Current indications and future perspective of fluorescence bronchoscopy: A review study

Moghissi, K.; Dixon, Kate; Stringer, Maurice

doi:10.1016/j.pdpdt.2009.01.008

Cited by 30 publications

(32 citation statements)

References 65 publications

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“…Furthermore, changes in PS activity could be used as a means of determining treatment success or failure, which will be discussed later [62]. The fluorescence capability of most PSs is under-utilized and could be employed to assist in improving treatment targeting or even delineation of margin status for surgery [63]. It should be noted that PDT and fluorescence are competing pathways, so highly efficient fluorescing agents may be poor PSs and vice versa.…”

Section: Imagingmentioning

confidence: 99%

Future of Oncologic Photodynamic Therapy

Bagnato²,

2010

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Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clinical trials have demonstrated the efficacy of PDT on various cutaneous and deep tissue tumors. However, current photosensitizers and light sources still have a number of limitations. Future PDT will build on those findings to allow development and refinement of more optimal therapeutic agents and illumination devices. This article reviews the current state of the art and limitations of PDT, and highlight the progress being made towards the future of oncologic PDT.

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Section: Imagingmentioning

confidence: 99%

Future of Oncologic Photodynamic Therapy

Bagnato²,

2010

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“…Generally, normal esophageal mucosa appeared bright green on AFI endoscopy because of autofluorescence from collagen in the submucosa that penetrates the mucosa. In patients with early stage cancer, however, the color pattern often shifted from green to red or purple because of the decreased intensity of autofluorescence . Our study found that many GERD patients also exhibited this purple color change.…”

Section: Discussionmentioning

confidence: 47%

Autofluorescence imaging endoscopy for predicting acid reflux in patients with gastroesophageal reflux disease

Wang

Uedo

Yang

et al. 2014

J of Gastro and Hepatol

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Background and Aim Endoscopic diagnosis of gastroesophageal reflux disease (GERD) remains challenging. Autofluorescence imaging (AFI) can identify indistinct mucosal lesions; however, its ability to diagnose GERD has not been determined. This study aimed to compare the diagnostic capabilities of standard white light imaging (WLI) and AFI using pH/impedance testing as gold standard. Methods In this prospective observational trial, 95 consecutive patients with classic reflux symptoms were screened in two tertiary care referral hospitals and 82 were included. GerdQ questionnaire was administered to each patient. Endoscopy with WLI and AFI, and ambulatory 24‐h pH/impedance monitoring were performed. Erosive esophagitis on WLI was defined as positive for GERD, whereas on AFI endoscopy, the appearance of one or more longitudinal purple lines > 1 cm was defined as indicative of GERD. We assessed the diagnostic capacities of each method, as well as inter‐observer agreement on AFI findings. We also looked at factors associated with having a positive AFI finding. Results The sensitivity and accuracy of AFI (77% and 67%, respectively) in detecting GERD were higher than those of WLI (21% and 52%, respectively), although the specificity of AFI (53%) was lower than that of WLI (97%); McNemar test showed a significant difference (P = 0.000). Inter‐observer reliability analysis of AFI findings indicated substantial agreement (Kappa = 0.630, P = 0.000). Multivariate analysis showed that abnormal AFI findings significantly correlated with positive pH/impedance result (odds ratio = 0.242, 95% confidence interval = 0.087–0.673, P = 0.007). Conclusions AFI can reveal GERD‐related mucosal changes, invisible on conventional WLI, thus improve the endoscopic diagnosis of GERD.

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“…Une étude clinique réalisée sur 46 patientes a conforté l'intérêt de la spectroscopie Raman pour la détection des dysplasies du col de l'utérus [23]. Lieber Ophtalmologie [32] Dermatologie [24] Urologie [13] Gastroentérologie [17] Gynécologie [23] Dermatologie [18] Pneumologie [25] Otorhinolaryngologie (ORL) [30] Gastroentérologie [14] Pneumologie (fluorescence + autofluorescence) [37] Dermatologie [33] Ophtalmologie [9] ORL [20] liées à la transformation maligne. Cette instrumentation a montré une bonne capacité à distinguer in situ des zones malignes, voire pré-malignes dans la vessie [27], le col de l'utérus [28] et la cavité buccale [34].…”

Section: Spectroscopie Ramanunclassified

Quelles perspectives pour l’imagerie photonique in vivo en pratique clinique ?

Laplace‐Builhé

Abbaci

2010

Oncologie

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With the increasing molecular understanding of disease processes, there has been a dramatic change, over the past years, in our consideration of non invasive imaging of cancer in humans. The miniaturization of optical devices, and fiber optic coupling greatly improved the ability of in-vivo photon imaging to emphasis pathological pathways at molecular level or to achieve true "optical biopsy". Innovative fluorescent imaging agents called "smart probes" can provide in-vivo readouts of some of the key activities known to underlie human disease states in oncology. The current contribution of biophotonics in clinical imaging remains limited but diffuse optical tomography of the breast has paved the way. New optical concepts come to age and should soon find their place among the other imaging modalities.

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Current indications and future perspective of fluorescence bronchoscopy: A review study

Cited by 30 publications

References 65 publications

Future of Oncologic Photodynamic Therapy

Future of Oncologic Photodynamic Therapy

Autofluorescence imaging endoscopy for predicting acid reflux in patients with gastroesophageal reflux disease

Quelles perspectives pour l’imagerie photonique in vivo en pratique clinique ?

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