Current insight into the role of voltage-gated potassiumion channel 7 (Kv7) channels: an emerging therapy target against epilepsy

Abstract

Kv channels, the voltage-gated potassium channels, are encoded by KCN gene family. Kv channels are important in maintaining the resting membrane potential and spiking threshold, deciding the firing frequency and nerve hyperexcitability, and inducing after hyperpolarization after burst firing. In this family, Kv7 is a special one for it is activated at subthreshold potentials. Because of its specific characteristics, Kv7 channels show pronounced control over the excitability of neurons and often inhibit neuronal excitability. Moreover, it is also documented that mutations of Kv7 channels are associated with the occurrence of epilepsy, deafness and cardiac arrhythmia. In this review, we discussed the characteristics and functions of Kv channels especially the Kv7 channels, which determined their targeting role in treatment against epilepsy.

Analysis of KATP Channels Opening Probability of Hippocampus Cells Treated with Kainic Acid

“…However, K ATP channels have been placed under the K ir super family of K + channels as it conducts weak inward rectifier potassium current ( 19 , 20 ). K + channels are the most dominant ion conductive pathways in electrically excitable cells and regulate neuronal excitability by controlling the firing frequency of the action potentials ( 20 , 21 ). The opening of the K + channels hyperpolarise the cell by causing an efflux of K + ions.…”