Current management of aspirin‐exacerbated respiratory disease

Scadding, Glenis

doi:10.1002/psb.938

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CRS and nasal polyps can be identified by CT, x-ray, rhinoscopy, or nasal endoscopy [7,34]. Since AERD is not an IgE-mediated reaction, skin prick test using NSAIDs are useless [133].…”

Section: Other Diagnostic Methodsmentioning

confidence: 99%

Aspirin exacerbated respiratory disease: Current topics and trends

Rodríguez-Jiménez

Moreno-Paz

Terán

et al. 2018

Respiratory Medicine

View full text Add to dashboard Cite

Aspirin-exacerbated respiratory disease is a chronic and treatment-resistant disease, characterized by the presence of eosinophilic rhinosinusitis, nasal polyposis, bronchial asthma, and nonsteroidal anti-inflammatory drugs hypersensitivity. Alterations in arachidonic acid metabolism may induce an imbalance between pro-inflammatory and anti-inflammatory substances, expressed as an overproduction of cysteinyl leukotrienes and an underproduction of prostaglandin E2. Although eosinophils play a key role, recent studies have shown the importance of other cells and molecules in the development of the disease like mast cells, basophils, lymphocytes, platelets, neutrophils, macrophages, epithelial respiratory cells, IL-33 and thymic stromal lymphopoietin, making each of them promissory diagnostic and treatment targets. In this review, we summarize the most important clinical aspects of the disease, including the current topics about diagnosis and treatment, like provocation challenges and aspirin desensitization. We also discuss recent findings in the pathogenesis of the disease, as well as future trends in diagnosis and treatment, including monoclonal antibodies and a low salicylate diet as a treatment option.

show abstract

“…CRS and nasal polyps can be identified by CT, x-ray, rhinoscopy, or nasal endoscopy [7,34]. Since AERD is not an IgE-mediated reaction, skin prick test using NSAIDs are useless [133].…”

Section: Other Diagnostic Methodsmentioning

confidence: 99%

Aspirin exacerbated respiratory disease: Current topics and trends

Rodríguez-Jiménez

Moreno-Paz

Terán

et al. 2018

Respiratory Medicine

View full text Add to dashboard Cite

show abstract

Topical nasal lysine aspirin in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis with nasal polyposis

Parikh

Scadding

2014

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Chronic rhinosinusitis patients with nasal polyps can be aspirin sensitive or aspirin tolerant. The majority belong to the latter group. They tolerate intake of aspirin or other non-steroidal anti-inflammatory drugs, whereas aspirin-sensitive patients have an adverse reaction (asthma, rhinitis and/or urticaria). Diagnosis of aspirin sensitivity is important for the patient, but is rarely undertaken in routine ENT or respiratory medicine practice. Treatment of nasal polyps is by a combination of medical therapy and surgery. Oral and topical steroids form the mainstay of medical therapy, which is aimed at reducing inflammation and symptom improvement. Surgery helps with polyps causing severe nasal obstruction. Despite these therapies, recurrences are common in aspirin sensitive patients. Any adjunctive therapy to prevent or prolong recurrence would be welcome. One such possibility is topical nasal lysine-aspirin. This is an area under current debate and this non-systematic review aims to provide evidence of its use, to date, in aspirin sensitive and aspirin tolerant nasal polyp patients.

show abstract

Current management of aspirin‐exacerbated respiratory disease

Abstract: The diagnosis of aspirin and NSAID hypersensitivity can help the patient avoid further exacerbations. Dr Scadding describes the respiratory reactions seen in aspirin‐exacerbated respiratory disease and the various approaches to management.

Cited by 2 publications

References 8 publications

Aspirin exacerbated respiratory disease: Current topics and trends

Aspirin exacerbated respiratory disease: Current topics and trends

Topical nasal lysine aspirin in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis with nasal polyposis

Contact Info

Product

Resources

About