Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

El-Hajj, Victor Gabriel; Pettersson-Segerlind, Jenny; Fletcher‐Sandersjöö, Alexander; Edström, Erik; Elmi-Terander, Adrian

doi:10.3390/cancers14246251

Cited by 15 publications

(47 citation statements)

References 91 publications

(229 reference statements)

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“…PSAM is extremely understudied due to its rarity ( Table 2 ). Spinal meningioma is generally considered to have female predilection and the corresponding male to female ratio ranges from 1:1.5 to 1:14.5 ( 2 , 19 , 20 ). However, the numbers of male and female patients are even in our small sample.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, spinal meningiomas most frequently occur in older patients ( 22 ). A systematic review concluded the average age of spinal meningiomas was 62.6 years old after adjusting the sample size of various studies ( 20 ). The median age of our patients was 25 (range, 13–46) years, while the median age of literature cases was 55 (range, 47–68) years ( 8 , 9 , 12 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

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Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

Wu¹,

Wang²,

Zou³

et al. 2023

Transl Cancer Res

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Background Primary spinal anaplastic meningioma (PSAM) is a very rare entity in the spinal canal. Therefore, the clinical features, treatment strategy, and long-term outcomes remain poorly studied. Case Description Clinical data of six patients with PSAM treated at one single institution were retrospectively analyzed and all previously reported cases in the English literature were reviewed. There were three male and three female patients with a median age of 25 years. The duration of symptoms before initial diagnosis ranged from one week to one year. PSAMs occurred at cervical level in four, cervicothoracic in one and thoracolumbar in one. In addition, PSAMs presented isointensity on T1 weighted imaging (WI), hyperintensity on T2WI, and hetero- or homogeneously marked enhancement with contrast. Eight operations were performed in six patients. Simpson II resection was achieved in four (50%), Simpson IV in three (37.5%), Simpson V in one (12.5%). Adjuvant radiotherapy was performed in five patients. With a median survival time of 14 months (4–136 months), three patients had recurrence, two experienced metastases, and four died of respiratory failure. Conclusions PSAMs are a rare disease, and there is limited evidence as to the management of these lesions. They may metastasize, recur, and portend a poor prognosis. A close follow-up and further investigation are therefore necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

Wu¹,

Wang²,

Zou³

et al. 2023

Transl Cancer Res

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“…Meta-analysis will only be performed for research questions where rigorous, homogeneous and sufficient data are available. A similar methodology has been described in several of our previous works 44–47…”

Section: Methods and Analysismentioning

confidence: 99%

Spontaneous spinal cord infarctions: a systematic review and pooled analysis protocol

El-Hajj,

Stenimahitis,

Gharios

et al. 2023

BMJ Open

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IntroductionSpinal cord infarction (SCInf) is a rare ischaemic event that manifests with acute neurological deficits. It is typically classified as either spontaneous, defined as SCInf without any inciting event, or periprocedural, which typically occur in conjunction with vascular surgery with aortic manipulations. While periprocedural SCInf has recently been the subject of intensified research, especially focusing on the primary prevention of this complication, spontaneous SCInf remains less studied.Methods and analysisElectronic databases, including PubMed, Web of Science and Embase, will be searched using the keywords “spinal cord”, “infarction”, “ischemia” and “spontaneous”. The search will be set to provide only English studies published from database inception. Editorials, letters and reviews will also be excluded. Reference lists of relevant records will also be searched. Identified studies will be screened for inclusion, by one reviewer in the first step and then three in the next step to decrease the risk of bias. The synthesis will address several topics of interest including epidemiology, presentation, diagnostics, treatment strategies, outcomes and predictors. The review aims to gather the body of evidence to summarise the current knowledge on SCInf. This will lead to a better understanding of the condition, its risk factors, diagnosis and management. Moreover, the review will also provide an understanding of the prognosis of patients with SCInf with respect to neurological function, quality of life and mortality. Finally, this overview of the literature will allow the identification of knowledge gaps to help guide future research efforts.Ethics and disseminationEthics approval was not required for our review as it is based on existing publications. The final manuscript will be submitted to a peer-reviewed journal.

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“…Spinal meningiomas remain a surgical disease due to a limited number of studies using non-surgical therapies. 78 Though pharmacotherapy is often discussed as a treatment for recurrent meningiomas, or those refractory to all surgical and RT modalities, 79 its role remains poorly defined with no reliable evidence on which to base recommendations for routine clinical use. 50 Many types of systemic therapy for solid CNS tumors have been studied for use in meningioma.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

The Natural History and Treatment of Meningiomas: An Update

Nyalundja,

Mugisha,

Karekezi

2023

Semin Neurol

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Meningiomas are the most frequent nonmalignant tumors of the central nervous system (CNS). Despite their benign nature and slow-growing pattern, if not diagnosed early, these tumors may reach relatively large sizes causing significant morbidity and mortality. Some variants are located in hard-to-access locations, compressing critical neurovascular structures, and making the surgical management even more challenging. Although most meningiomas have a good long-term prognosis after treatment, there are still controversies over their management in a subset of cases. While surgery is the first-line treatment, the use of fractionated radiotherapy or stereotactic radiosurgery is indicated for residual or recurrent tumors, small lesions, and tumors in challenging locations. Advances in molecular genetics and ongoing clinical trial results have recently helped both to refine the diagnosis and provide hope for effective biomolecular target-based medications for treatment. This article reviews the natural history and current therapeutic options for CNS meningiomas.

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Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

Cited by 15 publications

References 91 publications

Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

Spontaneous spinal cord infarctions: a systematic review and pooled analysis protocol

The Natural History and Treatment of Meningiomas: An Update

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