Current perspectives of biodegradable drug-eluting stents for improved safety

Kim, Soon-Joong; Kim, Tae-Hyung; Choi, Jung-Hwa; Kwon, Il Keun

doi:10.1007/s12257-011-0571-z

Cited by 7 publications

(6 citation statements)

References 67 publications

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“…Synthesized polymers used in DES and orthopaedic implants can be permanent or biodegradable. Permanent polymers can allow controlled drug release and remain after the drug is completely released [ 95 , 96 ]. Polymer properties affecting DES performance are summarized in Fig.…”

Section: Polymer Coatingsmentioning

confidence: 99%

“…Composite coatings produced by the sol–gel process showed a higher compatibility than coatings produced by MAO [ 130 ]. In DES, drugs of the “limus” family [ 57 , 95 , 99 , 131 ] and paclitaxel [ 95 , 132 , 133 ] can help inhibit smooth muscle cell proliferation. Another approach to improve the in vivo performance of stents is to promote endothelialization.…”

Section: Coatings and Biocompatibilitymentioning

confidence: 99%

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Similarities and differences in coatings for magnesium-based stents and orthopaedic implants

Thompson

Zhao

et al. 2014

Journal of Orthopaedic Translation

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Magnesium (Mg)-based biodegradable materials are promising candidates for the new generation of implantable medical devices, particularly cardiovascular stents and orthopaedic implants. Mg-based cardiovascular stents represent the most innovative stent technology to date. However, these products still do not fully meet clinical requirements with regards to fast degradation rates, late restenosis, and thrombosis. Thus various surface coatings have been introduced to protect Mg-based stents from rapid corrosion and to improve biocompatibility. Similarly, different coatings have been used for orthopaedic implants, e.g., plates and pins for bone fracture fixation or as an interference screw for tendon-bone or ligament-bone insertion, to improve biocompatibility and corrosion resistance. Metal coatings, nanoporous inorganic coatings and permanent polymers have been proved to enhance corrosion resistance; however, inflammation and foreign body reactions have also been reported. By contrast, biodegradable polymers are more biocompatible in general and are favoured over permanent materials. Drugs are also loaded with biodegradable polymers to improve their performance. The key similarities and differences in coatings for Mg-based stents and orthopaedic implants are summarized.

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Section: Polymer Coatingsmentioning

confidence: 99%

Section: Coatings and Biocompatibilitymentioning

confidence: 99%

Similarities and differences in coatings for magnesium-based stents and orthopaedic implants

Thompson

Zhao

et al. 2014

Journal of Orthopaedic Translation

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“…Various biodegradable and biocompatible polymers such PLA, PCL and PLGA have been used in different fields of biomedical application for several decades [11]. Thus, to address the limitation related to permanent polymer coatings, different biodegradable polymeric coatings with various drug delivery strategies and stent design have been introduced [12][13][14]. Temporary stent scaffold is a new concept in stent technology which has attracted lots of researcher's attention.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of different polymeric coatings for the next-generation magnesium-based biodegradable stents

Lakalayeh

Rahvar

Haririan

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility. Potentiodynamic and electrochemical impedance spectroscopy results demonstrated that PLA and PLGA coating performed better in improving corrosion resistance in comparison with uncoated and other coated samples. Although all coated and bare samples displayed desirable results of haemocompatibility assays, PLA-coated samples showed better outcome in terms of biocompatibility. The results revealed that PLA can be considered as a potential coating material to enhance the main characteristics of magnesium-based bioabsorbable stents.

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“…Drug eluting stents (DES) treat atherosclerosis by structurally opening diseased arteries and releasing an anti‐inflammatory drug from the polymer coating, thereby mitigating the extent of in‐stent restenosis . The new generation of DES either has a completely biodegradable platform or is coated with a biodegradable polymer on a conventional bare metal stent . The incorporation of absorbable polymers like poly(lactic‐ co ‐glycolic acid) (PLGA) not only enable more rapid and complete drug delivery, but also reduce the risk of complications associated with permanent polymeric components of implantable devices, such as the late and very late stent thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Mapping intermediate degradation products of poly(lactic‐co‐glycolic acid) in vitro

Nemes

Guo

2017

J Biomed Mater Res

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There is widespread interest in using absorbable polymers, such as poly(lactic-co-glycolic acid) (PLGA), as components in the design and manufacture of new-generation drug eluting stents (DES). PLGA undergoes hydrolysis to progressively degrade through intermediate chemical entities to simple organic acids that are ultimately absorbed by the human body. Understanding the composition and structure of these intermediate degradation products is critical not only to elucidate polymer degradation pathways accurately, but also to assess the safety and performance of absorbable cardiovascular implants. However, analytical approaches to determining the intermediate degradation products have yet to be established and evaluated in a standard or regulatory setting. Hence, we developed a methodology using electrospray ionization mass spectrometry to qualitatively and quantitatively describe intermediate degradation products generated in vitro from two PLGA formulations commonly used in DES. Furthermore, we assessed the temporal evolution of these degradation products using time-lapse experiments. Our data demonstrated that PLGA degradation products via heterogeneous cleavage of ester bonds are modulated by multiple intrinsic and environmental factors, including polymer chemical composition, degradants solubility in water, and polymer synthesis process. We anticipate the methodologies and outcomes presented in this work will elevate the mechanistic understanding of comprehensive degradation profiles of absorbable polymeric devices, and facilitate the design and regulation of cardiovascular implants by supporting the assessments of the associated biological response to degradation products. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1129-1137, 2018.

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Current perspectives of biodegradable drug-eluting stents for improved safety

Cited by 7 publications

References 67 publications

Similarities and differences in coatings for magnesium-based stents and orthopaedic implants

Similarities and differences in coatings for magnesium-based stents and orthopaedic implants

Comparative study of different polymeric coatings for the next-generation magnesium-based biodegradable stents

Mapping intermediate degradation products of poly(lactic‐co‐glycolic acid) in vitro

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