Current Methods of Prevention of Aminoglycoside Ototoxicity in Patients with Pulmonary Tuberculosis

Solokha, A. A.; Stavitskaya, N. V.; Shvаrts, Ya. Sh.; Sklyuev, Sergey; Турсунова, Н. В.

doi:10.58838/2075-1230-2023-101-3-87-93

Tuberk. bolezni lëgk.

2023

DOI: 10.58838/2075-1230-2023-101-3-87-93

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Current Methods of Prevention of Aminoglycoside Ototoxicity in Patients with Pulmonary Tuberculosis

A. A. Solokha

N. V. Stavitskaya

Ya. Sh. Shvаrts

et al.

Abstract: Contemporary publications on possible pharmaceutical treatment of ototoxic effect of aminoglycosides have been analyzed. In this respect, substances with the antioxidant effect seem to be the most promising. Their use in therapeutic doses is not accompanied by adverse reactions, and they do not interfere with the antibacterial effect of anti-tuberculosis drugs. Currently, the mechanisms of the otoprotective action of various antioxidants are being studied.

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Otoprotective and antioxidant activity of cytoflavin in pulmonary tuberculosis patients receiving amikacin

Solokha,

Tursunova,

Stavitskaya

et al. 2023

Tuberk. bolezni lëgk.

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The objective: to study the potential otoprotective and antioxidant activity of cytoflavin in new pulmonary tuberculosis patients receiving aminoglycoside amikacin.Subjects and Methods. A randomized controlled trial was conducted and included 90 patients with new infiltrative pulmonary tuberculosis with decay, of both genders aged from 20 to 50 years old. Clinical, paraclinical and statistical methods were used in the study. Audiometric screening was carried out by Diagnostic Audiometer AD 226. The degree of antioxidant protection was determined by the oxidation reaction of ABTS in blood serum and plasma.Results. The study included 4 groups of tuberculosis patients and 1 group of healthy donors. Dissemination of pulmonary tuberculosis in 4 groups was approximately the same and was measured by scores. Prior to the start of treatment in all 4 groups (the group receiving standard chemotherapy (CTX) without amikacin, the group receiving «CTX+amikacin», the group receiving «CTX+cytofl avin», the group receiving «CTX+amikacin+cytofl avin») there was a decrease in blood antioxidant activity compared to Control Group. After 3 months of tuberculosis treatment in all 4 groups, the results improved, while in «CTX+Cytofl avin» Group they were similar to Control Group, and «CTX+Amikacin+Cytofl avin Group», they were only 4.8% less. The elevated level of leukocytes decreased by 10.6% in CTX Group, 16.9% in «CTX+Amikacin» Group, 38.3% in «CTX+Cytofl avin» Group, and 72.3% in «CTX+Amikacin+Cytofl avin» Group. In the study, manifestations of oto- and vestibulotoxicity were found only in the «CTX+Amikacin» Group (in 4/20 (5%)). There were no such cases in «Amikacin+Cytofl avin» Group consisting of 23 patients.

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Otoprotective and antioxidant activity of cytoflavin in pulmonary tuberculosis patients receiving amikacin

Solokha,

Tursunova,

Stavitskaya

et al. 2023

Tuberk. bolezni lëgk.

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show abstract

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Current Methods of Prevention of Aminoglycoside Ototoxicity in Patients with Pulmonary Tuberculosis

Cited by 1 publication

References 40 publications

Otoprotective and antioxidant activity of cytoflavin in pulmonary tuberculosis patients receiving amikacin

Otoprotective and antioxidant activity of cytoflavin in pulmonary tuberculosis patients receiving amikacin

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