et al, 2019 ), antimalarial ( Vinindwa et al, 2021 ), proton pump inhibitors ( Cernicchi et al, 2021 ), antiproliferative ( Ammar et al, 2021 ), antiulcer ( Atukuri et al, 2020 ), antidiabetic ( Taha et al, 2019 ), antimicrobial, anti-inflammatory ( Douadi et al, 2020 ), antitrypanosomal ( Zhang et al, 2018 ), antitubercular ( Nesaragi et al, 2021 ), antioxidant agent ( Velmurugan et al, 2021 ), and antihypertensive ( Kumari et al, 2019 ).…”