Current Knowledge in Thyroid Cancer—From Bench to Bedside

Grimm, Daniela

doi:10.3390/ijms18071529

Cited by 21 publications

(15 citation statements)

References 28 publications

(60 reference statements)

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“…The epidemiological statistics show that thyroid diseases, especially autoimmune thyroid diseases (AITDs) and thyroid cancers, are a serious problem [ 86 , 87 ]. According to the American Thyroid Association, around 20 million Americans suffer from some form of thyroid disease [ 88 ].…”

Section: Glycosylation In Thyroid Pathologymentioning

confidence: 99%

Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders

Ząbczyńska

Kozłowska

Pocheć

2018

IJMS

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The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins. Both thyroid-stimulating hormone (TSH) secreted by the pituitary gland and TSH receptors on the surface of thyrocytes contain N-glycans, which are crucial to their proper activity. Thyroglobulin (Tg), the protein backbone for synthesis of thyroid hormones, is a heavily N-glycosylated protein, containing 20 putative N-glycosylated sites. N-oligosaccharides play a role in Tg transport into the follicular lumen, where thyroid hormones are produced, and into thyrocytes, where hyposialylated Tg is degraded. N-glycans of the cell membrane transporters sodium/iodide symporter and pendrin are necessary for iodide transport. Some changes in glycosylation result in abnormal activity of the thyroid and alteration of the metabolic clearance rate of hormones. Alteration of glycan structures is a pathological process related to the progression of chronic diseases such as thyroid cancers and autoimmunity. Thyroid carcinogenesis is accompanied by changes in sialylation and fucosylation, β1,6-branching of glycans, the content and structure of poly-LacNAc chains, as well as O-GlcNAcylation, while in thyroid autoimmunity the main processes affected are sialylation and fucosylation. The glycobiology of the thyroid gland is an intensively studied field of research, providing new data helpful in understanding the role of the sugar component in thyroid protein biology and disorders.

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Section: Glycosylation In Thyroid Pathologymentioning

confidence: 99%

Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders

Ząbczyńska

Kozłowska

Pocheć

2018

IJMS

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“…The incidence of TC has progressively increased over several decades, and approximately 60,000 new cases in the US were diagnosed in 2018 (Fahey, Reeve, & Delbridge, ; Siegel, Miller, & Jemal, ), an estimated more than 90,000 TC cases occurred in China as well (Chen et al, ). In general, TC consists of four main subtypes including papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC; Grimm, ). PTC is classically characterized by its papillary‐like appearance, which represents the majority of TC types (Sherman, ).…”

Section: Introductionmentioning

confidence: 99%

PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer

Chen

You

et al. 2020

Dev Growth Differ

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Thyroid cancer (TC) is the most common malignant endocrine tumor, and its incidence has progressively increased over several decades. Accumulating evidence has suggested that PFKFB4, a critical regulatory enzyme of glycolysis, has been implicated in various solid cancers. However, the exact effect of PFKFB4 on TC remains unclear. Hence, the objective of this work was to investigate the role of PFKFB4 in TC and explore the underlying regulatory mechanisms. Here, we provide evidence that mRNA levels of PFKFB4 were upregulated in TC patients’ thyroids and cell lines. Downregulation of PFKFB4 reduced TC cell viability and inhibited colony formation. In addition, the migration and invasion of TC cells were suppressed by PFKFB4 knockdown, suggesting that PFKFB4 is positively correlated with tumorigenesis of TC. Molecularly, knockdown of PFKFB4 significantly inhibited expression of GCN5 and phosphorylation of PI3K/AKT. Moreover, the suppressive role of shPFKFB4 in TC cell growth was reversed by upregulation of GCN5. Finally, the in vivo experiment indicated that downregulation of PFKF4B suppressed tumor growth in xenografts TC model mice. In total, our results suggested that PFKFB4‐mediated TC tumorigenesis by positively regulating GCN5 and PI3K/AKT signaling. These findings provide new research directions and therapeutic options considering PFKF4B as a novel diagnosis marker and therapeutic target.

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“…Papillary and follicular cancers arising from thyroid follicular cells are classified as differentiated thyroid carcinomas (DTCs), and the prognosis is generally good. DTCs comprise 90% of thyroid cancers (1), and their incidence is growing worldwide (2,3). Thyroid cancer is currently the third fastest-growing cancer diagnosis in the USA, and the incidence has doubled in the last 30 years (4).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers

Çadırcı

Yıldız

Keskin

et al. 2020

Journal of Health Sciences and Medicine

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Amaç: Tiroid kanserleri endokrin kökenli en yaygın malign tümörlerdir. Tiroid kanserleri histopatolojik ve klinik davranışlara göre sınıflandırılır. Papiller ve foliküler kanserler diferansiye tiroid kanserleri (DTK) olarak sınıflandırılırlar. Son zamanlarda nötrofil/ lenfosit oranı (NLO) ve monosit/yüksek dansiteli lipoprotein kolesterol oranı (MHO) oksidatif stres ve sistemik inflamasyonun güçlü göstergeleri olduğu ve MHO' nun koroner ateroskleroz ile ilişkili koroner kalp hastalığında mortalitenin güçlü göstergeleri olduğu ortaya konuldu. Bu çalışmamızda DTK tanısı konulmuş olan hastalarımızda bu belirteçleri değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamıza DTK tanısı yeni konulan 125 hasta ve tamamen sağlıklı kişilerden oluşan 75 kişi kontrol grubu olarak dahil edildi. Hasta ve kontrol grubunun 12 saatlik açlık sonrası kolesterol parametreleri ve hematolojik parametreleri çalışılarak değerlendirmeye alındı. Bulgular: Hasta ve sağlıklı grubun sırası ile NLO ortalaması (3,2±2,8 ve 2,4±1,3 p=0,013) ve MHO (0,102±0,079 ve 0,038±0,052, p<0,001) şeklinde tespit edildi ve aralarında istatistiki açıdan anlamlı bir fark olduğu tespit edildi. Yapılan korelasyon analizinde ise NLO ile sırası ile beyaz küre (r=0,530, p<0,001), nötrofil (r=0,293, p<0,001) ve C reaktif protein (CRP) (r=0,371, p=0,005) arasında pozitif korelasyon tespit edilirken, NLO ile lenfosit arasında (r=-0,271, p=0,001) negatif korelasyon tespit edildi. Sonuç: Bu çalışma ile elde edilen verilere göre diferansiye tiroid kanserlerinin sistemik inflamasyonu artırdığı gözlenmektedir.

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Current Knowledge in Thyroid Cancer—From Bench to Bedside

Abstract: Thyroid cancer is the most common malignant endocrine tumour.[...]

Cited by 21 publications

References 28 publications

Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders

Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders

PFKFB4 negatively regulated the expression of histone acetyltransferase GCN5 to mediate the tumorigenesis of thyroid cancer

Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers

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