Current patient perceptions on the menopause: a South African perspective

Smith, A. J.; Hall, David; Grové, D.

doi:10.1080/13697130500196817

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…A study in a private gynaecology practice in the Western Cape from the early 2000s noted that 78.5% of surveyed postmenopausal patients were using hormonal therapy, and that 42% had been using it for longer than 10 years. 27 The role that CHRT plays in the development of ILC in private patients in South Africa needs to be investigated.…”

Section: Discussionmentioning

confidence: 99%

A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital

et al. 2022

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BACKGROUND: The second most common histological subtype of invasive breast carcinoma is invasive lobular carcinoma (ILC) occuring with a frequency 10-15% in Western countries and approximately 5%, in Africa, the Middle East and Asia (AMA). Combined hormone replacement therapy (CHRT) is a risk factor for the development of ILC which is infrequently diagnosed at our centre.This study aimed to investigate the incidence and clinicopathological characteristics of ILC as compared to invasive breast carcinoma of no special type (IBC-NST METHODS: Clinical and pathological data on breast carcinoma patients attending the breast and endocrine unit at Tygerberg Academic Hospital since 2017 have been recorded on a Stellenbosch University REDCap® database RESULTS: IBC-NST was the most frequent subtype diagnosed (83.9%) and ILC the second most common subtype (5.2%). Most ILCs were of luminal B intrinsic subtype, and the median size was slightly smaller than IBC-NST. There were significantly more grade 2 ILCs than IBC-NSTs (81.5% vs 50.9%). There was no statistical difference between stage and histological subtype CONCLUSION: ILC has clinicopathological differences when compared to IBC-NST, although these were less pronounced in this study. The prevalence of ILC was similar to numbers reported in AMA. We hypothesise that there may be a discrepancy in the prevalence of ILC between public and private healthcare systems in South Africa, and that it may be due to differing trends in prescribing CHRT

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Section: Discussionmentioning

confidence: 99%

A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital

et al. 2022

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“…Premenopausal status was defined as younger than 50 years of age with postmenopausal status described as 50 years or older. 7 The clinicopathological features of tumour size, nodal status, and distant metastases in accordance with tumour-node-metastasis (TNM) staging, tumour grade, Ki67 values and histological subtype were recorded. 8 Data was collected from the authorised reports and captured on an Excel datasheet.…”

Section: Methodsmentioning

confidence: 99%

Triple-negative breast cancer - a retrospective audit of 151 cases seen at the Charlotte Maxeke Johannesburg Academic Hospital Breast Unit

2022

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BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive, rapidly lethal subgroup of breast cancer which disproportionately affects women of African descent. Lacking hormone receptor expression and human epidermal growth factor receptor 2 (HER2) overexpression, it is difficult to treat. Despite an initial good response to chemotherapy, relapse is common and survival short. The aim of this study of treatment-naive women with TNBC was examination of clinicopathological characteristics and any association of these with patient demographics. METHODS: Demographic data was captured together with the clinical, pathological and histological features of the cancers. Statistical analysis was performed. RESULTS: Of the 960 patients entered in the database of the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) Breast Unit (BU) over a 3-year period, 151 (15.7%) had TNBC. All patients were female aged 25 to 98 years, and 60.3% were postmenopausal (mean age 64 years). The majority (80.2%) self-identified as black African. Most patients had clinical stage 3 disease, and 17.2% had distant metastases. One hundred women were HIV negative, 35 positive and 20 untested. Tumour biology revealed high-grade morphology in 70% of cases with a mean Ki-67 value of 60%. Forty patients died within 18 months of entry in the database. CONCLUSION: In this series, most patients with TNBC were older, postmenopausal women. This patient cohort may represent a non-basal subtype of TNBC but gene expression profiling was not available. Tumours were locally advanced, rapidly proliferative but not associated with HIV status. The short survival times emphasise the importance of neoadjuvant chemotherapy as soon as the diagnosis of TNBC is made.

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“…The QoL study was conducted as part of another study in which patient perceptions and perspectives on the menopause were evaluated [9]. A questionnaire, utilising the validated Utian QoL (UQoL) scale, was posted to all eligible patients [10].…”

Section: Methodsmentioning

confidence: 99%

Postmenopausal hormone therapy and quality of life

Smith¹,

Hall²,

Grové³

2006

Intl J Gynecology & Obste

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Current patient perceptions on the menopause: a South African perspective

Abstract: This group of women was well informed regarding current indications and developments concerning HT. Despite their socioeconomic status, the doctor remained the key factor with regard to information and decision-making.

Cited by 7 publications

References 17 publications

A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital

A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital

Triple-negative breast cancer - a retrospective audit of 151 cases seen at the Charlotte Maxeke Johannesburg Academic Hospital Breast Unit

Postmenopausal hormone therapy and quality of life

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