Current metabolomics: Practical applications

Putri, Sastia Prama; Nakayama, Yasumune; Mizutani, Fumio; Uchikata, Takato; Kobayashi, Shizu; Matsubara, Atsuki; Fukusaki, Eiichiro

doi:10.1016/j.jbiosc.2012.12.007

Cited by 249 publications

(135 citation statements)

References 135 publications

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“…In addition, cultivar, production area, post-harvest process were also discriminated by the prediction model. 8,33) e above results clearly indicate a power of metabolic ngerprinting as a discrimination tool for traditional medicine. In future, a utilization of metabolic ngerprinting on the o cial evaluation will be expected.…”

Section: Application To Quality Analysis Of Traditional Herbal Medicinementioning

confidence: 67%

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Application of Metabolomics for High Resolution Phenotype Analysis

Fukusaki

2014

Mass Spectrometry

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Metabolome, a total pro le of whole metabolites, is placed on downstream of proteome. Metabolome is thought to be results of implementation of genomic information. In other words, metabolome can be called as high resolution phenotype. e easiest operation of metabolomics is the integration to the upstream ome information including transcriptome and/or proteome. ose trials have been reported at a certain scienti c level. In addition, metabolomics can be operated in stand-alone mode without any other ome information. Among metabolomics tactics, the author's group is particularly focusing on metabolic ngerprinting, in which metabolome information is employed as explanatory variant to evaluate response variant. Metabolic ngerprinting technique is expected not only for analyzing slight di erence depending on genotype difference but also for expressing dynamic variation of living organisms. e author introduces several good examples which he performed. ose are useful for easy understanding of the power of metabolomics. In addition, the author mentions the latest technology for analysis of metabolic dynamism. e author's group developed a facile analytical method for semi-quantitative metabolic dynamism. e author introduces the novel method that uses time dependent variation of isotope distribution based on stable isotope dilution.

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Section: Application To Quality Analysis Of Traditional Herbal Medicinementioning

confidence: 67%

“…e recent application research of metabolomics are well documented in the review. 8) e author introduces several good examples which he performed. ose are useful for easy understanding of the power of metabolomics.…”

Section: Introductionmentioning

confidence: 99%

Application of Metabolomics for High Resolution Phenotype Analysis

Fukusaki

2014

Mass Spectrometry

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“…ere are many comprehensive review articles on the basic concepts, methodology, and examples of the application of metabolomics, which are cited in the subsequent sections of this article. 11,[14][15][16][17][18][19] …”

Section: )mentioning

confidence: 99%

Technical Challenges in Mass Spectrometry-Based Metabolomics

Mizutani

2016

Mass Spectrometry

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Metabolomics is a strategy for analysis, and quanti cation of the complete collection of metabolites present in biological samples. Metabolomics is an emerging area of scienti c research because there are many application areas including clinical, agricultural, and medical researches for the biomarker discovery and the metabolic system analysis by employing widely targeted analysis of a few hundred preselected metabolites from 10-100 biological samples. Further improvement in technologies of mass spectrometry in terms of experimental design for larger scale analysis, computational methods for tandem mass spectrometry-based elucidation of metabolites, and speci c instrumentation for advanced bioanalysis will enable more comprehensive metabolome analysis for exploring the hidden secrets of metabolism.

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“…Modern challenges for metabolomics are diverse in all the ields mentioned, but they are particularly relevant in the discovery of biomarkers [82], especially in the ield of diseases, because their detection, monitoring and treatment are important. One of the problems that researchers face these days is the diiculty in the identiication and quantiication of several chemical compounds at the same time in a reliable and ideal way, since their number can be huge, and some metabolites, which may be undetectable due to their low concentrations, may be relevant to some function or application.…”

Section: Future Perspectives Of Metabolomicsmentioning

confidence: 99%

Metabolomics as a Tool in Agriculture

Ibarra-Estrada¹,

Soto-Hernández²,

Palma-Tenango³

2016

Metabolomics - Fundamentals and Applications

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Metabolomics is a study through can be obtain a beter understanding of the complexity of the biological systems, through the chemical composition and relations with the physiology of the plant. The literature describes a lot of information on this support in areas of medicinal plants, chemosystematics, adulteration of plants, etc., but it is scarce in agriculture. At present, agriculture plays a crucial role in human beings. The demand of foods has increased due to the continuous increase in the population, and this requires an increase in the production of crops, besides the crops being afected by the climatic change, atack of pest and diseases and resistance to a conventional agrochemicals. At present, scientists are doing some practices or studies of genetic improvement of crops to increase their production and avoid the problems pointed out. It is an important part of the genomic studies; the results could be the basis for a genetic improvement based on the chemical composition of the crops, and in the metabolomics studies represent a crucial role in their quality for human consumption. The aim of the chapter is to review the literature from 10 years behind emphasizing the importance of metabolomics in crops of economic and feed value.

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Current metabolomics: Practical applications

Cited by 249 publications

References 135 publications

Application of Metabolomics for High Resolution Phenotype Analysis

Application of Metabolomics for High Resolution Phenotype Analysis

Technical Challenges in Mass Spectrometry-Based Metabolomics

Metabolomics as a Tool in Agriculture

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