Current knowledge and tomorrows challenges of breast, ovarian and prostate cancer genetics

Hall, Per

doi:10.1111/j.1365-2796.2012.02527.x

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Identifying common low-penetrance variants [119,120]. The iCOGS array included 85278 SNPs, which were specifically chosen based on their potential relevance to PrCa, and was genotyped in 25,074 PrCa cases and 24,272 controls from 32 studies in the PRACTICAL consortium.…”

Section: Collaborative Genetic Study Consortiamentioning

confidence: 99%

Translating Genetic Risk Factors for Prostate Cancer to the Clinic: 2013 and Beyond

et al. 2014

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Prostate cancer (PrCa) is the most commonly diagnosed cancer in the male UK population, with over 40,000 new cases per year. PrCa has a complex, polygenic predisposition, due to rare variants such as BRCA and common variants such as single nucleotide polymorphisms (SNPs). With the introduction of genome-wide association studies, 78 susceptibility loci (SNPs) associated with PrCa risk have been identified. Genetic profiling could risk-stratify a population, leading to the discovery of a higher proportion of clinically significant disease and a reduction in the morbidity related to age-based prostate-specific antigen screening. Based on the combined risk of the 78 SNPs identified so far, the top 1% of the risk distribution has a 4.7-times higher risk of developing PrCa compared with the average of the general population.

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Section: Collaborative Genetic Study Consortiamentioning

confidence: 99%