Current interpretations and scientific rationale of the ozone usage in dentistry: A systematic review of literature

Abstract

In the era of antibiotic resistance, a naturally occurring substance is needed to completely cure the infection without any toxic side-effects; a responsibility that “O 3 or Ozone” seems to implement sincerely. Ozone gas has a high-oxidation potential and has the capacity to stimulate blood circulation and the immune response. It is a great supplement to conventional therapeutic dental modalities. Treatment may be achieved by increasing the resistance of the tooth against the microbial activity and reducing the extent of microbial activity. In addition to the recent materials and techniques, the therapeutic actions of ozone may provide beneficial results by reducing the demineralization of the tooth. Its bactericide, virucide and fungicide effects are based on its strong oxidation effect with the formation of free radicals as well as its direct destruction of almost all microorganisms. This potentially beneficial agent has been used in dentistry also. Ozone has a wide application in dentistry which includes treatment of carious lesions, root canal disinfection, wound healing impairments after surgical interventions, plaque control, disinfection of dentures, etc., The purpose of this article is to summarize the mechanism of action and different modalities of ozone therapy in the practice of dentistry.

Effect of topical ozone therapy on denture-related traumatic ulcers: A case report

“…After 1840. when Christian F.Schonbein, Father of ozone therapy, had introduced word ozone, it becomes one of the most controversial research topics in medicine [8]. 1896 Nikola Tesla patented the first Ozone generator and by that facilitate the use of this gas.1932 for the first time Edward Fisch used ozone for control of infections in dental practice.…”

“…The aim of treatment is to remove ethiologyical factor, relieve the symptoms and induce the dynamic and complex biological process of closing the wounded area (1). Recent investigations of ozone have reported that ozone can induce the wound healing [5,6,7,8] Ozone is unstable triatomic molecule, consisting of three oxygen atoms (O3) which has been used for almost 150 years in medicine as a therapy for several disease. [5] There are several known actions of ozone on human body, such as anti-microbial, immunostimulating, antihypoxic, analgesic, detoxicating, bioenergetics and biosyn-thetic (activation of the metabolism of carbohydrates, proteins & lipids) [8].…”

Ozone saline solution counteracts bisphosphonates noxious effects in primary human gingival fibroblasts

“…(b) stimulator of the circulatory system, increasing haemoglobin synthesis and the production of red blood cells, thereby producing tissue oxygenation; (c) modulator of immune cells, acting as a cytokine, and increasing their phagocytosis and diapedesis; (d) stimulator of angiogenesis as well as the proliferation of fibroblasts; and (e) pain reduction capacity [15,33].…”

Reactive oxygen species (ROS) generation, impacts on tissue oxidation and dietary management of non-communicable diseases: A review

“…Ozone is a powerful oxidant which has wide application in medicine and dentistry (Kumar et al, 2014), food processing (O"Donnel et al, 2012) and industrial processes (Cook, 1982). In the atmosphere, the ozone layer prevents dangerous UV rays from reaching the earth"s surface (Loscalzo, 2004).…”