Current Insights into Atopic March

Tsuge, Mitsuru; Ikeda, Masanori; Matsumoto, Naomi; Yorifuji, Takashi; Tsukahara, Hirokazu

doi:10.3390/children8111067

Cited by 55 publications

(76 citation statements)

References 118 publications

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“…Loss-of-function mutations in the filaggrin gene do not increase the risk of food or aeroallergen sensitivity independently of AD status [ 68 , 69 ], suggesting there must be other important genetic and/or environmental modifiers such as allergens, environmental pollutants, and oxidative stress that are required for the development of allergic skin inflammation, generalized T2 inflammation, and progression of the atopic march [ 8 , 70 ]. Allergens and irritants via the impaired skin barrier can lead to the release of alarmins (TSLP, IL-25, IL-33) which activate immature DCs and group 2 innate lymphoid cells (ILC2s) [ 70 ]. DCs then process the allergens, present them to naïve T cells, and induce Th2 differentiation.…”

Section: Comorbidities Of Admentioning

confidence: 99%

“…DCs then process the allergens, present them to naïve T cells, and induce Th2 differentiation. [ 70 ] Additionally, ILC2 cells contribute to an antigen-non-specific Th2 skewing [ 70 , 71 , 72 ]. Overall, the extensive activation of the Th2 pathway towards food and environmental allergens due to leaky epithelial barriers may secondarily lead to excessive B cell class switching to IgE, to endo- and exogenous antigens and pathogens [ 73 ].…”

Section: Comorbidities Of Admentioning

confidence: 99%

“…Overall, the extensive activation of the Th2 pathway towards food and environmental allergens due to leaky epithelial barriers may secondarily lead to excessive B cell class switching to IgE, to endo- and exogenous antigens and pathogens [ 73 ]. In addition to T cell skin infiltration causing AD, concurrent redistribution of memory T cells from the skin into the circulation, gut, lung, and nose may thus initiate the atopic march from AD to FA, asthma, and eventually, AR [ 70 , 73 ].…”

Section: Comorbidities Of Admentioning

confidence: 99%

See 2 more Smart Citations

From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine

Maintz

Bieber

Simpson³

et al. 2022

JPM

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: Atopic dermatitis (AD) affects up to 20% of children and is considered the starting point of the atopic march with the development of food allergy, asthma, and allergic rhinitis. The heterogeneous phenotype reflects distinct and/or overlapping pathogenetic mechanisms with varying degrees of epidermal barrier disruption, activation of different T cell subsets and dysbiosis of the skin microbiome. Here, we review current evidence suggesting a systemic impact of the cutaneous inflammation in AD together with a higher risk of asthma and other comorbidities, especially in severe and persistent AD. Thus, early therapy of AD to restore the impaired skin barrier, modified microbiome, and target type 2 inflammation, depending on the (endo)phenotype, in a tailored approach is crucial. We discuss what we can learn from the comorbidities and the implications for preventive and therapeutic interventions from precision dermocosmetics to precision medicine. The stratification of AD patients into biomarker-based endotypes for a precision medicine approach offers opportunities for better long-term control of AD with the potential to reduce the systemic impact of a chronic skin inflammation and even prevent or modify the course, not only of AD, but possibly also the comorbidities, depending on the patient’s age and disease stage.

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Section: Comorbidities Of Admentioning

confidence: 99%

Section: Comorbidities Of Admentioning

confidence: 99%

Section: Comorbidities Of Admentioning

confidence: 99%

See 1 more Smart Citation

From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine

Maintz

Bieber

Simpson³

et al. 2022

JPM

View full text Add to dashboard Cite

show abstract

“…In analogy with the increased prevalence of asthma [4], the incidence in food allergies has increased considerably over the last few decades [5][6][7][8]. This is reflected by the atopic march theory that states that allergic diseases start in infancy with atopic dermatitis and food allergy and later progress to the development of allergic asthma and allergic rhinitis [9]. Allergic diseases are strongly associated with Westernized lifestyle and feeding practices, as prevalence in developing countries is also rising [10].…”

Section: Introductionmentioning

confidence: 99%

Relevance of Early Introduction of Cow’s Milk Proteins for Prevention of Cow’s Milk Allergy

et al. 2022

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Food allergy incidence has increased worldwide over the last 20 years. For prevention of food allergy, current guidelines do not recommend delaying the introduction of allergenic foods. Several groundbreaking studies, such as the Learning Early About Peanut Allergy study, showed that the relatively early introduction of this allergenic food between 4–6 months of age reduces the risk of peanut allergy. However, less is known about the introduction of cow’s milk, as many children already receive cow’s-milk-based formula much earlier in life. This can be regular cow’s milk formula with intact milk proteins or hydrolyzed formulas. Several recent studies have investigated the effects of early introduction of cow’s-milk-based formulas with intact milk proteins on the development of cow’s milk allergy while breastfeeding. These studies suggest that depending on the time of introduction and the duration of administration of cow’s milk, the risk of cow’s milk allergy can be reduced (early introduction) or increased (very early introduction followed by discontinuation). The aim of this narrative review is to summarize these studies and to discuss the impact of early introduction of intact cow’s milk protein - as well as hydrolyzed milk protein formulas - and the development of tolerance versus allergy towards cow’s milk proteins.

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“…Over the past few decades, the incidence of allergic diseases has continued to rise, especially in developing countries [ 1 ]. Many cross-sectional and longitudinal studies have shown that the occurrence of allergic diseases follows a natural process, including the time evolution from preschool atopic dermatitis and food allergy to school-age asthma and allergic rhinitis, as well as the spatial evolution from the skin and gastrointestinal tract to respiratory tract [ 2 , 3 ]. With the consensus of the natural process of allergy, the whole-course management of allergy has been advocated in recent years [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases

Tao

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the potential mechanisms of Yupingfeng Powder (YPFP) in the treatment of allergic diseases by using network pharmacology and molecular docking technology. Methods. The active components and targets of YPFP were screened by the TCMSP database. The targets associated with atopic dermatitis, asthma, allergic rhinitis, and food allergy were obtained from GeneCards and OMIM databases, respectively. The intersection of the above disease-related targets was identified as allergy-related targets. Then, allergy-related targets and YPFP-related targets were crossed to obtain the potential targets of YPFP for allergy treatment. A protein-protein-interaction (PPI) network and a drug-target-disease topology network were constructed to screen hub targets and key ingredients. Next, GO and KEGG pathway enrichment analyses were performed separately on the potential targets and hub targets to identify the biological processes and signaling pathways involved. Finally, molecular docking was conducted to verify the binding affinity between key ingredients and hub targets. Results. In this study, 45 active ingredients were identified from YPFP, and 48 allergy-related targets were predicted by network pharmacology. IL6, TNF, IL1B, PTGS2, CXCL8, JUN, CCL2, IL10, IFNG, and IL4 were screened as hub targets by the PPI network. However, quercetin, kaempferol, wogonin, formononetin, and 7-O-methylisomucronulatol were identified as key ingredients by the drug-target-disease topological network. GO and KEGG pathway enrichment analysis indicated that the therapeutic effect of YPFP on allergy involved multiple biological processes and signaling pathways, including positive regulation of fever generation, positive regulation of neuroinflammatory response, vascular endothelial growth factor production, negative regulation of cytokine production involved in immune response, positive regulation of mononuclear cell migration, type 2 immune response, and negative regulation of lipid storage. Molecular docking verified that all the key ingredients had good binding affinity with hub targets. Conclusion. This study revealed the key ingredients, hub targets, and potential mechanisms of YPFP antiallergy, and these data can provide some theoretical basis for subsequent allergy treatment and drug development.

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Current Insights into Atopic March

Cited by 55 publications

References 118 publications

From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine

From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine

Relevance of Early Introduction of Cow’s Milk Proteins for Prevention of Cow’s Milk Allergy

Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases

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