Current mechanistic insights into the role of infection in systemic lupus erythematosus

Liu, Zejian; Liao, Shuzhen; Lin, Yi; Lü, Xing; Chen, Xiaoqun; Li, Zhihang; Li, Xinxin; Xu, Yong‐Zhi; Liu, Huafeng

doi:10.1016/j.biopha.2019.109122

Cited by 40 publications

(36 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, viral infections can interact with the host immune system through several mechanisms which ultimately lead to the loss of tolerance, the production of autoantibodies, the tissue deposition of immune complexes and consequent tissue damage. These are: structural or functional molecular mimicry, epitope spreading, superantigen production, bystander activation, altered apoptosis and clearance deficit, epigenetic factors, persistent or recurrent viral infection, and innate immunity activation with type I IFN production [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: General Mechanisms Of Virus-induced Autoimmunitymentioning

confidence: 99%

“…Molecular mimicry Viral antigens with structural similarity with self-antigens can be presented to and activate autoreactive T-lymphocytes. [8,9,[14][15][16][17][18] Epitope-spreading Over time, persistent viral infection elicits autoantibodies directed not only towards initial antigens but also multiple epitopes of the same antigens or even different antigens, increasing breadth of immune response.…”

Section: Mechanism Description Referencesmentioning

confidence: 99%

“…Among these, EBV has the strongest evidence as an etiological candidate, and a definite association seems to exist also with B19V and RV. The strength of association is variable for other viruses [14].…”

Section: Role Of Specific Viral Infections In Slementioning

confidence: 99%

See 2 more Smart Citations

Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story

Quaglia

Merlotti

Andrea

et al. 2021

Viruses

View full text Add to dashboard Cite

A causal link between viral infections and autoimmunity has been studied for a long time and the role of some viruses in the induction or exacerbation of systemic lupus erythematosus (SLE) in genetically predisposed patients has been proved. The strength of the association between different viral agents and SLE is variable. Epstein–Barr virus (EBV), parvovirus B19 (B19V), and human endogenous retroviruses (HERVs) are involved in SLE pathogenesis, whereas other viruses such as Cytomegalovirus (CMV) probably play a less prominent role. However, the mechanisms of viral–host interactions and the impact of viruses on disease course have yet to be elucidated. In addition to classical mechanisms of viral-triggered autoimmunity, such as molecular mimicry and epitope spreading, there has been a growing appreciation of the role of direct activation of innate response by viral nucleic acids and epigenetic modulation of interferon-related immune response. The latter is especially important for HERVs, which may represent the molecular link between environmental triggers and critical immune genes. Virus-specific proteins modulating interaction with the host immune system have been characterized especially for Epstein–Barr virus and explain immune evasion, persistent infection and self-reactive B-cell “immortalization”. Knowledge has also been expanding on key viral proteins of B19-V and CMV and their possible association with specific phenotypes such as antiphospholipid syndrome. This progress may pave the way to new therapeutic perspectives, including the use of known or new antiviral drugs, postviral immune response modulation and innate immunity inhibition. We herein describe the state-of-the-art knowledge on the role of viral infections in SLE, with a focus on their mechanisms of action and potential therapeutic targets.

show abstract

Section: General Mechanisms Of Virus-induced Autoimmunitymentioning

confidence: 99%

Section: Mechanism Description Referencesmentioning

confidence: 99%

See 1 more Smart Citation

Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story

Quaglia

Merlotti

Andrea

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…The signaling cascade downstream of Toll-like receptors (TLRs) is a major pathway controlled by that miRNAs, such as miR-155, miR-125b, miR-223, let-7i, and let-7e [41]. Based on the investigation of miRNAs in sepsis [42]. Shilei et al explored the association of miR-125a and miR-125b with the ARDS risk.…”

Section: At the Genetic Level Genetic Testing Makes Facilitates The mentioning

confidence: 99%

From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

Hao

Tang

2020

Bioscience Reports

View full text Add to dashboard Cite

A healthy body activates the immune response to target invading pathogens (i.e. viruses, bacteria, fungi, and parasites) and avoid further systemic infection. The activation of immunological mechanisms includes several components of the immune system, such as innate and acquired immunity. Once any component of the immune response to infections is aberrantly altered or dysregulated, resulting in a failure to clear infection, sepsis will develop through a pro-inflammatory immunological mechanism. Furthermore, the severe inflammatory responses induced by sepsis also increase vascular permeability, leading to acute pulmonary edema and resulting in acute respiratory distress syndrome (ARDS). Apparently, potential for improvement exists in the management of the transition from sepsis to ARDS; thus, this article presents an exhaustive review that highlights the previously unrecognized relationship between sepsis and ARDS and suggests a direction for future therapeutic developments, including plasma and genetic pre-diagnostic strategies and interference with proinflammatory signaling.

show abstract

“…MicroRNAs (miRNA) are universal non-coding RNAs that regulate the expressions of target genes via inhibiting the translation or depredation of mRNA and accumulating evidences indicate that miRNAs are involved in the regulation of the immune response and inflammation. 6,7 MiR-125a and miR-125b, which belong to miR-125 family, have been reported to be involved in various processes of immune responses and inflammation. 8,9 For instance, miR-125a high expression is reported to contribute to the upregulation of inflammatory cytokines and chemokines, such as IL-β, IL-6, and TNF-α, in lupus nephritis.…”

Section: Introductionmentioning

confidence: 99%

Correlation of microRNA‐125a/b with acute respiratory distress syndrome risk and prognosis in sepsis patients

Zhao

Cui

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Objective This study was conducted to explore the association of microRNA (miR)‐125a and miR‐125b with acute respiratory distress syndrome (ARDS) risk and to investigate their correlation with clinical characteristics and prognosis in sepsis patients. Methods Totally 150 sepsis patients admitted to our hospital were consecutively enrolled and another 150 healthy subjects were enrolled as healthy controls (HCs). Their blood samples were collected for miR‐125a and miR‐125b detection by real‐time quantitative polymerase chain reaction. Besides, ARDS occurrence and 28‐day mortality were documented in all sepsis patients. Results MiR‐125a and miR‐125b relative expressions were increased in ARDS‐sepsis patients/non‐ARDS‐sepsis patients compared with HCs, while only miR‐125b but not miR‐125a was elevated in ARDS‐sepsis patients compared with non‐ARDS‐sepsis patients. Receiver operating characteristic (ROC) curve presented that miR‐125a (AUC: 0.650, 95%CI: 0.549‐0.750) and miR‐125b (AUC: 0.739, 95%CI: 0.653‐0.823) could differentiate ARDS‐sepsis patients from non‐ARDS‐sepsis patients, and miR‐125b was of increased predictive value compared with miR‐125a numerically. In sepsis patients, miR‐125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR‐125b was positively associated with Scr, C‐reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease. All sepsis patients were categorized into survivors and deaths according to 28‐day mortality, and miR‐125b but not miR‐125a was upregulated in deaths compared with survivors. Conclusion Both of miR‐125a and miR‐125b predict ARDS risk, while only miR‐125b is of value in prognosis prediction in sepsis patients.

show abstract

Current mechanistic insights into the role of infection in systemic lupus erythematosus

Cited by 40 publications

References 56 publications

Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story

Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story

From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

Correlation of microRNA‐125a/b with acute respiratory distress syndrome risk and prognosis in sepsis patients

Contact Info

Product

Resources

About