Current perspectives on the obesity hypoventilation syndrome

Piper, Amanda J.; Grunstein, Ronald R.

doi:10.1097/mcp.0b013e3282ef6894

Cited by 18 publications

(16 citation statements)

References 54 publications

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“…On the other hand, it should be remarked that all patients included in our study were diagnosed with OSA, and mean AHI value was really high (>50 events/h) in all three groups. This confirms the well known pathophysiological link between OSA and OHS [18–20]. …”

Section: Discussionsupporting

confidence: 88%

Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

Damiani

Falcone

Carratù

et al. 2017

Multidiscip Respir Med

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BackgroundTo date, an important aspect that has still not been clarified is the assessment of OHS severity. The purpose of this retrospective study was to evaluate whether grading OHS severity according to PaCO2 values may be useful in order to provide a more definite characterization and targeted management of patients. In this regard, baseline anthropometric and sleep polygraphic characteristics, treatment options, and follow up outcomes, were compared between OHS patients with different degree of severity (as assessed according to PaCO2 values).MethodsPatients were classified into three groups, according to PaCO2 values: 1) mild (46 mmHg ≤ PaCO2 ≤ 50 mmHg), moderate (51 mmHg ≤ PaCO2 ≤ 55 mmHg), severe (PaCO2 ≥ 56 mmHg). Therefore, differences among the groups in terms of baseline anthropometric, and sleep polygraphic characteristics, treatment modalities and follow up outcomes were retrospectively evaluated.ResultsPatients with more severe degree of hypercapnia were assessed to have increased BMI and bicarbonate levels, worse diurnal and nocturnal hypoxemia, and a more severe impairment in pulmonary mechanics compared to milder OHS. CPAP responders rate significantly decreased from mild to severe OHS. After follow up, daytime sleepiness (as measure by the ESS), PaO2, and PaCO2 significantly improved with PAP therapy in all three groups.Discussion and ConclusionsClassification of OHS severity according to PaCO2 levels may be useful to provide a more defined characterization and, consequently, a more targeted management of OHS patients. Further studies are needed to confirm our findings.

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Section: Discussionsupporting

confidence: 88%

Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

Damiani

Falcone

Carratù

et al. 2017

Multidiscip Respir Med

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“…Despite the fact that major attention has been directed toward the metabolic and cardiovascular consequences of obesity, physicians should always bear in mind that obesity posses also a significant load on the respiratory system, by altering lung mechanics and increasing the work of breathing [9]. The majority of obese individuals is able to maintain normal ventilation during wakefulness despite excessive weight and reduced lung volumes through a compensatory increase in ventilatory drive.…”

Section: Introductionmentioning

confidence: 97%

“…The majority of obese individuals is able to maintain normal ventilation during wakefulness despite excessive weight and reduced lung volumes through a compensatory increase in ventilatory drive. In a small number of patients, failure of this compensatory mechanism results in the development of diurnal respiratory failure [9].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical characteristics of obesity hypoventilation syndrome among individuals reporting sleep-related breathing symptoms in northern Greece

et al. 2010

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“…The changes may exacerbate the problem by depressing arousal from sleep in an individual with abnormal breathing. 7 Obese patients with OHS have higher morbidity and mortality rates than obese individuals without OHS. There is an increased chance of also being diagnosed with congestive heart failure (CHF), angina pectoris, and cor pulmonale.…”

Section: Correlation Between Obesity and Ohsmentioning

confidence: 99%

Obesity Hypoventilation Syndrome: What Is It? How Is It Treated? Is There a Cure?

Aigner

Sikka

Whitfield

2009

Bariatric Nursing and Surgical Patient Care

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The literature is reviewed in order to define and describe obesity hypoventilation syndrome (OHS), including a brief history of the origin of this diagnosis. Comorbidities related to OHS are discussed, including obstructive sleep apnea (OSA), which is found in up to 90% of cases. Treatment is then discussed, including the potential of a cure for OHS with a large weight loss (although this would not cure OSA). Large weight loss can be obtained through lifestyle dietary and exercise changes or through bariatric surgery. Those patients who do not lose large amounts of weight are treated with positive airway pressure.

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Current perspectives on the obesity hypoventilation syndrome

Abstract: Understanding the various mechanisms contributing to development of obesity hypoventilation is important in order to identify new approaches to effective long-term management of this disorder.

Cited by 18 publications

References 54 publications

Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

Prevalence and clinical characteristics of obesity hypoventilation syndrome among individuals reporting sleep-related breathing symptoms in northern Greece

Obesity Hypoventilation Syndrome: What Is It? How Is It Treated? Is There a Cure?

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