Current Options in the Diagnosis and Treatment of Monkeypox

Torres, Heidi M

doi:10.1007/s12281-022-00448-8

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…14 The 2022 MPXV outbreak prompted the development of several assays to aid in diagnosis, disease control, and monitoring. 15,16 The RUO MPXV Assay was developed as a blood donation screening assay to be used as a research tool and potentially as needed in response to the outbreak. With the rapid spread of mpox and the uncertainty regarding transfusion transmission early in the outbreak, a potential risk of MPXV to the blood supply could not be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…Due to continuous threats posed by emerging/re‐emerging infectious diseases, strategies to maintain the availability and safety of the blood supply have been evolving, mainly through enhanced donor screening and testing 14 . The 2022 MPXV outbreak prompted the development of several assays to aid in diagnosis, disease control, and monitoring 15,16 . The RUO MPXV Assay was developed as a blood donation screening assay to be used as a research tool and potentially as needed in response to the outbreak.…”

Section: Discussionmentioning

confidence: 99%

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Nucleic acid testing for monkeypox in United States blood donor specimens

et al. 2023

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BackgroundThe 2022 multi‐country outbreak of monkeypox (mpox) resulted in blood collection and public health agencies closely monitoring for changes in transmission dynamics that could pose a threat to the blood supply. While mpox virus (MPXV) is not known to be transfusion transmissible, there have been several studies demonstrating the detection of MPXV in blood. We evaluated the performance characteristics of a research use only (RUO) nucleic acid amplification test for MPXV. The assay was developed to detect MPXV DNA in plasma and serum specimens from human blood donors.Methods and MaterialsThe sensitivity of the RUO MPXV Assay was determined using a synthetic DNA sequence, purified full‐length genomic DNA, and a chemically inactivated virus. Specificity was determined using fresh plasma samples collected from blood donors during the outbreak. Plasma samples collected from donors considered at increased risk for exposure to mpox were also tested.ResultsFor sensitivity, the 95% limit of detection (LOD) ranged from 0.26 copies/mL (inactivated virus) to 31.65 copies/mL (synthetic DNA) to 166.61 copies/mL (for full‐length DNA). All donor samples tested with the RUO MPXV Assay were nonreactive, resulting in a specificity of 100% (95% CI, 99.93%–100.00%).DiscussionThe RUO MPXV Assay was developed as a potential blood donation screening assay in response to the outbreak. While not directly comparable, the 95% LOD fiducial limits obtained from partial‐ and full‐length DNA analysis were similar to other manufacturers' MPXV assays. Additionally, this assay demonstrated high specificity for screening blood donors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nucleic acid testing for monkeypox in United States blood donor specimens

et al. 2023

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“…However, given that mpox virus disease is a rapidly evolving field, we regularly find new original research articles cropping up. We found several original research articles reporting on treatment options and other aspects of mpox virus disease that were not discussed in previous review articles (DeLaurentis et al, 2022;McCarthy, 2022;Torres, 2022;Rabaan et al, 2023;Shamim et al, 2023). This paper gives a brief analysis of literature from the past till the current time about the pharmacological treatment of the disease and the drugs being administered along with the vaccines being used.…”

Section: Introductionmentioning

confidence: 99%

Re-emergence of neglected tropical diseases amid the COVID-19 pandemic: Epidemiology, transmission, mitigation strategies, and recent advances in chemotherapy and vaccines

K. Mohapatra,

Seidel,

Kandi

et al. 2023

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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