Current management of gastric cancer

Abstract

Gastric cancer is a disease with high incidence and mortality in our population. The prognosis of patients with this disease is closely related to the neoplasm stage at diagnosis, including the following characteristics of the tumor: extension into the gastric wall thickness, spread to locoregional lymph nodes and the ability to generate distant metastases, as described by the TNM classification. For localized tumors characterized only by invasion of mucosa or submucosa at diagnosis, survival at 5 years is between 70 and 95% with exclusive surgical management; however, when extension into the gastric wall is higher and/or there is locoregional nodal involvement, survival decreases to 20-30% at 5 years. Currently, at high-volume centers, the extent of gastrectomy is individualized based on several parameters, which in an increasing number of cases allows a total gastrectomy with D2 lymphadenectomy and preservation of the spleen and pancreas. This improved procedure increases the chance of R0 surgery and improves the relationship between resected and affected lymph nodes, resulting in a decreased risk of the long-term locoregional recurrence. To improve these results, different therapeutic strategies combining chemotherapy or chemoradiotherapy with surgery have been tested. Previously, the Intergroup 0116 clinical trial, published in 2001, which changed clinical practice in the United States, showed that adjuvant chemoradiotherapy improved survival (from 26 to 37 months overall survival) of these patients. In Europe, perioperative chemotherapy has been considered the standard treatment, since the publication of two randomized phase III trials showed an increase at 5 years survival in the group treated with chemotherapy.

Endoscopic ultrasound and endoscopic ultrasound-guided fine needle aspiration in the diagnosis of diffuse gastrointestinal lesions with inconclusive endoscopic biopsies

“…This study showed promising results for EUS-FNA in the biopsy negative diffuse gastrointestinal lesions with a very high PPV reaching 100%, an NPV of 61.98%, a sensitivity of 83%, and a specificity of 100% with a p<0.0001. Our current results go hand in hand with many previous studies (12)(13)(14)(15).…”

Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity ofBCL-2family gene members in stomach cancer cells

“…3 These findings reveal that the choice of any chemotherapy regimen is essentially dependent upon each patient's profile. 45 Consequently, any difficulties related to currently available therapies could be surmounted via the necessary exploration of gastric cancer-specific molecular indicators. Their future incorporation in clinical practice will be expected to assist in better forecasting response to chemotherapy and general monitoring of disease outcome.…”

Erweiterte pathohistologische Kriterien zur Bewertung der Langzeitprognose des Magenkarzinoms

“…Darüber hatten alle TNM-assozierten Kriterien ebenfalls erwartungsgemäß einen hochsignifikanten Einfluss auf das Patientenüberleben und die Rezidivhäufigkeit. In der aktuellen Novellierung der TNM-Klassifikation wurde die Perineuralscheideninfiltration als neues Kriterium hinzugefügt, auch dieser Marker erwies sich in unserer Analyse als hochsignifikanter Prognosefaktor [22]. Zahlreiche Arbeiten weisen auf die prognostische Bedeutung erweiterter pathohistologischer Prognosekriterien hin.…”