Current Perspectives in Kidney Diseases

Ronco, Claudio; Manna, Gaetano La

doi:10.1159/000484127

Cited by 3 publications

(3 citation statements)

References 22 publications

(22 reference statements)

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“…The MWCO of the PSF/SM blended hollow fiber membranes was 14.4 kDa (H‐1), 16.3 kDa (H‐2), and 24.1 kDa (H‐3), respectively. The membranes were mainly used during hemodialysis to remove small molecular weight toxins (urea, 60 Da), medium molecular weight toxins (β2‐microglobulin, 12 kDa), and to prevent albumin(68 kDa) loss 32 . The MWCO of the blended hollow fiber membranes was all between medium molecular toxins and albumin.…”

Section: Resultsmentioning

confidence: 99%

“…The membranes were mainly used during hemodialysis to remove small molecular weight toxins (urea, 60 Da), medium molecular weight toxins (β2-microglobulin, 12 kDa), and to prevent albumin(68 kDa) loss. 32 The MWCO of the blended hollow fiber membranes was all between medium molecular toxins and albumin. The toxins could be eliminated and albumin could be retained by these membranes.…”

Section: Surface Morphology Molecular Weight Cutoffs (Mwco) and Porositymentioning

confidence: 99%

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Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti‐M1 macrophage polarization and hemocompatibility for blood purification

et al. 2023

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Oxidative stress is highly prevalent in maintenance hemodialysis patients and increases the risk of cardiovascular morbidity and mortality. Silymarin (SM) is a natural compound extracted from plants, and has been shown to have pharmacological effects such as antioxidant, anti‐inflammatory, cytoprotective, and anti‐nephrotoxicity. SM‐modified polysulfone (PSF) hemodialysis membranes were prepared by an immersion‐precipitation phase transition method. The experimental results showed that the modified membranes effectively scavenged free radicals, significantly inhibited lipid peroxidation, and had good antioxidant stability (60 days). The PSF/SM antioxidant membranes (H‐3) had no pro‐inflammatory effect, which was confirmed by the result of anti‐M1 macrophage polarization. Furthermore, the hemolysis rate (2%), blood cell deformation (3.7%), and inhibition of erythrocyte and platelet adhesion were improved by the SM‐modified PSF membranes. All the results suggest that PSF/SM blended hollow fiber membranes are promising for application in hemodialysis membranes to improve oxidative stress status and reduce inflammation and complications in patients.

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Section: Resultsmentioning

confidence: 99%

Section: Surface Morphology Molecular Weight Cutoffs (Mwco) and Porositymentioning

confidence: 99%

Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti‐M1 macrophage polarization and hemocompatibility for blood purification

et al. 2023

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show abstract

“…[3,4] As such, new and more effective techniques are needed. [5] The development of new biomaterials and the utilization of new mechanisms of blood purification such as adsorption are new areas of intense research. [6] Studies on the application of hemoadsorption (HA) however, have produced controversial results or a level of evidence that is often considered insufficient to recommend the use of these techniques in routine medical practice.…”

Section: Introductionmentioning

confidence: 99%