Current Opinions in Chrononutrition and Health

Bravo, Rafael; Uguz, C; Cubero, Javier Segovia

doi:10.4172/2472-1921.100040

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Recognition of the impact of lifestyle behaviors on circadian dysregulation and metabolic and reproductive function, opens the way for targeted intervention strategies to modulate and reverse these effects [246]. These include regular meal timing [222,247], time-restricted feeding [248,249], restoration of normal sleep cycles [250], optimal exercise timing [235], limitation of exposure to bright light at night [251], and improved diet quality [227].…”

Section: Circadian Rhythm Disruption and Pcosmentioning

confidence: 99%

Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment

Parker

O’Brien

Hawrelak

et al. 2022

IJERPH

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Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic disorder that manifests in genetically susceptible women following a range of negative exposures to nutritional and environmental factors related to contemporary lifestyle. The hypothesis that PCOS phenotypes are derived from a mismatch between ancient genetic survival mechanisms and modern lifestyle practices is supported by a diversity of research findings. The proposed evolutionary model of the pathogenesis of PCOS incorporates evidence related to evolutionary theory, genetic studies, in utero developmental epigenetic programming, transgenerational inheritance, metabolic features including insulin resistance, obesity and the apparent paradox of lean phenotypes, reproductive effects and subfertility, the impact of the microbiome and dysbiosis, endocrine-disrupting chemical exposure, and the influence of lifestyle factors such as poor-quality diet and physical inactivity. Based on these premises, the diverse lines of research are synthesized into a composite evolutionary model of the pathogenesis of PCOS. It is hoped that this model will assist clinicians and patients to understand the importance of lifestyle interventions in the prevention and management of PCOS and provide a conceptual framework for future research. It is appreciated that this theory represents a synthesis of the current evidence and that it is expected to evolve and change over time.

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