Current methods for laboratory diagnosis of rheumatoid arthritis

Новиков, А. А.; Александрова, Е. Н.; Черкасова, М. В.; Насонов, Евгений Львович

doi:10.14412/1995-4484-2010-1404

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…The development of RA is associated with the formation of a wide spectrum of autoantibodies, including rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs) (antiperinuclear factor, antikeratin antibodies, antibodies to cyclic citrullinated peptide (anti-CCP), modified citrullinated vimentin, anti-MCV, citrullinated fibrinogen, etc. ), the presence of which contributes substantially to the course and prognosis of disease [ 2 , 3 ]. At present, ACPA-positive and ACPA-negative RA subtypes are identified, which differ in molecular mechanisms of pathogenesis, severity course and approaches to the treatment administered [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

Авдеева

Aleksandrova

Novikov

et al. 2014

International Journal of Rheumatology

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Objective. To make individualised decisions regarding treatment is one of the most important challenges in clinical practise, and identification of sensitive and specific markers of prognosis is an important research question. The main objective of this study was to evaluate relationships between the level of autoantibodies, radiographic changes and laboratory markers of bone, and cartilage destruction. Methods. A total of 114 RA patients were examined. The serum concentration of IgM RF, antibodies to cyclic citrullinated peptide (anti-CCP), modified citrullinated vimentin (anti-MCV), matrix metalloproteinase 3 (MMP-3), and cartilage oligomeric matrix protein (COMP, ng/mL) were measured. The van der Heijde-modified Sharp Score was used to quantify the radiologic changes. Results. Among the patients who were high-positive for anti-MCV, the value of total modified Sharp score (mTSS) (96.5; 66–120) was higher as well as the joint space narrowing (82; 60.5–105.5), and a higher level of MMP-3 was recorded more frequently (56%) in comparison with negative/low-positive patients (57; 31–88, 50; 29–82, 31% resp., P < 0.05). The level of COMP was also higher among patients high-positive for anti-MCV (9.7; 8.1–13.1 and 6.8; 5.4–10.7, resp., P = 0.02). Conclusion. A high positive level of anti-MCV as contrasted with anti-CCP and IgM RF is associated with more pronounced destructive changes in the joints.

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Section: Introductionmentioning

confidence: 99%

The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

Авдеева

Aleksandrova

Novikov

et al. 2014

International Journal of Rheumatology

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Immunological Diagnostics Systemic Connective Tissue Diseases

Borisova¹

2020

Clinical Medicine and Pharmacology

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Modern clinical immunology makes it possible to conduct fairly effective laboratory diagnostics of immuno-inflam-matory rheumatic diseases (IVRS). The applied methods make it possible to obtain objective information about the nature of immunopathological changes, being an important tool for diagnosis, assessment of activity, determining the prognosis, choosing a treatment method for the disease and monitoring the effectiveness of therapy. Currently, the optimal choice and use of immunological methods is possible. The main goal of laboratory diagnostics of IVRS is to obtain objective information about the presence and nature of immunopathological changes in the examined patient, which is an important tool for early diagnosis, assessment of activity, severity of the course, prognosis of the disease and the effectiveness of therapy.

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Rheumatoid arthritis in the practice of a nurse of therapeutic profile

Akhverdyan

Заводовский²,

Polyakova³

et al. 2021

Medsestra (Nurse)

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The article discusses various aspects of rheumatic diseases that are most common in therapeutic practice. The most detailed information is provided on rheumatoid arthritis (etiology, pathogenesis), clinical symptoms and the basics of laboratory diagnostics are described in detail. The key issues of the significance of osteoporosis as one of the most serious complications of rheumatoid arthritis are discussed separately.

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Current methods for laboratory diagnosis of rheumatoid arthritis

Cited by 3 publications

References 60 publications

The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

Immunological Diagnostics Systemic Connective Tissue Diseases

Rheumatoid arthritis in the practice of a nurse of therapeutic profile

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