Current Perspectives on the Development and Treatment of Chronic Daily Headache in Children and Adolescents

Connelly, Mark; Sekhon, Subhjit

doi:10.2217/pmt-2018-0057

Cited by 10 publications

(11 citation statements)

References 80 publications

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“…Therefore, for example, near work such as screen watching will induce more symptoms in children who need glasses compared to children with normal vision 10,[20][21][22][23][24][25][26][27][28] . Headaches and musculoskeletal symptoms in children have been shown to be associated with psychosocial stress and socioeconomic aspects 31,39 . However, these issues were not investigated in our study, and therefore the prevalence and possible effects on symptoms remain unknown.…”

Section: Discussionmentioning

confidence: 99%

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Headache and musculoskeletal pain in school children are associated with uncorrected vision problems and need for glasses: a case–control study

Thorud

Aurjord

Falkenberg

2021

Sci Rep

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Musculoskeletal pain and headache are leading causes of years lived with disability, and an escalating problem in school children. Children spend increasingly more time reading and using digital screens, and increased near tasks intensify the workload on the precise coordination of the visual and head-stabilizing systems. Even minor vision problems can provoke headache and neck- and shoulder (pericranial) pain. This study investigated the association between headaches, pericranial tenderness, vision problems, and the need for glasses in children. An eye and physical examination was performed in twenty 10–15 year old children presenting to the school health nurse with headache and pericranial pain (pain group), and twenty age-and-gender matched classmates (control group). The results showed that twice as many children in the pain group had uncorrected vision and needed glasses. Most children were hyperopic, and glasses were recommended mainly for near work. Headache and pericranial tenderness were significantly correlated to reduced binocular vision, reduced distance vision, and the need for new glasses. That uncorrected vision problems are related to upper body musculoskeletal symptoms and headache, indicate that all children with these symptoms should have a full eye examination to promote health and academic performance.

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Section: Discussionmentioning

confidence: 99%

“…Headache frequency in children and adolescents seems to increase with the transition to adolescence (girls) and in relation to psychosocial stress and obesity 31 , 32 . Tension-type headache is the most prevalent headache in the general population and has a lifetime prevalence between 30 and 78% and a high socioeconomic impact 25 , 33 .…”

Section: Introductionmentioning

confidence: 99%

Headache and musculoskeletal pain in school children are associated with uncorrected vision problems and need for glasses: a case–control study

Thorud

Aurjord

Falkenberg

2021

Sci Rep

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“…Migraine headache in children and adolescents aged under 18 years is more often bilateral rather than the more typical unilateral pain seen in adults, which emerges in late adolescence or early adult life [3]. Prevalence varies amongst the current literature, however, it appears to occur in approximately 2%-6% of children [4][5][6][7][8]. According to one paper, there was a 3% prevalence in younger, school-age children, in line within the prevalence rate range described above; however, this shot up to 20% in older adolescents [9].…”

Section: Introductionmentioning

confidence: 99%

“…Current literature regarding pediatric headaches uses terminology such as chronic migraine and chronic daily headache, including both terms in the few retrospective studies analyzing onabotulinum toxin use in pediatric patients [5][6][11][12][13]. For the purpose of clarity, chronic migraine and chronic tension type headaches are the most frequent subtypes of chronic daily headache, which itself may be primary or secondary, and, overall, headache disorders are very difficult to treat [4,14].…”

Section: Introductionmentioning

confidence: 99%

Further Evidence that Onabotulinum Toxin is a Viable Treatment Option for Pediatric Chronic Migraine Patients

Ali¹,

Bragin²,

Rende³

et al. 2019

Cureus

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Introduction Chronic migraine is particularly devastating. It affects school work, extracurricular activities, and quality of life, including relationships with other family members, and can also influence the mental health of both the migraineurs and family members. According to the International Classification of Headache Disorders, 3rd edition (ICHD-3), chronic migraine is defined as 15 or more headache days per month for greater than three months, where at least on eight days per month, there are features of migraine headache. Although botulinum toxin type A (BoNTA) has been proven effective for treating chronic migraine in adults, little literature exists about its use in children. Here, we present the treatment response in children with chronic migraines treated with BoNTA at our institutions Duke and State University of New York (SUNY) Upstate. Method A retrospective analysis of 30 adolescent migraineurs who met ICHD-3 criteria for chronic migraine were treated with BoNTA injection according to the standardized adult protocol. Descriptive statistics and paired t-tests were performed. A total of 185 units of botulinum toxin were injected intramuscularly per patient, as in addition to the standard 31 sites for a total of 155 units, an additional 30 units were given in areas that were felt to provide further benefit. Results Participants (n=30) were 16.5 ± 1.83 years old. The headaches were precipitated by trauma in seven cases. All had failed standard pharmacotherapy, including amitriptyline and topiramate. An average of 2.47 ± 1.6 BoNTA injection cycles was performed. Migraine severity decreased significantly from 7.47 ± 1.89 on a 10-point scale to 4.34 ± 3.02 (p<.001). Additionally, headache frequency improved from 24.4 ± 7.49 painful days per month to 14.8 ± 12.52 painful days per month (p<.001). One patient developed nausea related to injections; all others tolerated it well, with no side effects. Discussion BoNTA injection was a safe and effective therapy for chronic migraine in our cohort of children recalcitrant to medical therapy. Further research with multi-centered, double-blinded, randomized, placebo-controlled trials is warranted to evaluate the long-term safety and efficacy in this population.

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“…Opioids are often prescribed more than any other non-steroidal anti-inflammatory drugs as a primary level of therapy for headache [5]. Prolonged use of an opioid in patients with headache disorders, such as migraine, carries a high risk of medication overuse headache.…”

Section: Introductionmentioning

confidence: 99%

The Opioid Epidemic and Primary Headache Disorders: A Nationwide Population-Based Study

Patel

Malik

Shah

et al. 2020

Cureus

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The opioid epidemic has been linked to several other health problems, but its impact on headache disorders has not been well studied. We performed a population-based study looking at the prevalence of opioid use in headache disorders and its impact on outcomes compared to non-abusers with headaches. Methodology We performed a cross-sectional analysis of the Nationwide Inpatient Sample (years 2008-2014) in adults hospitalized for primary headache disorders (migraine, tension-type headache [TTH], and cluster headache [CH]) using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. We performed weighted analyses using the chi-square test, Student's t-test, and Cochran-Armitage trend test. Multivariate survey logistic regression analysis with weighted algorithm modelling was performed to evaluate morbidity, disability, and discharge disposition. Among US hospitalizations during 2013-2014, regression analysis was performed to evaluate the odds of having opioid abuse among headache disorders. Results A total of 5,627,936 headache hospitalizations were present between 2008 and 2014 of which 3,098,542 (55.06%), 113,332 (2.01%), 26,572 (0.47%) were related to migraine, TTH, and CH, respectively. Of these headache hospitalizations, 128,383 (2.28%) patients had abused opioids. There was a significant increase in the prevalence trend of opioid abuse among patients with headache disorders from 2008 to 2014. The prevalence of migraine (63.54% vs. 54.86%), TTH (2.29% vs. 2.01%), and CH (0.59% vs. 0.47%) was also higher among opioid abusers than nonabusers (p<0.0001). Opioid abusers with headaches were more likely to be younger (43 years old vs. 50 years old), men (30.17% vs. 24.78%), white (80.83% vs. 73.29%), Medicaid recipients (30.15% vs. 17.03%), and emergency admissions (85.4% vs. 78.51%) as compared to opioid nonabusers with headaches (p<0.0001). Opioid abusers with headaches had higher prevalence and odds of morbidity (4.06% vs. 3.70%; adjusted odds ratio [aOR]: 1.48; 95% CI:

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Current Perspectives on the Development and Treatment of Chronic Daily Headache in Children and Adolescents

Cited by 10 publications

References 80 publications

Headache and musculoskeletal pain in school children are associated with uncorrected vision problems and need for glasses: a case–control study

Headache and musculoskeletal pain in school children are associated with uncorrected vision problems and need for glasses: a case–control study

Further Evidence that Onabotulinum Toxin is a Viable Treatment Option for Pediatric Chronic Migraine Patients

The Opioid Epidemic and Primary Headache Disorders: A Nationwide Population-Based Study

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