“…In Italy, although eight regions have recently introduced varicella vaccination in their childhood immunization program, chickenpox continues to have an endemo-epidemic trend (Alfonsi et al, 2011). Nevertheless, our data showed that in regions that first introduced a universal immunization programme, coverage rates increased rapidly, with a subsequent decreasing trend in varicellarelated hospitalizations and statutory notifications.…”
Section: Discussionmentioning
confidence: 59%
“…Concerning vaccinations, both mandatory (diphtheria, tetanus, poliomyelitis and hepatitis B) and non-mandatory vaccinations (pertussis, Haemophilus influenzae type b, measles, mumps and rubella) are included in the essential health care interventions, and must by law be provided to all children free of charge across Italy (Alfonsi et al, 2011). Until the approval of the last PNPV in 2012, varicella vaccination was not included amongst immunizations to be offered free of charge to all children, and the regions adopted different varicella vaccination policies.…”
“…In Italy, although eight regions have recently introduced varicella vaccination in their childhood immunization program, chickenpox continues to have an endemo-epidemic trend (Alfonsi et al, 2011). Nevertheless, our data showed that in regions that first introduced a universal immunization programme, coverage rates increased rapidly, with a subsequent decreasing trend in varicellarelated hospitalizations and statutory notifications.…”
Section: Discussionmentioning
confidence: 59%
“…Concerning vaccinations, both mandatory (diphtheria, tetanus, poliomyelitis and hepatitis B) and non-mandatory vaccinations (pertussis, Haemophilus influenzae type b, measles, mumps and rubella) are included in the essential health care interventions, and must by law be provided to all children free of charge across Italy (Alfonsi et al, 2011). Until the approval of the last PNPV in 2012, varicella vaccination was not included amongst immunizations to be offered free of charge to all children, and the regions adopted different varicella vaccination policies.…”
“…A great heterogeneity among regions about health matters has emerged in Italy, sometimes with differences even within the same region [17]. An optimal situation is present only in four regions (with a population equal to 18% of the total Italian population), where individual data on vaccination history collected at LHUs is shared in real time with the regional level.…”
“…However, it was in the following years increasingly offered also to other target groups, dependent on the vaccination policies in the individual regions [2]. Since 2008, pneumococcal vaccination has been included in the NIP free of charge for all newborns; it was administered as a three-dose schedule (during the first year of life) concomitantly with the hexavalent vaccine against diphtheria (D), tetanus (T), acellular pertussis (aP), Haemophilus influenzae type b (Hib), hepatitis B virus (HBV) and inactivated poliovirus (IPV) [4,5]. Thus, in routine practice, PCV and the hexavalent vaccine were usually administered concomitantly to children in a single vaccination session.…”
This study was aimed at estimating the risk of all types of adverse events following immunisation (AEFI), neurological events and convulsions following the co-administration of 13-valent pneumococcal polysaccharide conjugate vaccine (PCV13) with hexavalent vaccine. Paediatric spontaneous reports and exposure to vaccinations in four Italian regions were available. The estimated incidence rate ratio (IRR) for AEFI following co-administration of hexavalent vaccine with either PCV13 or PCV7 was 1.08 (95% confidence interval (CI): 0.91-1.28); the IRR for, respectively, neurological events and convulsion following co-administration of PCV13 with hexavalent vaccine were 1.27 (95% CI: 0.85-1.89) and 1.43 (95% CI: 0.70-2.91). Co-administration of PCV13 with hexavalent vaccine had a protective effect against AEFI (IRR = 0.59; 95% CI: 0.49-0.72). This protective effect was not observed for neurological events or convulsions following coadministration of PCV13 with hexavalent vaccine compared with single administration (IRR = 1.44; 95% CI: 0.77-2.67 and IRR = 1.46; 95% CI: 0.50-4.25, respectively). We observed a trend of increased risk of neurological events or convulsions following PCV13 used in routine practice. Analysis of spontaneously reported data is a quick method to estimate associations between vaccines and less common adverse events. Given methodological limitations these findings cannot be conclusive and require further investigations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.