Current Management of Low-Grade Astrocytomas of Childhood

Sutton, Leslie N.

doi:10.1159/000120311

Cited by 22 publications

(11 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complete resection is the goal in surgical treatment of PAs (12). In the hypothalamic/chiasmatic region, however, GTR is difficult and carries a risk of damage to the pituitary gland, optic apparatus, hypothalamic structures, and carotid arteries (28). This raises several important questions regarding the longterm behavior of residual tumor.…”

Section: Discussionmentioning

confidence: 99%

Pilocytic and Pilomyxoid Hypothalamic/Chiasmatic Astrocytomas

et al. 2004

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Pilocytic and Pilomyxoid Hypothalamic/Chiasmatic Astrocytomas

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Systemic chemotherapy has been used to treat children under 3-5 years of age, children with disease progression despite radiation therapy, and patients with multicentric disease [20,[25][26][27][28][29]. Chemotherapy is an alternative to external irradiation in patients under 3-5 years of age, thereby avoiding the deleterious effects of radiation therapy [6,13,26,30].…”

Section: Discussionmentioning

confidence: 99%

“…Low grade gliomas are sensitive to chloroethylnitrosoureas [26]. Response or stabilization have been reported using different multi-agent chemotherapy protocols: actinomycin D and vincristine [25,28]. B CNU and 5-fluorouracil [26], 6-thioguanine, procarbazine, dibromodulcitol, CCNU, and vincristine [20,26], and CCNU [29].…”

Section: Discussionmentioning

confidence: 99%

Unusual early recurrence of a cerebellar pilocytic astrocytoma following complete surgical resection

et al. 1996

View full text Add to dashboard Cite

Pilocytic cerebellar astrocytomas are usually benign tumors with generally an excellent prognosis following complete surgical resection. The goal of surgery is total resection to minimize the risk of recurrence. In this case report, a 5-year old boy who had undergone total resection of a posterior fossa pilocytic cerebellar astrocytoma (as documented by a contrast-enhanced computed tomography (CT) scan within 24 hours following surgery), developed a massive recurrence of the tumor within four months. Both the initial histology and the sections examined after the second resection revealed features typical for a pilocytic astrocytoma with no suspicion of malignancy. This case is unusual in that it is contrary to other reports suggesting that CT-documented complete surgical resection of pilocytic astrocytomas is without recurrence, and suggests the need for vigilant radiographic and clinical follow-up of these patients even if apparent complete resection of the tumor has been achieved.

show abstract

“…Typically located near the foramen of Monroe, SEGAs may cause hydrocephalus as a result of outflow obstruction. As these tumors are usually not sensitive to irradiation or chemotherapy, surgical resection is the treatment of choice [39]. Recently, rapamycin has been shown to cause regression of astrocytomas in TSC [40•].…”

Section: Tuberous Sclerosis Complexmentioning

confidence: 99%

Update on the management of familial central nervous system tumor syndromes

Hottinger¹,

Khakoo

2007

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

Hereditary central nervous tumor syndromes are a varied group of conditions that include neurofibromatosis type 1 and 2, tuberous sclerosis, Von Hippel-Lindau disease, and Cowden, Turcot, and Gorlin syndromes. The responsible genes have been identified in most of these disorders. These genes typically act as tumor suppressor genes, maintain normal cellular function and homeostasis, and regulate cell growth and differentiation. Familial central nervous system tumors are mostly inherited as autosomal dominant traits and involve germline mutations. Neoplastic development occurs when a somatic mutation inactivates the second allele. These patients also present unique challenges for their management. This review highlights the clinical manifestations, molecular genetics, pathophysiology, and current treatment options of these disorders with a focus on neuro-oncologic manifestations of the diseases.

show abstract

Current Management of Low-Grade Astrocytomas of Childhood

Cited by 22 publications

References 58 publications

Pilocytic and Pilomyxoid Hypothalamic/Chiasmatic Astrocytomas

Pilocytic and Pilomyxoid Hypothalamic/Chiasmatic Astrocytomas

Unusual early recurrence of a cerebellar pilocytic astrocytoma following complete surgical resection

Update on the management of familial central nervous system tumor syndromes

Contact Info

Product

Resources

About