Current Natural Bioactive Materials in Bone and Tooth Regeneration in dentistry: A Comprehensive Overview

Moghadam, Ehsan Tafazoli; Yazdanian, Mohsen; Alam, Mostafa; Tebyanian, Hamid; Tafazoli, Ali; Tahmasebi, Elahe; Ranjbar, Reza; Yazdanian, Alireza; Seifalian, Alexander M.

doi:10.1016/j.jmrt.2021.05.089

Cited by 45 publications

(16 citation statements)

References 300 publications

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“…Nanomaterials are used as either antimicrobials for their inherent antimicrobial properties or drug delivery systems specifically designed to have affinity to dental surfaces [ 31 ]. Silver (Ag), copper oxide (CuO, Cu 2 O, Cu 2 O 3 , and CuO 2 ), zinc oxide (ZnO), titanium oxide (TiO, TiO 2 , and Ti 2 O 3 ), graphene (an allotrope of carbon), quaternary ammonium polyethyleneimine (QA-PEI), chitosan (CH), and silica (SiO 2 ) nanoparticles are examples of numerous nanomaterials that can control biofilm formation [ 29 , 32 – 36 ]. Among all, silver nitrate (AgNO 3 ) and silver nanoparticles (AgNPs) are indicated as specific metal nanomaterials with one of the highest capacities to control the oral biofilm [ 37 ].…”

Section: Chemical Antibiofilm Materialsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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Herbal and chemical products are used for oral care and biofilm treatment and also have been reported to be controversial in the massive trials conducted in this regard. The present review is aimed at evaluating the potential of relevant herbal and chemical products and comparing their outcomes to conventional oral care products and summarizing the current state of evidence of the antibiofilm properties of different products by evaluating studies from the past eleven years. Chlorhexidine gluconate (CHX), essential oils (EOs), and acetylpyridinium chloride were, respectively, the most commonly studied agents in the included studies. As confirmed by all systematic reviews, CHX and EO significantly control the plaque formation and gingival indices. Fluoride is another interesting reagent in oral care products that has shown promising results of oral health improvement, but the evidence quality needs to be refined. The synergy between natural plants and chemical products should be targeted in the future to accede to the formation of new, efficient, and healthy anticaries strategies. Moreover, to discover their biofilm-interfering or biofilm-inhibiting activities, effective clinical trials are needed. In this review article, therapeutic applications of herbal/chemical materials in oral biofilm infections are discussed in recent years (2010-2022).

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Section: Chemical Antibiofilm Materialsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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“…Other reports had also been made stating that CA increases phosphorylated protein kinase B and cyclin D1 production which led to increased stem cell proliferation and osteogenesis [ 56 ]. CA has also been used for decades in traditional Chinese medicine, especially for osteoporosis, due to its anti-inflammatory and osteogenesis capability [ 57 ]. In the commercial world, biomedical companies and scientists alike are attempting to fabricate an improved version of MTA for clinical application.…”

Section: Resultsmentioning

confidence: 99%

Additive Manufacturing of Caffeic Acid-Inspired Mineral Trioxide Aggregate/Poly-ε-Caprolactone Scaffold for Regulating Vascular Induction and Osteogenic Regeneration of Dental Pulp Stem Cells

Tien

Lee

et al. 2021

Cells

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Mineral trioxide aggregate (MTA) is a common biomaterial used in endodontics regeneration due to its antibacterial properties, good biocompatibility and high bioactivity. Surface modification technology allows us to endow biomaterials with the necessary biological targets for activation of specific downstream functions such as promoting angiogenesis and osteogenesis. In this study, we used caffeic acid (CA)-coated MTA/polycaprolactone (PCL) composites and fabricated 3D scaffolds to evaluate the influence on the physicochemical and biological aspects of CA-coated MTA scaffolds. As seen from the results, modification of CA does not change the original structural characteristics of MTA, thus allowing us to retain the properties of MTA. CA-coated MTA scaffolds were shown to have 25% to 55% higher results than bare scaffold. In addition, CA-coated MTA scaffolds were able to significantly adsorb more vascular endothelial growth factors (p < 0.05) secreted from human dental pulp stem cells (hDPSCs). More importantly, CA-coated MTA scaffolds not only promoted the adhesion and proliferation behaviors of hDPSCs, but also enhanced angiogenesis and osteogenesis. Finally, CA-coated MTA scaffolds led to enhanced subsequent in vivo bone regeneration of the femur of rabbits, which was confirmed using micro-computed tomography and histological staining. Taken together, CA can be used as a potently functional bioactive coating for various scaffolds in bone tissue engineering and other biomedical applications in the future.

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“…The main effects are the inhibition of bone resorption and the enhancement of bone formation and maturation [ 136 ]. Different flavonoids (polyphenols obtained from plants) prevent bone resorption processes while promoting osteoblastogenesis [ 137 ] (facilitating differentiation of mesenchymal cells (MSCs) into osteoblasts). The most representative examples are (a) epigallocatechin-3-gallate, obtained from the plant Camellia sinensis , which shows a great capacity to induce cell proliferation, osteogenesis, and mineralization [ 138 ], together with anti-inflammatory, antibacterial, and antioxidant functionalities [ 139 , 140 ]; (b) acemannan, obtained from plant Aloe vera , has a well-demonstrated capacity to increase both cell proliferation and bone healing rate, and lead to a fast bone and ligament regeneration [ 141 , 142 ]; (c) icariin, an active agent obtained from Herba Epimediian , which promotes osteoinductivity (e.g., Alg/HAp [ 143 ] and PLGA/β-calcium phosphate [ 144 ] systems); (d) curcumin, the main component of plant Curcuma longa , is a well-known agent for the treatment of different pathologies due to antibacterial, antioxidant, and healing properties [ 145 ] which enhance cell differentiation, proliferation, and migration and also has beneficial effects in the treatment of diabetes [ 146 ] and osteosarcoma patients [ 147 ]; and (e) revesratrol, a component of fruits such as grapes, berries, and nuts, which improves the blood supply to bones [ 148 ], facilitates the expression of endothelial growth factors and the osteogenic differentiation, has beneficial effects decreasing tumorigenicity against cancer cells [ 149 ], and shows a high potential for bone and cartilage regeneration [ 150 , 151 ].…”

Section: Multifunctional Scaffoldsmentioning

confidence: 99%

Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration

Kadkhodaie-Elyaderani

Lama-Odría

Valle

et al. 2022

IJMS

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Tissue engineering is nowadays a powerful tool to restore damaged tissues and recover their normal functionality. Advantages over other current methods are well established, although a continuous evolution is still necessary to improve the final performance and the range of applications. Trends are nowadays focused on the development of multifunctional scaffolds with hierarchical structures and the capability to render a sustained delivery of bioactive molecules under an appropriate stimulus. Nanocomposites incorporating hydroxyapatite nanoparticles (HAp NPs) have a predominant role in bone tissue regeneration due to their high capacity to enhance osteoinduction, osteoconduction, and osteointegration, as well as their encapsulation efficiency and protection capability of bioactive agents. Selection of appropriated polymeric matrices is fundamental and consequently great efforts have been invested to increase the range of properties of available materials through copolymerization, blending, or combining structures constituted by different materials. Scaffolds can be obtained from different processes that differ in characteristics, such as texture or porosity. Probably, electrospinning has the greater relevance, since the obtained nanofiber membranes have a great similarity with the extracellular matrix and, in addition, they can easily incorporate functional and bioactive compounds. Coaxial and emulsion electrospinning processes appear ideal to generate complex systems able to incorporate highly different agents. The present review is mainly focused on the recent works performed with Hap-loaded scaffolds having at least one structural layer composed of core/shell nanofibers.

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Current Natural Bioactive Materials in Bone and Tooth Regeneration in dentistry: A Comprehensive Overview

Cited by 45 publications

References 300 publications

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Additive Manufacturing of Caffeic Acid-Inspired Mineral Trioxide Aggregate/Poly-ε-Caprolactone Scaffold for Regulating Vascular Induction and Osteogenic Regeneration of Dental Pulp Stem Cells

Multifunctional Scaffolds Based on Emulsion and Coaxial Electrospinning Incorporation of Hydroxyapatite for Bone Tissue Regeneration

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