Current knowledge on genus Bassia All.: a comprehensive review on traditional use, phytochemistry, pharmacological activity, and nonmedical applications

Abstract

Bassia All. is a genus from the Amaranthaceae family, which was created by merging selected species belonging to the former Bassia and Kochia genera with those classified to Chenolea, Londesia, Kirilowia and Panderia. The reorganised Bassia genus currently comprises around 20 species, which are annual herbs or perennial subshrubs native to Eurasia and Africa. Bassia plants are well known for their therapeutic applications in folk medicine and traditional medical systems, and they are also used for nonmedical purposes. Some members of this genus, such as Bassia scoparia (syn. Kochia scoparia) is of great medical importance and economic value. The plant is cultivated in some regions of Asia as a crop to collect Kochiae fructus, which is used for both curative and food purposes. Phytochemical studies carried out on Bassia species indicate that these plants synthesize metabolites belonging to different groups of compounds (e.g., triterpene saponins, sterols, flavonoids, fatty acids, lignanamides, alkaloids, organic acids). Some of the structures are rarely found in the plant kingdom. Biological activity studies carried out on Bassia plants revealed various effects exerted by extracts and isolated compounds, including anti-inflammatory, cytotoxic, antioxidant, antimicrobial, hypoglycemic, anti-obesity, etc. Modern research explained some of the mechanisms of action. This review covers literature from 1935 to 2022, and assembles and discusses data on phytochemistry, biological activity, as well as medical and nonmedical use of the representatives of the genus Bassia. In this review we present the current state of knowledge about the plants of the genus.

Metabolites Profiling and Bioassays Reveal Bassia indica Ethanol Extract Protective Effect against Stomach Ulcers Development via HMGB1/TLR-4/NF-κB Pathway

“…In the present study, UPLC-ESI–Qtof-MS analysis has allowed for the comprehensive characterization of the BIEE metabolites via an untargeted approach ( Figure 9 ). In total, 40 metabolites were annotated mostly belonged to two main chemical classes, viz ., flavonoids and lipids, in line with the reported literature [ 31 ]. The identification strategy of the detected metabolites was based on their retention times, experimental m / z , molecular formulas, mass errors and their MS 2 fragments, as shown in ( Table 3 ).…”

“…In the present study, UPLC-ESI-Qtof-MS analysis has allowed for the comprehensive characterization of the BIEE metabolites via an untargeted approach (Figure 9). In total, 40 metabolites were annotated mostly belonged to two main chemical classes, viz., flavonoids and lipids, in line with the reported literature [31]. The identification strategy Methoxy flavonoids such as isorhamnetin and its glycosides have also been identified in the BIEE in agreement with the reported literature [35].…”

Pharmacognostic Evaluation, Chemical Characterization, and Antibacterial Activity of Bassia indica (Wight) A.J. Scott

“…The results of the current study were similar to the reported phytochemical profile of other plants of the genus Bassia like B. scoporia, and B. muricata, etc. [10,17,44]. The presence of phenols and flavonoids makes B. indica a plant of therapeutic potential.…”

“…: Kochia indica Wight] belongs to the family Amaranthaceae [9]. This family includes a large number of halophytes that are well-known for their therapeutic applications in traditional medical systems and are used for infected skin wounds, internal worms, fungal infections, renal and rheumatic disorders [10] as a cardiotonic [11], anti-inflammatory, and antioxidant [12]. B. indica is an annual herb found in Egypt, India, Pakistan, Northern Africa, Saudi Arabia, and other countries [13].…”

Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

“…Natural products are considered a rich reservoir of bioactive substances with therapeutic potential because of their chemical diversity [ 96 , 97 ]. Generally, drug discovery from plants for the treatment of BU, starts from an ethnobotanical survey to provide background information regarding the type of plant and plant part used, formulation (such as decoction, trituration, infusion, powders, maceration, pomade), and mode of administration (bandage, dermal) [ 98 ].…”