Current issues on the understanding of locally advanced colorectal cancer

Habr‐Gama, Angelita; Perez, Rodrigo Oliva; Lynn, Patricio B.

doi:10.1590/s0004-28032011000400001

Cited by 3 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[7][8][9][10][11] Quanto à terapêutica, a operação ainda constitui a principal modalidade quando a intenção é curativa. 7,8,12 O treinamento específico e a experiência do cirurgião interferem significativamente na sobrevida de pacientes operados por CCR. 7,9,10 Outras formas de tratamento do CCR são a quimioterapia e radioterapia, podendo estas serem utilizadas como neoadjuvância ou adjuvância.…”

Section: Introductionunclassified

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Figueiredo¹,

Campos²,

Marcos³

et al. 2014

Revista Médica De Minas Gerais

View full text Add to dashboard Cite

RESUMOIntrodução: o câncer colorretal (CCR) é um tumor maligno frequente do aparelho digestivo e, no Brasil, representa a quarta causa de óbito. A sobrevida dos portadores de CCR é influenciada por uma série de variáveis, destacando-se o estadiamento tumoral. A principal modalidade terapêutica com perspectiva de cura é a cirúrgica, tendo como tratamentos adjuvantes a quimioterapia e a radioterapia. Objetivo: avaliar a sobrevida, bem como a taxa de complicações anastomótica dos pacientes com CCR acompanhados entre janeiro de 2007 e janeiro de 2013. Métodos: foi realizado estudo descritivo -série de casos com 171 pacientes. A variável dependente foi o tempo de sobrevida do CCR e as independentes foram faixa etária, sexo, sítio anatômico do tumor, infiltração tumoral e metástase linfonodal. Resultados: a sobrevida global dos pacientes com CCR no pós-operatório em 12, 24 e 36 meses de acompanhamento foi, respectivamente, de: 83,21, 76,56 e 63,47%. Acometimento linfonodal e o grau de infiltração tumoral representaram as variáveis relacionadas a pior prognóstico. Os sítios tumorais mais comuns foram o reto alto e sigmoide (43,75%), seguido do reto médio (18,75%) e reto baixo (18,75%). A deiscência anastomótica foi a complicação pós-operatória mais frequente (6,43%). Conclusão: a infiltração tumoral na parede intestinal e o número de linfonodos positivos influenciaram negativamente o tempo de vida dos pacientes com CCR. A fístula compreendeu a principal complicação anastomótica pós-operatória.Palavras-chave: Cirurgia Colorretal; Taxa de Sobrevida; Prognóstico. ABSTRACT Introduction: Colorectal cancer (CRC) is a common malignant tumor of digestive tract and, in Brazil, is the fourth leading cause of cancer. The survival of patients with CRC isinfluenced by a number of variables, especially the tumor staging. The main therapeutic modality with the prospect of cure is surgical, and as adjuvant chemotherapy and radiotherapy treatments. Objective: Evaluate survival, and the rate of anastomotic complications of patients with CCR followed between January 2007 and January 2013. Methods: This is a descriptive -series of cases study of 171 patients. The dependent variable was the survival time of the CCR and the independent variables were age, gender, anatomic site of the tumor, tumor infiltration and lymph node metastasis. Results: The overall survival of patients with CRC postoperatively in 12, were respectively 83.21%, 76.56% and 63.47%. The presence of lymph node involvement and the degree of tumor infiltration accounted for variables related to worse prognosis. The most common tumor sites were the rectum and sigmoid high (43.75%), followed by the rectum (18.75%) and lower rectum (18.75%). The anastomotic leak was the most common postoperative (6.43%) complication. Conclusion: The tumor infiltration in the intestinal wall and the number of positive nodes influenced negatively on the survival of patients Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

show abstract

Section: Introductionunclassified

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Figueiredo¹,

Campos²,

Marcos³

et al. 2014

Revista Médica De Minas Gerais

View full text Add to dashboard Cite

show abstract

Outcomes of Pelvic Exenteration for Locally Advanced and Recurrent Rectal Cancer

Jarrar

Steele

2021

Surgical Management of Advanced Pelvic Cancer

View full text Add to dashboard Cite

Հաստ Աղու Տեղային-Տարածված Քաղցկեղի Վիրաբուժական Բուժումը

Aleksanyan¹

2023

Medical Science of Armenia

View full text Add to dashboard Cite

На сегодняшний день хирургическое вмешательство остается наиболее эффективным и радикальным методом лечения местнораспространенного колоректального рака (КРР), позволяющим получить достоверные онкологические результаты после лечебных резекций R0. Сообщается, что результаты лечения после радикальных операций практически не отличаются от экстренных и плановых, а также после стандартных и мультиорганных резекций. В случае достаточной радикальности вмешательства получаются практически одинаковые результаты у больных с метастазами в регионарные лимфоузлы и без них. По этой причине радикальная резекция R0 некоторыми авторами принимается в качестве основного прогностического фактора у таких пациентов. В ряде работ важна стандартизация хирургического подхода для повышения эффективности лечения. В этом контексте также указывается важность совершенствования хирургической техники и организации лечения местнораспространенного КРР в специализированных центрах. В таких центрах частота радикальных резекций R0 достигает 94,4%, и параллельно снижается процент после- операционных осложнений и летальности. Как правило, радикальное удаление новообразований брюшной стенки и обширные лимфаденэктомии (ЛДЭ) в таких клиниках проводятся без значительных интраоперационных осложнений. Таким образом, данные литературы о результатах лечения местнораспространенного КРР, факторах, влияющих на послеоперационные осложнения, особенностях, способствующих рецидиву заболевания и прогнозе заболевания, изучены недостаточно, а полученные результаты часто противоречивы. В частности, неоднозначны мнения относительно объема ЛДЭ и их онкологической эффективности. Имеются противоречивые данные о факторах, способствующих послеоперационным осложнениям и рецидивам заболевания. По этой причине изучение таких вопросов остается актуальным для улучшения результатов хирургического лечения больных с местнораспространенным КРР. To date, surgical intervention remains the most effective and radical method of treating locally advanced colorectal cancer (CRC), which allows obtaining reliable oncological results after radical R0 resections. It has been reported that the results of treatment after radical surgery are practically not different between urgent and planned surgery, as well as between standard and multi-organ resections. In the case of sufficient radical intervention, almost similar results are obtained in patients with and without metastases in regional lymph nodes. For this reason, radical R0 resection is accepted by some authors as the main prognostic factor in such patients. A number of studies have highlighted the importance of standardizing the surgical approach to improve treatment efficacy. In this context, the importance of improving surgical technique and organizing the treatment of locally advanced CRC in specialized centers is also indicated. In such centers, the frequency of radical R0 resections reaches 94.4% and, in parallel, the percentage of postoperative complications and mortality decreases. As a rule, radical removal of neoplasms of the abdominal wall and extensive lymphadenectomy (LDE) in these clinics is performed without significant intraoperative complications. In conclusion, literature data on the results of treatment of locally advanced CRC, factors influencing postoperative complications, features contributing to disease recurrence and prognosis of the disease have not been studied enough, and the results obtained are often contradictory. In particular, there is no consensus regarding the volume of LDE and its oncological effectiveness. There are conflicting data on factors contributing to postoperative complications and recurrence of the disease. For this reason, the study of such issues remains relevant to improve the results of surgical treatment of patients with locally advanced CRC.

show abstract

Current issues on the understanding of locally advanced colorectal cancer

Cited by 3 publications

References 4 publications

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Retrospective evalution of survival for 171 patients with colorectal cancer after trhee years of follow-up

Outcomes of Pelvic Exenteration for Locally Advanced and Recurrent Rectal Cancer

Հաստ Աղու Տեղային-Տարածված Քաղցկեղի Վիրաբուժական Բուժումը

Contact Info

Product

Resources

About