Current insights in renal cell cancer pathology

Renal Cell Carcinoma: A Study through NMR-Based Metabolomics Combined with Transcriptomics

“…The prognosis is also variable; metastatic or recurrent RCC usually indicate poor prognosis with rare long-term survival [2,3,4]. Thus, there is a huge interest in identifying RCC specific biomarkers, early and easily detectable or able to assess the response to the therapy strategies [5].…”

Epigenetic silencing of Na,K-ATPase β1subunit geneATP1B1by methylation in clear cell renal cell carcinoma

“…Approximately 75% of the RCC cases are classified as clear cell RCC (ccRCC). 2 The most common genetic event in the evolution of sporadic ccRCC is inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene (TSG). [3][4][5][6] VHL inactivation leads to stabilization of the hypoxia-inducible transcription factor (HIF) and activation of a wide repertoire of hypoxia response genes.…”

Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma

“…1 The most common form of kidney cancer in adults is renal cell carcinoma (RCC) of which the majority (>75%) is classified as clear cell (conventional). 2 Though familial RCC accounts for only about 3% of all cases, the investigation of rare familial cases of kidney cancer has provided important insights into the pathogenesis of sporadic RCC. In particular, the finding that germline mutation of the VHL gene caused a syndromic form of inherited RCC and that somatic inactivation of VHL occurred in most sporadic clear cell RCC.…”