Current Perspectives on Oxycodone/Naloxone Prolonged Release for Managing Severe Cancer Pain: A Comprehensive Update of Literature
Paolo Formenti,
Michele Umbrello,
Mauro Pignataro
et al.
Abstract:Severe cancer pain significantly diminishes patients' quality of life, leading to increased reliance on caregivers. Although opioid analgesics are effective, they may induce opioid-induced bowel dysfunction (OIBD) with symptoms such as nausea, vomiting, drowsiness, and constipation. While controlled-release oxycodone is a viable option, its prolonged use can lead to opi-oid-induced constipation (OIC). Addressing this, a relative novel formulation - a fixed 2:1 ratio of oxycodone and naloxone in prolon… Show more
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