Current methods for the synthesis of 2-substituted azoles

Five‐Membered Heterocycles: 1,3‐Azoles

“…On the other hand, electrophilic substitution is by far the most common method for substitution at the 2-position of substituted 1,3-azoles [157]. With this aim the addition of electrophiles as acid chlorides [158] or aldehydes [159] has been studied.…”

Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles

“…As a result, both the introduction of new methodologies and the developments of the already reported synthesis of imidazoles have created great interest in universities' research laboratories as well as in industry. Consequently, an increasing amount of worldwide research has grown in the area of synthesis, functionalization, and derivatization of the imidazole scaffold [8][9][10][11][12][13][14][15][16][17][18][19][20][21]. A literature survey revealed several useful reviews on the synthesis of imidazoles [22][23][24][25][26]-among them a comprehensive review published in Tetrahedron in 2007 [22].…”

Site-Selective and Stereoselective C(sp3)–H Borylation of Alkyl Side Chains of 1,3-Azoles with a Silica-Supported Monophosphine-Iridium Catalyst

“…1 Therefore, functionalization of the alkyl side chain of 1,3--azoles is of great importance for construction of complex molecules containing 1,3--azole scaffolds. 2 Among the methods for functionalization of alkyl groups, C(sp 3 )-H borylation is attractive because alkylboron compounds are versatile synthetic intermediates with broad functional group compatibility, and air--and moisture stability. 3,4 Despite recent significant progress in this area, the site--selective borylation of unactivated C(sp 3 )-H bonds over potentially more reactive C-H bonds such as C(sp 2 )-H bonds remains challenging.…”