Current Management and Controversies Surrounding Andropause

Mian, Abrar; Yang, David Y.; Köhler, Tobias

doi:10.1016/j.ucl.2022.07.003

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…et al, 2022 ), lowers the risk of breast cancer (in Korea) ( Baek et al, 2022 ), and reduces COVID-19 deaths ( Sund et al, 2022 ). Testosterone replacement therapy (TRT) is recommended for late-onset hypogonadism in aging males over 65 years old ( Nieschlag, 2020 ; Burte et al, 2021 ), but it is still a subject of controversy ( Diokno, 2022 ; Mian et al, 2022 ). Regardless of testosterone levels, most symptomatic late-onset hypogonadism has been shown not to be correlated ( Li et al, 2020c ; Ishikawa et al, 2020 ; La Vignera et al, 2020 ; Tsuru et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Phua

2023

Front. Aging

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Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely associated with human age-related carcinogenesis and chronic diseases. However, the connection between hypoxia and hormonal cell signaling pathways is unclear, but such human age-related comorbid diseases do coincide with the middle-aging period of declining sex hormonal signaling. This scoping review evaluates the relevant interdisciplinary evidence to assess the systems biology of function, regulation, and homeostasis in order to discern and decipher the etiology of the connection between hypoxia and hormonal signaling in human age-related comorbid diseases. The hypothesis charts the accumulating evidence to support the development of a hypoxic milieu and oxidative stress-inflammation pathophysiology in middle-aged individuals, as well as the induction of amyloidosis, autophagy, and epithelial-to-mesenchymal transition in aging-related degeneration. Taken together, this new approach and strategy can provide the clarity of concepts and patterns to determine the causes of declining vascularity hemodynamics (blood flow) and physiological oxygenation perfusion (oxygen bioavailability) in relation to oxygen homeostasis and vascularity that cause hypoxia (hypovascularity hypoxia). The middle-aging hypovascularity hypoxia hypothesis could provide the mechanistic interface connecting the endocrine, nitric oxide, and oxygen homeostasis signaling that is closely linked to the progressive conditions of degenerative hypertrophy, atrophy, fibrosis, and neoplasm. An in-depth understanding of these intrinsic biological processes of the developing middle-aged hypoxia could provide potential new strategies for time-dependent therapies in maintaining healthspan for healthy lifestyle aging, medical cost savings, and health system sustainability.

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Section: Discussionmentioning

confidence: 99%

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Phua

2023

Front. Aging

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Couplepause: deconstructing sick menopause and andropause during midlife

Rozenberg,

Nappi,

Schaudig

et al. 2023

The Journal of Sexual Medicine

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Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans

Cornejo Ulloa,

Krom,

Schoonmade

et al. 2024

Front. Endocrinol.

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Sex steroid hormones (SSH) are extremely versatile molecules with a myriad of physiological functions. Next to their well-known role in sexual development and reproduction, SSH play active roles in practically every tissue in the human body, including the oral cavity. It has long been demonstrated that periodontal tissues express SSH receptors and therefore are responsive to the presence of SSH. Interestingly, SSH not only interact with the periodontal tissues but also with other tissues in the oral cavity such as dental enamel, pulp, cementum, oral mucosa, and salivary glands. Questions concerning the possible physiological functions of these receptors and their role in maintenance of oral health, remain unanswered. The purpose of this scoping review was to gather and summarize all the available evidence on the role of SSH in physiological processes in the oral cavity in humans. Two comprehensive literature searches were performed. References were screened and selected based on title, abstract and full text according to our inclusion criteria. Both searches yielded 18,992 results of which 73 were included. Results were divided into four categories: (1) Periodontium; (2) Dental structure; (3) Mucosa; and (4) Salivary glands. The interaction of these tissues with progestagens, androgens and estrogens are summarized. Sex steroid hormones are an overlooked yet fundamental factor in oral homeostasis. They play important roles in the development and function of the periodontium, dental structure, mucosa and salivary glands. Dentists and healthcare providers should consider these hormonal factors when assessing and treating oral health conditions.

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Current Management and Controversies Surrounding Andropause

Cited by 4 publications

References 65 publications

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Couplepause: deconstructing sick menopause and andropause during midlife

Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans

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